Cardinals vs Cowboys Picks & Closing Odds

• The Dallas Cowboys are 3.5-point home favorites vs the Arizona Cardinals on MNF
• Arizona QB Kyler Murray (foot) will not start
• Keep reading for my Cardinals vs Cowboys picks and predictions, plus closing odds

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Two teams trying to work their way into the NFC playoff picture battle on Monday Night Football, as the Dallas Cowboys (3-4-1, 4-4-0 ATS) host the Arizona Cardinals (2-5, 4-3-0 ATS).

Arizona, who has lost five in a row and will be without starting QB Kyler Murray, isn’t as large an underdog you’d think in the NFL odds.

Kickoff is set for 8:15pm ET from AT&T Stadium in Arlington, TX with ABC carrying the broadcast.

Cardinals vs Cowboys Picks & Prediction

I believe there’s value in targeting the total, and why I’m taking the Over for my Cardinals vs Cowboys prediction.

Each of Dallas’ last five games has climbed to at least a combined 57 points.

Arizona might 3-2-0 against the spread during a 5-game losing skid, but without Kyler Murray, there’s always a risk that a backup QB, despite showing well, can turn back into a pumpkin.

The Cowboys are an elite offensive unit particularly at home, where they are putting up 441 yards per game and a blistering 41.3 scoring average.

Dak Prescott is playing at an MVP level, leading the league with 204 completions, tied for tops with six 40-plus yard completions, while tossing 16 TDs.

Unfortunately, for them, they are giving plenty back on the defensive side this year, as they’ve surrendered 30 touchdowns and 250 points at the 8-game mark.

That’s nearly on pace of last year’s record-setting performance of futility from the Carolina Panthers (534 points allowed)

Arizona might be just outside the Bottom-10 in scoring in the NFL, but they’ve been much better of late, cashing the Over in three straight games.

Trey McBride spins out for his 2nd TD of the game!

GBvsAZ on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/yyceqyLKyh

— NFL (@NFL) October 19, 2025

The last two of those have been with veteran backup Jacoby Brissett under center, and he’s guided them to an average of 25 points per game.

He’ll be aided by a Cowboys defense that has surrendered at least 30 points in five of eight games, and was just torched for 44 points – the third time a team has cracked 40 on them.

They’re also far from healthy: S Donovan Wilson (elbow/shoulder), S Alijah Clark (ribs), CB Shavon Revel (knee), LB Jack Sanborn (groin), LB DeMarvion Overshown (knee) and DT Perrion Winfrey (back) are all out.

Cardinals vs Cowboys Closing Lines

Closing in on two hours before kickoff, the Cowboys are -175 moneyline favorites, and 3-point favorites over at FanDuel. Arizona is +154 on the moneyline and if you’re betting the Cardinals, you can get an extra half-point at DraftKings. The best total for the Over is currently 53.5 points, while Under bettors can find the Over at 54.5 points.

The interactive table above will automatically update as the NFL betting odds move over the course of the day.

Cardinals vs Cowboys Line Movement

The line hasn’t ventured very far from the 2.5-point spread set in the Week 9 opening lines, as its currently mostly at a 3.5-point spread.

The books have had two weeks to see backup Jacoby Brissett navigate the Cardinals’ offense, and it’s been impressive. That and Dallas’ porous defense has likely kept this line in range.

The moneyline moves are minimal as well, with Arizona hovering around the +150 mark, up from the +120 to +130 range earlier in the week. The Cowboys are currently in the -180 range as the betting favorite, from -140ish earlier on.

Are the Cardinals the bet tonight? 🤔

Arizona is 7-1 SU in their last eight vs Dallas

Arizona is 3-0 ATS in road games this year

The Cardinals are 7-1 ATS in their last eight as road underdogs pic.twitter.com/IGsxfzwN9G

— SportsBettingDime (@SBD) November 3, 2025

As for the total, it has stopped (for now) at 54.5 points, moving on up from as low as 51.5 points in the leadup.

It’s still pretty generous, as Dallas offers assistance on both sides of this score: they are second in the NFL in scoring, while ranking second in points allowed.

The NFL public betting percentages like the Cowboys to cover at a 3-point line, with 74% o bets and 66% of the money on that line.

A Dallas outright win is getting hammered, with 91% of the bets and 90% of the money siding with the home team.

The total splits are telling: just 20% of the bets are taking the Over, but 63% of the money is dropped on the Over, while only 37% of the money is on 80% of the bets to stay Under 54.5 points.

ARI vs DAL Betting Trends

• The Cardinals have won seven of their last eight meetings vs Dallas.
• Arizona is 3-0 against the spread on the road this season and 7-1 ATS as road underdogs since 2024.
• The Cowboys’ past five games have gone over the total – including three straight at home.
• Dallas has yet to lose at home this season, going 2-0-1 in three games and 2-1-0 ATS.
• The Cardinals have lost five straight, with the margin being no larger than four points in any of them.