Skip to content

Vikings vs Chargers Picks, Predictions & Closing Odds

Chris Amberley

By Chris Amberley in NFL News

Published:


Justin Jefferson celebrates a catch versus the Eagles.
Oct 19, 2025; Minneapolis, Minnesota, USA; Minnesota Vikings wide receiver Justin Jefferson (18) reacts after a play against the Philadelphia Eagles during the second half at U.S. Bank Stadium. Mandatory Credit: Brad Rempel-Imagn Images
  • The Chargers are 3.5-point favorites over the Vikings on Thursday Night Football
  • LA ranks 30th in successful run rate allowed, and has the third worst pass rush grade
  • See below for my Vikings vs Chargers picks and predictions, plus the closing lines

Two teams desperate for a victory square off on Thursday Night Football as the Vikings (3-3, 2-1 away) visit the Chargers (4-3, 2-2 home). The spread has fluctuated between LA -3 and -3.5 all week per the TNF odds, and I’m looking to back the underdog in what should be a high-scoring game.

Kickoff is scheduled for 8:15 pm ET / 5:15 pm PT from SoFi Stadium, in Inglewood, CA, and on Amazon Prime.

Vikings vs Chargers Picks

Minnesota’s offense has been a major disappointment so far, but this is a get right spot. I’m betting Justin Jefferson and Co. +3.5 as my favorite Vikings vs Chargers pick, as the Vikes have exploitable matchups on the ground and through the air.

LA Chargers Defense

StatRank
Successful Run Rate Allowed30th
Yards Per Carry Allowed30th
PFF Pass Rush Grade30th

Let’s start with the LA run defense, that’s been gashed by the Dolphins and Colts in consecutive weeks. The Chargers rank 30th in successful run rate allowed, yards per carry and explosive runs surrendered. That’s good news for Jordan Mason and the middling Minnesota rushing attack, that grades out in the bottom-11 per PFF.

When the Vikings run game is successful, it’s usually a good indicator of success. Minnesota is 3-0 this season when they average at least 3.9 yards per carry.

As for the Chargers pass defense, it’s nearly as underwhelming as their play versus the run. LA is 30th in pass rush grade per PFF, and in the bottom half of the league in pressure rate. That means Carson Wentz should have plenty of time to operate, and few quarterbacks have a better wide receiver duo to throw to in Justin Jefferson and Jordan Addison.

Keeping the pocket clean for Wentz is paramount for his success. Wentz’s passing grade falls from 67.6 to 35.4 under pressure, while his completion percentage dips from 71% to 56%.

Vikings vs Chargers Predictions

The Chargers Super Bowl odds are fading due to their defensive play, but there’s still plenty to like about their offense. Justin Herbert leads the NFL in passing yards (1,913) and has already thrown 13 TD.

He’ll be under constant pressure tonight thanks to a banged up offensive line and the Minnesota blitz-happy defensive scheme, but that suits him just fine. Herbert has the fourth best passing grade under pressure, and averages just as many yards per attempt under duress as he does when kept clean.

His ability to deal with a muddy pocket is why I like LA’s chances to help take this game over the total. The last time he faced a Flores defense, Herbert went for 405 yards and 3 TD.

Looking for more Texans vs Seahawks plays? Check out the following:

MIN Vikings vs LA Chargers Closing Odds for TNF

As always, make sure you check out the best football betting apps before placing a wager on tonight’s game. The best spot to bet Minnesota +3.5 is at BetMGM, as most other books have dropped the spread back down to a field goal.

Bet365 is offering the best odds on a Vikings upset or over 44.5, while DraftKings has the most favorable Chargers moneyline at -170.

DRAFTKINGS SPORTSBOOK

Sign Up Today & Receive Up to
$1,050 in Bonuses!
GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS).
LOCK IN PROMO
SIGNUP PROMO
SIGN UP
& GET $1,050

BONUS BETS + DEPOSIT BONUS

GET PROMO
Odds as of Oct. 23 at 5:30 pm ET. Claim the DraftKings promo code before wagering on Thursday Night Football.

Per the NFL public betting trends, Vikings +3.5 is shaping up to be a popular wager. Minnesota is 14-6 ATS in their last 20 road games, while LA has gone four straight games without covering.

  • BETMGM SPORTSBOOK

    USE CODE SBD1500 & GET $1,500 BACK IN BONUS BETS

  • BET365 SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS WITH CODE DIME365!

  • FANATICS SPORTSBOOK

    BET & GET UP TO $1,000 IN FANCASH!

  • DRAFTKINGS SPORTSBOOK

    BET $5 & GET $300 IN BONUS BETS IF YOUR BET WINS + 3 MONTHS OF NBA LEAGUE PASS

  • FANDUEL SPORTSBOOK

    BET $5 & GET $300 IF YOUR BET WINS!

  • CAESARS SPORTSBOOK

    USE CODE SBD20X & BET $1 TO DOUBLE THE WINNINGS ON YOUR FIRST 20 WAGERS!

  • ESPN BET SPORTSBOOK

    USE CODE DIME TO UNLOCK BET $10, GET $100 BONUS & ESPN+

  • DRAFTKINGS SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS).

  • BET365 SPORTSBOOK T&Cs: Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply. GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ only (18+ KY).

  • BETMGM SPORTSBOOK T&Cs: Gambling problem? Call 1-800-GAMBLER (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

Chris Amberley
Chris Amberley

Sports Writer

As SBD's resident Swiss Army Knife, Chris covers virtually every sport including NFL, PGA, NBA, MLB, NCAAB, NCAAF and the Olympics. A true grinder, he'd rather pick off small edges in the player props market than swing for the fences with a 5-leg parlay.

NFL NBA MLB NHL Golf NCAAF NCAAB Tennis

Recommended Reading