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NFL Picks Against the Spread for Week 15: Bet on Shedeur Sanders vs Chicago

Zach Reger

By Zach Reger in NFL News

Published:


Shedeur Sanders celebrating after scoring a touchdown
Dec 7, 2025; Cleveland, Ohio, USA; Cleveland Browns quarterback Shedeur Sanders (12) celebrates after scoring a touchdown against the Tennessee Titans during the fourth quarter at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images
  • It is now NFL Week 15
  • In my NFL ATS picks this week, I am targeting one underdog and two favorites
  • Keep reading for all my NFL picks against the spread for Week 15, plus my best bet analysis

We have made it to NFL Week 15, and there are plenty of intriguing matchups for teams trying to claim their spot in the NFL playoff bracket.

I am 7-4-1 (63.6%) with my best bets against the spread since Week 11.

See below for my NFL Week 15 against the spread picks for Sunday, December 14, plus my analysis for my best bets.

NFL Week 15 Picks Against the Spread

MatchupSpreadPick
Ravens vs BengalsBAL -2.5Ravens -2.5
Bills vs PatriotsBUF -1Bills -1
Commanders vs GiantsNYG -2.5Giants -2.57
Browns vs BearsCHI -7.5Browns +7.5
Chargers vs ChiefsKC -5.5Chiefs -5.5
Raiders vs EaglesPHI -12Eagles -12
Jets vs JaguarsJAX -13.5Jaguars -13.5
Cardinals vs TexansHOU -9.5Cardinals +9.5
Packers vs BroncosGB -2.5Broncos +2.5
Lions vs RamsLAR -6Lions +6
Panthers vs SaintsCAR -2.5Panthers -2.5
Titans vs 49ersSF -12.5Titans +12.5
Colts vs SeahawksSEA -14Colts +14
Vikings vs CowboysDAL -5.5Vikings +5.5
Dolphins vs SteelersPIT -3Dolpihns +3

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NFL ATS Pick #1: Browns +7.5 vs Bears

While I am betting on the Browns on Sunday, this is more of a pick against the Bears in Week 15. They just lost in heartbreaking fashion to the Packers, but they get to face their rival again in Week 16. This is a weird spot for Chicago playing an AFC team in between two games vs the Packers. I am expecting Chicago to both overlook this game and not exhaust too much energy vs Cleveland.

The Browns offense has improved with Shedeur Sanders under center. They are not lighting anyone on fire, but the Bears secondary has had some issues, and Sanders can do enough to keep Cleveland in this game.

Sports Betting Dime โ€ข

Pick
Odds
AwayPointSpread +7.5
Spread
NFL โ€ข Cleveland Browns @ Chicago Bears
-110 on DraftKings
SCHEDULED โ€ข 12/14/2025
Tally (Win %)
0-0-0 (0%)
Money Meter
$0.00
ROI
0.0%
Betslip #1765570600039-eede-198

This game also has the potential to be extremely cold, which does not bode well for a lot of scoring. The ground games for both teams will be active, and even though the Browns were gashed in the run game last week, I like their unit against the run more than the Bears.

I see this as a close, low-scoring game, so I love getting over a touchdown with the Browns on Sunday.

NFL Week 15 Pick: Bears +7.5 (-110)

NFL ATS Pick #2: Chiefs -5.5 vs Chargers

Kansas City’s season hangs in the balance after dropping back-to-back losses, falling to 6-7. A win vs the Chargers at home on Sunday will do a lot to keep their playoff chances alive.

The Chiefs have not looked like their old selves, but I like them in this spot.

The Chargers are coming off an emotional, hard-fought overtime win over the Eagles on Monday Night Football. They now travel to Kansas City in the cold on a short week. It also does not help that this game is in the early window on Sunday.

Sports Betting Dime โ€ข

Pick
Odds
HomePointSpread -5.5
Spread
NFL โ€ข Los Angeles Chargers @ Kansas City Chiefs
-110 on FanDuel
SCHEDULED โ€ข 12/14/2025
Tally (Win %)
0-0-0 (0%)
Money Meter
$0.00
ROI
0.0%
Betslip #1765570611044-eede-641

Los Angeles is a popular bet this week, but the odds have moved in Kansas City’s direction. The line has shifted from Chiefs -5 to Chiefs -5.5, indicating some sharp money.

The Chargers are 0-4 against the spread in their last four road games, and I believe the Chiefs will take care of business in Week 15 against a familiar foe.

  • NFL Week 15 Pick: Chiefs -5.5 (-110)

NFL ATS Pick #3: Eagles -11.5 vs Raiders

The Raiders are 1-3 against the spread over their last four games, and they would be 0-5 if not for a last-second field goal to barely cover the spread last week. I am looking to bet against the Raiders every week.

Jalen Hurts just played the worst game of his career, but now he is in the perfect spot to bounce back against Las Vegas.

Sports Betting Dime โ€ข

Pick
Odds
HomePointSpread -11.5
Spread
NFL โ€ข Las Vegas Raiders @ Philadelphia Eagles
-115 on Bet365
SCHEDULED โ€ข 12/14/2025
Tally (Win %)
0-0-0 (0%)
Money Meter
$0.00
ROI
0.0%
Betslip #1765570646843-eede-870

Las Vegas has been abysmal this season, and now they have Kenny Pickett starting at quarterback.

I do not mind laying the large spread because I do not know how the Raiders move the ball against this Philly defense. Conversely, the Eagles should have no problem moving up and down the field against Vegas’s secondary.

NFL Week 15 Pick: Eagles -11.5 (-115)

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Zach Reger
Zach Reger

Social Media Manager; Sports Betting Personality & Handicapper

Zach has been involved in the sports betting industry for three years. After starting to bet on sports in college, Zach was interested in how it can make any game interesting. The trends, line movement, and finding unique angles to predict the outcomes of games captivated Zach to get more involved.

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