NFL Week 7 Odds – Opening Lines and Spreads for All Games

• Week 7 of the NFL season opens Thursday night with the Browns hosting the Broncos
• The Cardinals are the biggest favorites as 16.5-point home choices over the Texans
• All the Week 7 opening lines and spreads can be found below

Week 7 of the NFL season begins Thursday night when the Cleveland Browns host the Denver Broncos.

The Browns have opened as 5.5-point favorites despite getting smoked at home by the Arizona Cardinals 37-14 on Sunday. Back-to-back losses have dropped Cleveland’s record to 3-3. The Broncos (3-3) have lost three in a row since beginning the season on a three-game winning streak and fell 34-24 to the Raiders on Sunday in Denver.

Sunday Night Football features the Indianapolis Colts visiting the San Francisco 49ers. San Francisco is a 5.5-point favorite.

The Seattle Seahawks host the New Orleans Saints on Monday Night Football and are 3-point underdogs at Lumen Field.

Here is a look at all the NFL Week 7 lines:

NFL Week 7 Opening Odds

Odds as of October 17th at FanDuel.

Unbeaten Cards Huge Favorite

Coming off their rout of the Browns, the Cardinals are the biggest favorites on the board this week. Arizona is a 16.5-point choice at home over the Houston Texans.

Kyler Murray threw four touchdown passes as the Cardinals remained the NFL’s only unbeaten team and continued their best start since 1974.

Complimentary football baby

🗣 @buddabaker32 pic.twitter.com/HSGNYsELiy

— Arizona Cardinals (@AZCardinals) October 18, 2021

The Cardinals (6-0) built a 20-0 lead in the first half and kept their perfect record intact despite not having coach Kliff Kingsbury or star edge rusher Chandler Jones. Both tested positive for COVID-19 this week.

Murray connected with DeAndre Hopkins for two touchdowns.

The Texans (1-5) were routed 31-3 by the Colts at Indianapolis, losing their fifth straight game. Houston was down just 10-3 at halftime but were outscored 21-0 over the final two quarters.

Houston gave up two touchdown passes to Carson Wentz and two TD runs to Jonathan Taylor.

Hot Take: Jonathan Taylor is a good football player.

📺 CBS pic.twitter.com/gIwoZLHykC

— Indianapolis Colts (@Colts) October 17, 2021

Falcons Slight Road Picks

The smallest spread is the 1.5 points the Atlanta Falcons (2-3) are favored against the Miami Dolphins (1-5) on the road.

The Falcons were off this weekend after beating the New York Jets 27-20 in London last Sunday. Atlanta has won two of its last three games following an 0-2 start.

The Jets couldn’t quite catch up and the Falcons take home a W from London 🇬🇧

(🎥 via @NFL)

pic.twitter.com/FmWTzoEtUK

— The Sporting News (@sportingnews) October 10, 2021

London wasn’t so kind to the Dolphins on Sunday as they fell to the previously winless Jacksonville Jaguars 20-17 at Tottenham Hotspur Stadium despite the return of quarterback Tua Tagovailoa.

The loss was the fifth in a row for Miami and came when Jacksonville’s Matthew Wright kicked a 53-yard field goal as time expired.

Tagovailoa was back after he missed three games with a rib injury. He threw two touchdown passes to Jaylen Waddle, his former college teammate at Alabama.

.@Tua + @D1__JW = 6️⃣@MiamiDolphins lead early in London! #FinsUp

📺: #MIAvsJAX on CBS
📱: NFL app pic.twitter.com/2n7INZnFuX

— NFL (@NFL) October 17, 2021

Highs and Lows

The 56.5-point total for the Kansas City Chiefs’ visit to the Tennessee Titans is the biggest over/under on the slate.

That should not be a surprise considering the Chiefs are scoring and allowing a lot of points. Kansas City is averaging 30.8 a game on offense and giving up 29.3.

.@patrickmahomes airs it out @demarcus for the SCORE!!! 🚀

📺: #KCvsWAS on CBS pic.twitter.com/OVkxT6P4Hq

— Kansas City Chiefs (@Chiefs) October 17, 2021

The Titans’ averages are 26.4 and 26.0.

The lowest over/unders are 43.5 for the New York Jets-New England Patriots game in Foxborough, as well as Broncos-Browns and Saints-Seahawks.

Out of Line?

While it’s hard to discern which team is better between the Falcons and Dolphins, Atlanta being favored by 1.5 points on the road seems a little high. Look for some money to go Miami’s way, especially with Tagovailoa back.

Considering they are just 2-4, perhaps it shouldn’t be surprising that the Patriots are just 7-point picks over the Jets. However, the Jets are the J-E-T-S and Bill Belichick is still Bill Belichick, so look for the public to bet this line up.