Opening NFL Week 11 Odds – Spread, Total, Moneyline for All Games

• The NFL Week 11 odds have already started to trickle out
• Just two teams (Colts, Saints) are on bye, leaving 15 games for bettors to feast on
• See the opening NFL Week 11 odds, including the spread, moneyline, and total for each game

The NFL Week 11 schedule is the best of the year so far, featuring four heavyweight tilts with massive playoff implications. Online sportsbooks have already started to post the NFL Week 11 odds, which start with an AFC East mismatch on TNF between the New England Patriots (8-2) and New York Jets (2-8), and culminate with a Monday Night Football battle between two underperforming teams: Dallas Cowboys (3-5-1) and Las Vegas Raiders (2-7).

In between, fans will be treated to several marquee matchups: Tampa Bay Buccaneers (6-3) vs Buffalo Bills (6-3), Seattle Seahawks (6-2) vs LA Rams (6-2), Kansas City Chiefs (5-4) vs Denver Broncos (7-3), and Detroit Lions (5-3) vs Philadelphia Eagles (6-2). The table below sets out the opening NFL Week 11 odds for all 15 games on the docket.

NFL Week 11 Odds

The biggest spread of Week 11 is in the opening game, where the Patriots (8-2) are 10.5-point home favorites over the Jets (2-8). The highest total on the board so far is 50.5 O/U in Buccaneers vs Bills. The lowest total is a mere 38.5 O/U in Texans vs Titans.

Odds as of Nov. 9th at bet365 and FanDuel. See the latest on bet365 Missouri ahead of launch in December 2025.

Opening Chiefs vs Broncos Odds

Despite Denver’s gaudy 8-2 record and NFL-best seven-game win streak, the Broncos have opened as 3.5-point home underdogs to the Patrick Mahomes and the visiting Kansas City Chiefs (5-4), who lost last time out (28-21 at Buffalo) but will be coming off a bye in Week 11.

Desperation is undoubtedly baked into this opening line. Mahomes and the Chiefs will inevitably see this as a must-win. A loss would drop them 3.5 games back of the division lead and, likely, out of the AFC playoff picture with just seven games remaining.

These AFC West rivals will play again in Kansas City in Week 17.

Opening Seahawks vs Rams Odds

The best game of the week, strictly in terms of win-loss records, is Seahawks vs Rams. If both teams hold onto the big leads they hold in Week 10, they will enter Week 11 with identical 7-2 records and tied atop the NFC West.

The Rams have opened as modest 2.5-point home favorites and -144 on the moneyline. Seattle comes back as a +124 road underdog. Alongside the Patriots, the Seahawks are one of just two teams that’s perfect on the road this season, going 5-0 straight-up so far.

This Seahawks and Rams will meet again in Seattle in Week 16 in another game that’s sure to have massive playoff implications.

Opening Buccaneers vs Bills Odds

Two Super Bowl contenders coming off disappointing Week 10 results meet in Week 11 when the Tampa Bay Buccaneers (6-3) visit the Buffalo Bills (6-3) in Orchard Park. The Bills lost 30-13 to the 3-7 Miami Dolphins in Week 10 as 8.5-point road favorites. Tampa Bay lost 28-23 at home to New England as 2.5-point home chalk.

The Bills, who are 14-1 in their last 15 home games, have opened as sizable 5.5-point favorites. As mentioned above, this game has the highest total of the week so far at 50.5 with -110 odds both ways.