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Buffalo vs Central Michigan Prediction, Spread & Pick for Wednesday

Eric Rosales

By Eric Rosales in College Football

Published:


Ta'Quan Roberson celebrating
Aug 28, 2025; Minneapolis, Minnesota, USA; Buffalo Bulls quarterback Ta'Quan Roberson (2) celebrates wide receiver Victor Snow's (0) touchdown catch against the Minnesota Golden Gophers during the second half of the game at Huntington Bank Stadium. Mandatory Credit: Matt Krohn-Imagn Images
  • The Central Michigan Chippewas are 1.5-point favorites vs the Buffalo Bulls on Tuesday
  • The Bulls are seeking their fourth win in five games
  • See below for my Buffalo vs Central Michigan prediction, picks and line

Two teams battling at the top of the MAC collide Tuesday night when the Buffalo Bulls (5-4, 4-1 MAC) visit the Central Michigan Chippewas (5-4, 3-2 MAC).

Buffalo is one of four school log jammed at the top of the MAC with 4-1 records, while Central Michigan is in a group of three a game back at 3-2, and they’re favored by 1.5 points in the college football odds.

In a matchup that’s really tough to call, my Buffalo vs Central Michigan prediction is leaning on the Chippewas’ standout play at home to prevail.

Kickoff is scheduled for Tuesday night at 7pm ET from the Kelly/Shorts Stadium in Mount Pleasant, MI. CBS Sports Network is providing the broadcast coverage.

Buffalo vs Central Michigan Prediction

These teams are pretty evenly matched statistically, with Buffalo ranking inside the Top four in both scoring offense (24.8ppg) and defense (19.6ppg).

The Bulls are coming off one of their best wins of the season, mashing Bowling Green 28-3. That’s the only non-stress game they’ve been involved in through five conference games.

In their four other games, the margin for win or defeat has been nothing greater than eight points.

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Central Michigan is right in Buffalo’s wheelhouse, a few notches back. in the standings, but inside the Top Six in both, scoring 24.1 points per game, while giving up a few more points at 24 per contest.

The Chippewas are coming off a 24-21 loss to Western Michigan, dropping them to 3-2 in conference play.

They’ve been within one possession in both MAC losses (they dropped a 28-22 decision to Akron), but they’ve been dominant in victory winning by double digits in all three wins.

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While Buffalo does a little bit of run and pass, the Bulls do what they can to navigate a game and finish it off with a win.

There’s no mistaking Central Michigan’s MO: they are the second-leading rushing team in the conference, and they run relentlessly, ringing up 185.3 yards per game.

Buffalo does rank fourth in the MAC defending the run, but they haven’t faced any team in the Top 6 until Tuesday. They give up 139 yards per game and have allowed 10 rushing scores, so they’re no exactly dominant, either.

Buffalo vs Central Michigan: Key Offensive Stats

CategoryBuffaloCentral Michigan
Total Offense357.0 YPG (95th)339.0 (109th)
Passing Offense212.6 YPG (92nd)153.6 YPG (126th)
Rushing Offense144.4 YPG (83rd)185.4 YPG (35th)
Scoring Offense24.8 PPG (90th)24.1 PPG (94th)
QB Rating122.4 (104th)167.4 (6th)

Buffalo has rolled in this head-to-head of late, taking three of the last four, and scoring at least 34 points in each of the wins. That’s not who they are now, as they’ve cracked 30+ points just three times this season.

Backing up the Bulls’ bend don’t break kind of season: they are just 1-5-1 against the spread in their last seven games, failing to cover as a favorite all five times.

Central Michigan has been a consistently stronger bet, going 5-1-0 ATS in its last six contests, including a 3-1-0 mark as a favorite.

They’ve also just played three games at home, but the Chippewas have been awesome in front of the home crowd: they’re 3-0, have held their opponent to 13 points or less, while averaging 37 points per game.

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Buffalo vs Central Michigan Odds

The interactive table above will automatically update as the college football odds move over the course of the day.

Buffalo has been as long as 2.5-point underdogs, but that line has closed by a point at most sports books.

Central Michigan ranges as a favorite from a point to 1.5 points across the board, and they’re just -106 moneyline favorites, as opposed to the Bulls, who are +100 underdogs.

The total has been as low as 42.5, and Under bettors can find this line a point higher at sites like BetMGM. The Over has cashed in four of the last five head-to-head meetings.

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Eric Rosales
Eric Rosales

Sports Writer & Editor

Having worked in and around sports since 1997, Eric is truly a knowledgeable expert. The two-time journalism grad specializes in all things NBA and NFL. From TSN.ca to CTV's Olympic Broadcast Consortium, Eric's work has appeared in local and national publications alike.

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