NFL Week 16 ATS Picks & O/U Predictions from A.I. Model on 61-52 Run

• I have generated the NFL ATS and O/U picks for all 16 games in Week 16 from our internal A.I.
• After a brutal start to the season, the A.I. is 30-26-1 ATS and 31-26 O/U over the last four weeks
• See NFL ATS picks and O/U predictions for Week 16

Aside from tonight’s MNF game, just three weeks remain in the regular season. Our internal A.I. is coming off another decent week (8-6 ATS, 7-7 O/U) and is now 61-52-1 in total over the last four weeks (53.51% hit rate).

The table below sets out the A.I.’s Week 16 picks, including its ATS and O/U pick for all 16 games on the docket. Under the table, I have set out its reasoning for each pick.

NFL Week 16 Picks ATS

The A.I. is backing a stunning 13 favorites in Week 16, and only three underdogs. It went with six underdogs in Week 15 and was a solid 4-2 ATS on those bets.

Its Week 16 O/U picks are more evenly divided with nine under bets and seven over bets.

• A.I. regular-season ATS record: 92-100-1
• A.I. regular-season O/U record: 89-104

Los Angeles Rams vs Seattle Seahawks Picks

A.I reasoning: “This NFC West divisional clash features two explosive offenses in what projects as a high-scoring Thursday night affair. The model identifies Los Angeles as the superior road team, capable of navigating the hostile Seattle environment.

The decisive factor lies in ball security and red zone execution. The Rams maintain an impressive +8 turnover differential while committing a league-low 0.86 giveaways per game. Seattle struggles comparatively with a -2 differential, coughing up the football 1.64 times per contest. Inside the 20-yard line, Los Angeles converts 66.7% of their red zone opportunities into touchdowns compared to Seattle’s 57.4% efficiency rate. Both offenses rank among the league’s elite in scoring (Rams 30.0 PPG, Seahawks 28.9 PPG), but the Rams’ superior ball protection and red zone precision provide the edge in a tight spread. The over becomes attractive given both teams’ offensive capabilities and recent scoring trends.”

• ATS Pick: Rams -1.5
• Over/Under Pick: Over 44.5

Philadelphia Eagles vs Washington Commanders Picks

A.I reasoning: “This NFC East showdown pits Philadelphia’s balanced attack against Washington’s opportunistic defense in what the model projects as a lower-scoring divisional battle.

Philadelphia’s edge stems from their superior offensive line play and third-down efficiency. The Eagles convert 44.2% of their third-down attempts while Washington struggles at just 35.8%. In the trenches, Philadelphia allows 2.1 sacks per game compared to Washington’s 2.8, providing better pocket presence for their quarterback. Defensively, both units have shown vulnerability, but the Eagles’ ability to control the line of scrimmage and sustain drives gives them the advantage. The under appeals due to divisional familiarity and both teams’ tendency toward conservative game plans in meaningful December contests.”

• ATS Pick: Eagles -6
• Over/Under Pick: Under 45.5

Green Bay Packers vs Chicago Bears Pick

A.I reasoning: “The NFL’s oldest rivalry takes center stage in this NFC North battle, with the model backing the visiting Packers to handle Chicago’s opportunistic defense.

Green Bay’s advantage lies in their elite offensive efficiency and ball protection. The Packers convert an exceptional 50.3% of their third downs and score touchdowns on 64.7% of their red zone visits. This will be tested by Chicago’s defense, which has generated a league-best +20 turnover differential, forcing 2.14 turnovers per game. However, Green Bay’s disciplined offense commits just 0.71 turnovers per contest, neutralizing the Bears’ primary strength. Defensively, the Packers hold a clear advantage, allowing only 20.07 points per game compared to Chicago’s 24.14. The under becomes attractive due to Green Bay’s methodical offensive approach and Chicago’s defensive-minded game plans.”

• ATS Pick: Packers -1.5
• Over/Under Pick: Under 46.5

Buffalo Bills vs Cleveland Browns Picks

A.I reasoning: “Buffalo’s dominance stems from their explosive offensive capabilities and defensive pressure. The Bills average 28.7 points per game while generating 2.3 sacks per contest, creating both scoring opportunities and field position advantages. Cleveland’s offense has been inconsistent, managing just 20.1 points per game while struggling with third-down conversions at 37.2%. The Bills’ ability to force quick three-and-outs and capitalize with short fields makes them well-positioned to cover the substantial spread. The under appeals given Cleveland’s offensive limitations and Buffalo’s ability to control tempo.

• ATS Pick: Bills -10
• Over/Under Pick: Under 42.5

Cincinnati Bengals vs Miami Dolphins Picks

A.I reasoning: “Cincinnati’s aerial assault, led by their elite receiving corps, should exploit Miami’s vulnerable secondary that allows 8.2 yards per pass attempt. The Bengals average 26.8 points per game and convert 46.1% of their third downs, creating sustained scoring drives. Miami’s offense has been explosive at home, averaging 25.3 points per game with 7.1 yards per play. Both defenses have shown vulnerability to big plays, with Cincinnati allowing 24.8 points per game and Miami surrendering 23.9. The model favors Cincinnati’s superior offensive weapons while expecting both teams to find the end zone frequently.”

• ATS Pick: Bengals +1.5
• Over/Under Pick: Over 50.5

Los Angeles Chargers vs Dallas Cowboys Picks

A.I reasoning: “The Chargers’ advantage lies in their defensive efficiency and ball control. Los Angeles forces 1.8 turnovers per game while committing just 1.1, creating favorable field position battles. Their defense allows only 21.2 points per game compared to Dallas’s 26.1. Offensively, the Chargers may lack explosive plays but maintain consistency with 41.3% third-down conversions. Dallas has been prone to defensive breakdowns, particularly against methodical ground attacks, which plays into Los Angeles’s strengths. The over becomes attractive given both teams’ ability to move the ball and Dallas’s tendency toward high-scoring home games.”

• ATS Pick: Chargers +1.5
• Over/Under Pick: Over 49.5

New York Jets vs New Orleans Saints Picks

A.I reasoning: “New Orleans holds advantages in offensive efficiency and home-field atmosphere. The Saints convert 43.8% of their third downs while the Jets manage just 38.2%, creating more sustained scoring drives. Defensively, New Orleans forces 1.9 turnovers per game compared to New York’s 1.4, providing additional possessions for their offense. The Saints’ home advantage in the Superdome has historically been significant, particularly in December games. The under appeals due to both teams’ offensive limitations and the Saints’ tendency toward conservative game plans at home.”

• ATS Pick: Saints -4.5
• Over/Under Pick: Under 40.5

Tampa Bay Buccaneers vs. Carolina Panthers Pick

A.I reasoning: “Tampa Bay’s edge comes from their veteran leadership and offensive firepower. The Buccaneers average 26.4 points per game while converting 44.7% of their third downs, creating consistent scoring opportunities. Carolina’s defense has been vulnerable to explosive plays, allowing 7.8 yards per pass attempt. The Panthers have shown fight at home but lack the offensive weapons to match Tampa Bay’s aerial attack. Both teams have defensive vulnerabilities, suggesting a higher-scoring divisional battle where Tampa Bay’s superior talent prevails.”

• ATS Pick: Buccaneers -2.5
• Over/Under Pick: Over 45.5

Minnesota Vikings vs New York Giants Picks

A.I reasoning: “The Vikings’ advantage lies in their balanced offensive attack and defensive pressure. Minnesota generates 2.4 sacks per game while forcing 1.7 turnovers, creating short fields for their offense. The Giants have struggled with ball security, turning the ball over 1.6 times per contest while managing just 19.8 points per game. Minnesota’s ability to control the line of scrimmage on both sides creates multiple advantages in what projects as a defensive battle. The under becomes attractive given the Giants’ offensive limitations and Minnesota’s methodical approach.”

• ATS Pick: Vikings -2.5
• Over/Under Pick: Under 44.5

Kansas City Chiefs vs Tennessee Titans Picks

A.I reasoning: “Kansas City’s championship experience and clutch-gene factor provide significant advantages in close games. The Chiefs convert 45.2% of their third downs while Tennessee manages just 36.9%, creating more sustained drives. Defensively, Kansas City forces 1.8 turnovers per game compared to Tennessee’s 1.2, generating additional possessions. The Chiefs’ ability to elevate their play in crucial moments gives them the edge to cover the modest spread. The under appeals due to Tennessee’s offensive limitations and both teams’ tendency toward conservative approaches.”

• ATS Pick: Chiefs -3.5
• Over/Under Pick: Under 37.5

Jacksonville Jaguars vs Denver Broncos Picks

A.I reasoning: “Denver’s advantage stems from their home-field altitude and defensive pressure. The Broncos generate 2.2 sacks per game while forcing 1.9 turnovers, creating favorable field position. Jacksonville’s offense has struggled with consistency, managing just 21.7 points per game while committing 1.5 turnovers per contest. Denver’s ability to control the ground game and maintain possession gives them the edge in a low-scoring affair. The under becomes attractive due to both teams’ offensive limitations and Denver’s defensive capabilities.”

• ATS Pick: Broncos -3
• Over/Under Pick: Under 45.5

Atlanta Falcons vs Arizona Cardinals Picks

A.I reasoning: “Atlanta’s edge lies in their more consistent offensive production and superior red zone efficiency. The Falcons score touchdowns on 61.2% of their red zone opportunities compared to Arizona’s 54.8%, maximizing their scoring chances. Atlanta’s ground game averages 4.6 yards per carry, creating favorable third-down situations. Arizona has been vulnerable to balanced offensive attacks, particularly struggling against teams that can establish the run early. Both offenses possess explosive capabilities, suggesting a higher-scoring affair where Atlanta’s consistency prevails.”

• ATS Pick: Falcons -2.5
• Over/Under Pick: Over 46.5

Las Vegas Raiders vs Houston Texans Picks

A.I reasoning: “This AFC matchup features the largest spread of the week, with Houston laying substantial points against a struggling Raiders team.

The Texans’ overwhelming advantages span both sides of the ball. Houston averages 27.1 points per game while allowing just 20.4, creating a seven-point differential that supports the large spread. Las Vegas has been particularly vulnerable on the road, averaging just 18.6 points per game away from home while surrendering 28.3. Houston’s defensive pressure generates 2.5 sacks per game, creating negative plays and short fields for their offense. The under appeals despite the large spread due to Houston’s ability to control tempo and Las Vegas’s offensive limitations.”

• ATS Pick: Texans -14.5
• Over/Under Pick: Under 37.5

Pittsburgh Steelers vs Detroit Lions Picks

A.I reasoning: “Detroit’s advantage lies in their explosive offensive capabilities and home-field energy. The Lions average 31.2 points per game while converting 47.8% of their third downs, creating consistent scoring opportunities. Pittsburgh’s defense has shown vulnerability to quick-strike offenses, particularly those utilizing multiple receiving threats. While the Steelers bring physicality and playoff experience, Detroit’s superior offensive firepower and home crowd provide the edge to cover the touchdown spread. The over becomes attractive given Detroit’s offensive explosion and Pittsburgh’s ability to respond with scoring drives.”

• ATS Pick: Lions -7
• Over/Under Pick: Over 49.5

New England Patriots vs Baltimore Ravens Picks

A.I reasoning: “The Patriots have shown resilience in road spots, particularly against teams with playoff aspirations. Baltimore’s offense has been inconsistent, averaging 23.8 points per game while struggling with red zone efficiency at 56.3%. New England’s defense forces 1.6 turnovers per game, creating short fields for their offense. The over appeals due to both teams’ ability to move the ball and the potential for a competitive, back-and-forth affair.”

• ATS Pick: Patriots +2.5
• Over/Under Pick: Over 48.5

San Francisco 49ers vs Indianapolis Colts Picks

A.I reasoning: “San Francisco’s advantage lies in their superior talent across all position groups and playoff experience. The 49ers average 25.9 points per game while converting 44.1% of their third downs, creating sustained scoring drives. Indianapolis has been vulnerable to explosive offensive attacks, particularly those featuring multiple weapons. San Francisco’s defensive pressure generates 2.1 sacks per game while forcing 1.8 turnovers, creating favorable field position. The under becomes attractive due to the 49ers’ ability to control tempo and Indianapolis’s offensive limitations against quality defenses.”

• ATS Pick: 49ers -5.5
• Over/Under Pick: Under 46.5