Opening NFL Week 10 Odds – Spread, Total, Moneyline for ALL 14 Games

• The NFL Week 10 odds have been posted
• Both in the hunt for the NFC’s #1 seed, the Eagles and Packers meet on Monday Night Football
• See the opening NFL Week 10 odds, including the point spread, moneyline, and O/U for every game

The NFL Week 10 schedule sees four teams on bye – Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, Tennessee Titans – leaving 14 games on the slate. Week 10 starts with a TNF mismatch between the Las Vegas Raiders (2-5) and Denver Broncos () before the International Series resumes early Sunday morning with the Atlanta Falcons (3-5) and Indianapolis Colts (6-2) meeting in Berlin.

The week wraps with a high-stakes game between the Philadelphia Eagles (6-2) and Green Bay Packers (5-2-1) at Lambeau on Monday.

The table below lists the opening NFL Week 10 odds – moneyline, point spread, and total – for all 14 games.

NFL Week 10 Odds

The biggest spread of the week so far is in Bills/Dolphins, where Buffalo is a 9.5-point road favorite against the reeling Phins. The highest total on the board in the opening Week 10 odds is 50.5 O/U in Lions vs Commanders, while the lowest total is just 37.5 in Browns vs Jets.

BETMGM SPORTSBOOK

Offer

T&Cs

Get Up To $1,500 Paid Back in Bonus Bets

Gambling problem? Call 1-800-GAMBLER (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

LOCK IN PROMO

CODE: SBD1500

CODE: SBD1500

SIGNUP BONUS

GET $1,500
BACK

BET NOW

Odds as of November 2nd at BetMGM, bet365, DraftKings, and FanDuel. Bookmark SBD’s FanDuel Missouri page to see the latest promo and sign-up bonus offers ahead of launch in December.

Opening Falcons vs Colts Odds

The Indianapolis Colts (6-2) couldn’t consolidate their status as the top team in the NFL on Sunday, falling 27-20 at Pittsburgh as 3.5-point road favorites. They now sit tied for first in the AFC with the New England Pariots.

But that hasn’t soured oddsmakers on Indy’s overall potential, and the Colts will head to Berlin as touchdown-favorites over the Atlanta Falcons (3-5), who lost a 24-23 heartbreaker at New England with a late missed XP proving the difference.

Opening Eagles vs Packers Odds

The Green Bay Packers (5-2-1) and Philadelphia Eagles (6-2) will meet in a rematch of last year’s NFC Wild Card round in Week 10, but this time Lambeau Field will play host. The Eagles won 22-10 at home in January. Green Bay is a 2.5-point favorite to return the favor at home in the Week 10 NFL odds.

The total has opened at just 43.5 points, indicating that oddsmakers expect the two stout defenses to control the game, while Philly’s run-heavy approach of offense churns clock.

Opening Rams vs 49ers Odds

The Los Angeles Rams (6-2) and San Francisco 49ers (6-3) meet in a massive NFC West game in Week 10. If the 5-2 Seahawks lose one of their next two games, then this Rams/Niners clash will be for first place in the stacked division.

The healthier Rams have opened as 2.5-point road favorites, despite the 49ers already earning a 26-23 road win at Los Angeles earlier in the season. The Rams enter Week 10 as the top NFC team in the Super Bowl odds, thanks to Detroit’s shocking 27-24 upset loss at home to JJ McCarthy and the Minnesota Vikings.