Opening NFL Week 4 Odds – Spread, Moneyline & Total for All 16 Games

• The opening NFL Week 4 odds have been posted
• The Vikings and Steelers play the first International Series game in Dublin on Sunday morning
• See the opening NFL Week 4 odds, including spread, total, and moneyline for all 16 games

A wild Sunday is almost in the books and the NFL Week 4 odds have been posted. The NFL Week 4 schedule starts with Seahawks vs Cardinals on TNF, continues with a Vikings/Steelers clash in Dublin early on Sunday, and culminates with another Monday Night Football doubleheader: Jets vs Dolphins, plus Bengals vs Broncos.

The table below lists the opening NFL Week 4 odds for all 16 games, including the Week 4 point spreads, totals, and moneylines.

Opening NFL Week 4 Odds

The biggest spread on the board, for the second straight week, is in the Bills game. Buffalo is laying 14.5 points at home against the hapless Saints, who are 0-2 and currently getting whitewashed by the Seahawks (41-6 late in the third quarter). The highest total on the board so far is 48.5, an honor shared by three games: Titans vs Texans, Ravens vs Chiefs, and Packers vs Cowboys. The lowest total comes from Vikings vs Steelers in Ireland, where the number has opened at just 40.5 points.

NFL odds as of 6:13 pm ET at ESPN Bet, FanDuel, and DraftKings.

Opening Ravens vs Chiefs Odds

Neither the Kansas City Chiefs (0-2) nor Baltimore Ravens (1-1) has played in Week 3 yet, but oddsmakers have still felt comfortable opening the line on their massive Week 4 meeting at Arrowhead.

After losing at home to the Eagles (20-17) in Week 2 as one-point underdogs, the Chiefs have opened as three-point underdogs to Lamar Jackson and company, marking the first time in Mahomes’ career that the Chiefs have been home underdogs in back-to-back games.

Indeed, it’s only the third time ever that Mahomes has been a home underdog.

The Chiefs were also home underdogs to the Bills in Week 6 of the 2022 season, a game Buffalo won 24-20, meaning Mahomes is 0-2 as a home underdog to date.

Opening Vikings vs Steelers Odds in Dublin

The NFL International Series starts in Week 4 with the Minnesota Vikings (2-1) facing the Pittsburgh Steelers (2-1) in Dublin, Ireland. The opening Vikings vs Steelers odds favor Pittsburgh by a point-and-a-half over a Minnesota team that will continue to start Carson Wentz at QB due to an injury to JJ McCarthy.

Both teams are coming off of impressive defensive performances in Week 2.

Facing backup Jake Browning and the Bengals, the Viking D scored two touchdowns (both from cornerback Isaiah Rodgers) and generated five turnovers during a 48-10 rout in Minneapolis. Andrew Van Ginkel had two of Minnesota’s three sacks.

Starting in place of McCarthy, veteran Carson Wentz was solid as a game-managers, going 14-of-20 (70%) for 173 yards, two touchdowns, and – crucially – no turnovers.

The Steelers gutted out a 21-14 road win at New England, despite getting outgained 369-203. Aaron Rodgers threw for just 139 yards on 23 attempts with two touchdowns and one interception.

Like Minnesota, the Pittsburgh defense had a day for the ages, generated five takeaways of their own (one interception, four fumble recoveries), to go along with five sacks of New England’s Drake Maye. TJ Watt, who has already faded badly in the NFL Defensive Player of the Year odds, finally had a game worthy of his preseason hype, generating two five sacks and one forced-fumble (plus the recovery).

Opening Eagles vs Buccaneers Odds in Battle of Unbeatens

Even at this early stage of the season, only one Week 3 game will feature two unbeaten teams: the reigning Super Bowl-champion Philadelphia Eagles (3-0, 1-2 ATS) visiting the NFC South-leading Tampa Bay Buccaneers (3-0, 2-1 ATS). The Eagles have opened as three-point road favorites.

Philadelphia authored a stunning 33-26 comeback against the Rams in Week 2, scoring the last 26 points of the game to overcome a 26-7 second-half deficit. Jordan Davis blocked a would-be game-winning field-goal attempt on the final play, returning it for a TD as time expired.

The Buccaneers were almost on the wrong end of the most-embarrassing loss of Week 3, allowing the winless Jets to claw back from 23-6 down in the fourth quarter to take a 27-26 lead with under two minutes to play.

But Baker Mayfield led the Bucs on a 48-yard drive, setting Chase McLaughlin up for the game-winning 36-yard chip shot as time expired.

Bookmark SBD’s NFL public betting splits to see where the money is going for every Week 4 game.

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