Opening NFL Week 2 Odds – Spread, Total & Moneyline for All 16 Games

• The NFL Week 2 odds have been posted, including Eagles vs Chiefs
• The Eagles have opened as road favorites against KC in a Super Bowl 58 and 59 rematch
• See the NFL Week 2 odds for every game, including the spread, moneyline, and game total

Just two games remain in the first week of the NFL season and odds have already been posted for NFL Week 2. The table below lists the opening odds for all 16 games, including the opening point spread, moneyline, and game total.

Week 2 will start with Commanders vs Packers on TNF and culminate with a Monday night double-header: Buccaneers vs Texans followed by Chargers vs Raiders. The marquee matchup of the week is undoubtedly the Super Bowl rematch between the reigning-champion Eagles and runner-up Chiefs, which will be America’s Game of the Week at 4:25 pm ET on FOX.

NFL Week 2 Odds

The biggest spread on the board, by a wide margin, is in the Browns/Ravens matchup in Baltimore, where the Ravens are 12.5-point home chalk.

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Bookmark SBD’s NFL public betting page to see where the money is going and how the lines move over the course of the week.

Eagles vs Chiefs Odds: Philadelphia Favored on the Road

The Super Bowl runner-up Chiefs will be out for a modicum of vengeance in Week 2 when they host the team that embarrassed them (40-22) at the Superdome last February.

After dropping their Week 1 game to the Chargers in Brazil, this Week 2 matchup will have a must-win feel to it for the Chiefs. Teams that start the season 0-2 go onto make the postseason just over 10% of the time. Kansas City was a field-goal favorite against LAC in Week 1.

Despite going 15-2 in the regular season last year and winning the AFC, the Chiefs finished the 2024-25 season just 9-11 against the spread.

The Eagles took a hard-fought 24-20 home victory over NFC East-rival Dallas in Week 1, failing to cover as 8.5-point favorites.

Highest NFL Week 2 Total: Jaguars vs Bengals

The highest total on the board in the Week 2 NFL odds is 50.5 in Jacksonville vs Cincinnati.

In Week 1, bettors moved the O/U in Browns vs Bengals from an opening line of 44.5 all the way to 47.5. But the teams combined for just 33 points in a 17-16 Cincinnati victory.

The Jaguars/Panthers matchup was only slightly higher scoring; Travis Etienne propelled the Jags to a 26-10 home victory with 143 rushing yards on just 16 carries (8.9 YPC). The final score was 8.5 points shy of the closing O/U of 44.5.

The Bengals and Jaguars’ Week 1 games were both part of a strong under trend in Week 1. At the time of writing, Week 1 games were on track to go 2-12 O/U prior to the SNF matchup between the Ravens/Bills.

Lowest NFL Week 2 Total: Seahawks vs Steelers

The Seahawks/Steelers game in Pittsburgh has opened with a total of just 40.5, two points lower than any other game.

Aaron Rodgers and the Steelers also had the lowest game-total of Week 1; their game against the Jets closed at just 38.0 (after opening at 42.5). They made under bettors look foolish in a 34-32 shootout victory over Justin Fields and company.

The 41-year-old Rodgers turned back the clock with a four-touchdown performance and near-perfect 136.7 passer rating.

The Seahawks, on the other hand, showed out defensively in a defensive slugfest against the division-rival 49ers. Seattle was leading 13-10 with under two minutes to go in the fourth quarter.

New Seattle QB Sam Darnold, who had a career year with the Vikings last season, was just 14-of-20 for a paltry 99 yards.