Seattle Seahawks vs Arizona Cardinals Picks, Props to Target & Betting Odds (TNF)

• Seattle looks to extend its seven-game win streak against Arizona on Thursday, Sep. 25
• The Thursday Night Football odds have shifted dramatically, with the Cardinals going from favorites to home underdogs
• See the Seahawks vs Cardinals picks, predictions, player props to bet, and latest betting odds

The stacked NFC West takes center stage on Thursday Night Football as the Arizona Cardinals (2-1, 1-0 home, 2-1 ATS, 1-2 O/U) host the Seattle Seahawks (2-1, 1-0 away, 2-1 ATS, 2-1 O/U) at 6:15 pm MT/8:15 pm ET. The entire division is over .500 after three weeks including 3-0 San Francisco; falling to 2-2 would be a big blow to either team’s hopes of winning the NFC West, even at this early stage of the season.

The opening NFL Week 4 odds listed the Cardinals as 1.5-point home favorites, but with injuries mounting on the Arizona sideline, the line has crossed zero and the Seahawks are now slight favorites.

Below, I have set out my favorite Seahawks vs Cardinals picks and predictions, followed by a list of the main Seahawks/Cardinals player props and, lastly, the latest Thursday Night Football odds.

Jump to: SEA vs ARI Picks | SEA vs ARI Player Props | SEA vs ARI Odds

Seattle Seahawks vs Arizona Cardinals Picks & Predictions

• Seattle Seahawks moneyline (-115) at BetMGM
• Under 43.5 (-110) at bet365
• Sam Darnold Over 216.5 Passing Yards (-115) at BetMGM

Everything in this matchup points toward the Seahawks. Their historical dominance is impossible to ignore, having won seven straight games against the Arizona Cardinals while covering the spread in six of those contests. This isn’t just a historical trend; it’s backed by significant current-day advantages.

The single biggest mismatch is Seattle’s high-flying passing offense against a Cardinal secondary that’s missing key starters (Starling Thomas V, Garrett Williams). Quarterback Sam Darnold has been efficient with limited mistakes, completing 70.1% of his passes for 657 yards and a 4-to-2 touchdown-to-interception ratio, continuing the success he found with Minnesota last year, a career-best season for the 28-year-old (4,319 yards, 35 TDs, 12 INTs, 102.5 passer rating).

He’ll face a Cardinals squad reeling from a gut-wrenching 16-15 last-second loss to the San Francisco 49ers. Arizona quarterback Kyler Murray (67.4% completion, 542 yards, 4 TDs, 1 INT) has been solid, but the offense has struggled to find consistency and finish drives. The Arizona offense suffered a big blow earlier this week when RB1 James Conner was placed on IR. Trey Benson, a 2024 third-round pick who had just 291 rushing yards in his rookie season, will now have to carry the water for the Cardinal ground game.

While Arizona has a solid run defense, Seattle’s offense is balanced enough to win through the air. The Cardinals have also struggled mightily against teams with winning records, losing their last four such games outright. Conversely, the Seahawks have been road warriors, winning and covering in their last five games as road underdogs. Trust the trends, the matchups, and the market sentiment.

SEA Seahawks vs ARI Cardinals Player Props

NFL player props as of September 23 at DraftKings, except Walker III’s rushing yards O/U (FanDuel).

Darnold’s passing yards prop, which is 220.5 at DraftKings but as low as 216.5 at , looks particularly appealing. He is averaging 219 yards per game this season and now faces a Cardinals secondary that is the most injured unit he’s seen.

Kyler Murray’s line of 213.5 is set against his 180.7 yards-per-game average, reflecting the expectation that Arizona may need to throw to keep pace.

Trey McBride’s reception prop of 6.5 is a focal point. As Arizona’s most reliable pass-catcher, he should see a heavy target share, especially if the offense is playing from behind.

For Seattle, Jaxon Smith-Njigba’s receiving line of 80.5 is high but reflects his explosive potential against a vulnerable defense.

Seattle Seahawks vs Arizona Cardinals Odds

Odds as of September 23, 2025 from DraftKings.

As of 10:25 am ET on Wednesday, the Cardinal moneyline was as long as +102 (DraftKings), while the best number for the Seahawks was -115 (BetMGM). Arizona was catching as many as 1.5 (-110) against the spread at bet365. The total was sitting at 43.5 with the under slightly favored at most books.

SEA vs ARI Odds Movement

The spread has moved roughly three points in Seattle’s favor, signaling that sharp money expects the Seahawks to control the game against an Arizona team that’s shorthanded on both sides of the ball.

The Arizona moneyline opened at -120 and is now even-money or longer at most books.

The total hasn’t budged from 43.5 O/U.