Opening NFL Week 12 Odds – Spread, Total, Moneyline for All 13 Games

• The NFL Week 12 odds have been posted
• Week 12 is highlighted by the Ravens vs Chargers on MNF
• Below, see the opening NFL Week 12 odds for all 13 games on the schedule

With two games remaining in Week 11, the opening Week 12 NFL odds have been posted. The Week 12 schedule starts with an AFC North battle between the division-leading Pittsburgh Steelers (8-2) visiting the division-losing Cleveland Browns (2-8) on Thursday Night Football. It culminates with the Baltimore Ravens (7-4) vs LA Chargers (6-3) on MNF with the other 11 games on Sunday. The table below lists the opening odds for all Week 12 games.

Opening NFL Week 12 Odds

The Falcons, Bills, Bengals, Saints, Jets, and Jaguars are on bye in Week 12.

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The latest Super Bowl odds continue no longer favor the two-time reigning champion Chiefs. As of Week 11, the Detroit Lions (+400) had inched past KC (+450) at the top of the board.

Biggest Week 12 Spread: Chiefs (-10.5) vs Panthers

The biggest spread in Week 12 is in the perceived mismatch between the Kansas City Chiefs (9-0) and Carolina Panthers (3-7), where the visiting Chiefs are 10.5-point road favorites.

Kansas City appeared headed towards its first L of the season, trailing Buffalo 23-14 in the fourth quarter in Week 11 afternoon action, while the Panthers have won two in a row and are coming off a bye after their Week 9 win over the Giants in London.

The second-biggest spread is in the NFC East battle between the Washington Commanders (7-4) and injury-riddled Dallas Cowboys (3-6), who have lost four in a row. Washington has been listed as a 9.5-point home favorite

Making matters worse for Cooper Rush and the Cowboys, they will also be on a short week after facing Houston on Monday Night Football on Nov. 18.

Highest Week 12 Total: Lions vs Colts (49.5 O/U)

The highest game total in Week 12 is 49.5 in the Detroit Lions (9-1) vs Indianapolis Colts (5-6) matchup. Detroit’s offense continued to cruise in Week 11, putting up its second fifty-burger of the season in a 52-6 rout of the Jacksonville Jaguars.

With Anthony Richardson back under center in place of Joe Flacco, the Colts’ offense had its best game in weeks in Week 11, earning a 28-27 comeback win against the Jets. Richardson was 20-0f-30 for 272 yards, one TD, and no interceptions. His passer rating of 106.5 was his second-highest of his career.

Lowest Week 12 Total: Steelers vs Browns (40.0 O/U)

The lowest total of the week is in the first game on TNF; Steelers vs Browns has opened with a total of just 40.0. The Steelers only had one game go over 40 points in the first five weeks but followed that up with a run of four straight that hit 45 or higher.

Cleveland’s offense has been on fumes the last two weeks (27-10 loss vs LAC, 35-14 loss at NO). While the defense still has a ton of talent, it’s been getting no respite thanks to the offense’s repeated three-and-outs.