Opening NFL Week 3 Odds – Spread, Total, Moneyline for All 16 Games

• The NFL Week 3 odds have been posted at online sportsbooks
• Only one Week 3 game total has opened above 50 points
• See the opening NFL Week 3 odds including point spreads, totals, and moneylines

NFL Week 3 will start with an AFC East mismatch between the undefeated Buffalo Bills and winless Miami Dolphins on Thursday Night Football, and culminate with a heavyweight tilt between the Detroit Lions and Baltimore Ravens on MNF.

The NFL Week 3 odds are already out. The table below lists the opening Week 3 odds (spread, total, and moneyline) for all 16 games on the slate.

Opening NFL Week 3 Odds

Bookmark SBD’s NFL odds page to see up-to-the-minute lines throughout the week.

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Biggest Spread in NFL Week 3 Odds

The biggest spread on the board by a wide margin comes from Dolphins/Bills, where Buffalo (2-0 SU, 2-0 ATS) is laying nearly 12.5 points at home against the winless Dolphins, who are also 0-2 against the spread.

Buffalo owns a 41-40 win over Baltimore as 1.5-point home underdogs, and a 40-10- rout of the Jets as 6.5-point road favorites. Miami was embarrassed 33-8 by Indianapolis in Week 1 as one-point road underdogs, and fell 33-27 to the Patriots in Week 2 as 2.5-point home favorites.

Both teams are 1-1 O/U.

Buffalo beat Miami twice last year, 31-10 on the road and 30-27 at home. Those two wins extended the Bills’ overall win streak against Miami to six games.

Highest Total in NFL Week 3 Odds

Only one total from Week 3 is over the 50-point plateau, and that’s from the opening MNF odds between the Detroit Lions (1-1 SU, 1-1 ATS, 1-1 O/U) and Ravens (1-1, 1-1 ATS, 2-0 O/U). The total has opened at 51.5 with -110 odds each way.

Baltimore is averaging an NFL-high 40.5 PPG through two weeks, and Baltimore games are averaging an NFL-high 69.5 PPG. Lamar Jackson and company suffered a heartbreaking 41-40 loss to the Bills in Week 1, blowing a 15-point lead in the final four minutes. They rebounded in Week 2, routing the Browns 41-17 as 12.5-point home chalk.

The Lions offense rebounded from a disappointing 26-13 Week 1 loss at Green Bay with a sensational 52-21 victory over the Bears, covering and then some as 6.5-point home favorites.