NFL Week 17 AI Picks Against the Spread: Expert Predictions and Betting Analysis

• I have generated A.I. NFL picks (ATS and O/U) for all Week 17 games
• The A.I. is 37-33-1 ATS and 39-32 O/U over the last five weeks, but still well under .500 for the year
• See the Week 17 ATS picks and O/U predictions from our internal A.I.

Our A.I.’s strong second half continued on Sunday, with the model going a game over .500 on its 32 picks for last Week. The model is now 37-33-1 ATS and 39-32 O/U over the last five weeks of NFL action.

I have already generated its ATS and O/U picks for all NFL Week 17 games. Remember, Week 17 is front-loaded with three games on Christmas (Thursday, Dec. 25) and two more on Saturday, Dec. 27.

The table below lists the A.I.’s picks for each Week 17 game, set out in chronological order. Under the table, find the A.I.’s explanation for select picks.

NFL Week 17 ATS Picks & O/U Predictions

The A.I. has an even split between favorites and underdogs this week, which is a rarity. (It usually leans chalk.) The game-total divide is almost even with nine overs and seven under bets.

• A.I. regular-season ATS record: 99-107-1
• A.I. regular-season O/U record: 97-110

Week 17 ATS & O/U Picks Analysis & Breakdowns

Dallas Cowboys @ Washington Commanders Picks

• ATS Pick: Dallas Cowboys -6.5
• O/U Pick: Over 50.5

A.I. explanation: “The Cowboys, a strong offensive unit, are facing a struggling Commanders team. While divisional games can be tricky, the 5.5-point spread seems manageable for Dallas given their recent form and the Commanders’ defensive woes. The high total of 50.5 reflects the Cowboys’ ability to put up points, and their games often lean towards the over.”

Detroit Lions @ Minnesota Vikings Picks

• ATS Pick: Minnesota Vikings +5.5
• O/U Pick: Over 44.5

A.I. explanation: “The Lions are strong, but giving 5.5 points on the road in a divisional game against a resilient Vikings team can be risky. Minnesota’s ability to stay competitive, especially at home, makes them an attractive underdog here. The 44.5 total is moderate; both teams have offenses capable of hitting the over, and defensive lapses could lead to a higher-scoring affair.”

Denver Broncos @ Kansas City Chiefs Picks

• ATS Pick: Kansas City Chiefs +13.5
• O/U Pick: Over 37.5

A.I. explanation: “The 13.5-point spread represents a massive overreaction to recent performances in this AFC West clash. While the Chiefs have struggled against the spread, failing to cover in their last five games, this line offers too many points for a divisional matchup. The offensive output disparity is minimal, with Denver averaging just 1.4 more points per game (23.6 to 22.2). Defensively, these teams mirror each other statistically, as Kansas City allows 19.60 PPG compared to Denver’s 19.67 PPG allowed.

The Broncos’ elite pass rush generates 63 sacks on the season, creating consistent pocket pressure. However, this advantage alone doesn’t justify such a wide margin against a defense that matches their statistical profile. The total has been hammered down to 37.5, creating significant value on the over. Denver’s offense has found rhythm lately, with their games eclipsing the total in four of their last five contests. The combined scoring average for these squads reaches 45.8 PPG, suggesting even pedestrian offensive performances should surpass this depressed number.”

Houston Texans @ Los Angeles Chargers Picks

• ATS Pick: Los Angeles Chargers -1.0
• O/U Pick: Over 39.5

A.I. explanation: “The Chargers are slight home favorites against the Texans, who have shown flashes of potential. With a small spread of -1.0, the home-field advantage often plays a crucial role. The total of 39.5 is relatively low, but both offenses have the capability to contribute to a higher-scoring game, especially if defensive lapses occur.”

Baltimore Ravens @ Green Bay Packers Picks

• ATS Pick: Ravens +3.5
• O/U Pick: Under 45.5

A.I. explanation: “The total for this game has plummeted, suggesting bettors anticipate a gritty defensive struggle. Both teams have strong defenses, making an ‘Under’ pick a sensible choice..”

Pittsburgh Steelers @ Cleveland Browns Picks

• ATS Pick: Cleveland Browns +4.5
• O/U Pick: Under 34.5

A.I. explanation: “This AFC North clash promises to be a defensive battle, reflected in the extremely low total of 34.5. The Browns, playing at home, are a tough out and getting 4.5 points against a Steelers team that can struggle offensively makes them an attractive underdog. Expect a grind-it-out game with limited scoring opportunities.”

Arizona Cardinals @ Cincinnati Bengals Picks

• ATS Pick: Cincinnati Bengals -7
• O/U Pick: Over 53.0

A.I. explanation: “The Bengals are strong favorites at home against the struggling Cardinals. While a 7-point spread can be tricky, the Bengals’ offensive firepower should be more than enough to cover against a weak Cardinals defense. The high total reflects the potential for a high-scoring affair, driven by the Bengals’ offense.”

New Orleans Saints @ Tennessee Titans Picks

• ATS Pick: Tennessee Titans +3.0
• O/U Pick: Under 39.5

A.I. explanation: “The Saints are favored on the road, but the Titans are a tough team at home, especially with a 3-point cushion. Both teams tend to play a more conservative, run-heavy style, and the low total of 38.5 suggests a defensive battle. Expect a tight game with limited scoring.”

Jacksonville Jaguars @ Indianapolis Colts Picks

• ATS Pick: Indianapolis Colts +7.0
• O/U Pick: Under 46.5

A.I. explanation: “The Jaguars have been dominant, winning and covering in all five of their last contests. However, laying 6.5 points on the road against a division rival presents significant challenges. Indianapolis holds statistical advantages in crucial offensive categories, posting superior points-per-game output (27.7 vs. 27.1), better third-down conversion efficiency (41.5% vs. 38.1%), and improved red zone effectiveness (64.9% vs. 61.7%).

Jacksonville’s defense allows just 20.80 PPG while maintaining an excellent +10 turnover differential. Despite these strengths, the Colts’ offensive efficiency combined with home-field advantage should keep this contest within a single score. The under presents value despite both teams fielding explosive offenses. Divisional games in late-season scenarios typically evolve into defensive battles, with Indianapolis particularly stout against ground attacks, surrendering only 95.14 rushing yards per game. Expect both defensive units to limit explosive plays and keep scoring below the 46.5-point threshold.”