Indiana State vs Indiana Odds, Picks & Predictions (Sep. 12)

• Indiana State heads to Bloomington to take on 22nd-ranked Indiana in Week 3 college football action!
• Right now, the Indiana State vs Indiana odds favor the Hoosiers by 48.5 points
• Read below for Indiana State vs Indiana odds, picks, and prediction

This game asks the question, are all 2-0 records created equally? The Sycamores and Hoosiers are both undefeated. Unfortunately for Indiana State, Indiana is a ranked team with higher aspirations as the Big 10 schedule looms in the not-so-distant future.

Indiana expects to win by a substantial amount with the over/under set at 59.5 points, according to DraftKings Sportsbook. The game will be broadcast live on FS1 and streamed on Fox ONE. Kickoff will be scheduled just after 6:30 p.m. ET.

Indiana State vs Indiana Odds

Indiana is favored by 48.5 points with no moneyline odds, implying a pretty much 100% win probability for the Hoosiers. Indiana State does not expect to shift the spread enough to warrant a moneyline.

The total is set at 59.5 points, with even juice on the Over and Under.

Odds as of September 12, 2025, at DraftKings Sportsbook. Examine the prime College Football betting apps for Indiana State-Indiana.

Indiana State vs Indiana Picks:

Now, when spreads get this outrageous, it can be hard to believe that a college is this much of a favorite. However, if anyone saw Indiana and Indiana State, one instantly sees why. The Hoosiers are a nationally ranked team coming off a college football playoff appearance last season. Indiana State plays in the FBS out of the MVFC, while Indiana is in the Big 10.

Indiana State will be glad to get back to conference play when this game is over. FBS schools can provide much-needed dollars, but the chances of victory are slim to almost none.

The question now is, can Indiana State gain some value from that $475,000? Alright, the real question may be, can they keep this game within 50 points? Curt Cignetti has mentioned the run setting up the pass. Last week against Kennesaw State, the Hoosiers ran 39 times for 313 yards. That included three rushing scores in the 56-9 win.

I am going for the huge leap and looking at Indiana covering with 60+ points scored. It will be very late, but expect the Hoosiers to cover both wagers.

Friday CFB Picks:

• Indiana 48.5 Spread (-110) and Game Total Over 59.5 (-110)

Indiana State vs Indiana Predictions

• Game Winner Prediction: Indiana
• Prop Prediction: Indiana State First Drive Turnover (+399 ML at DraftKings)

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Now, after three weeks, maybe we have our college football betting legs finally. Honestly, Weeks 0-2 featured their share of crazy results. Upsets are part of the game, but it seems each September, we see this too often. Again, I take a big risk this week in going for the Hoosiers in this aggressive manner. After all, the highest margin of victory for Indiana was only 47 points. Both Indiana State opponents had some success running the football. Indiana’s rushing game is a huge part of its offense.

For Indiana State, points can be difficult to come by. Yes, scoring 79 points in two contests is impressive. However, facing a Big 10 team on the road is a little different than FBS I competition. These are just two of the reasons why the spread is so high.

Curt Cignetti and Indiana remain the focus here. This game looms large given the Hoosiers’ schedule over the next three weeks. Illinois comes to Bloomington next Saturday, then Indiana heads to Iowa City and Oregon the following week. Understandably, this week is important.

Indiana now has +550 odds to make the College Football Playoff. More than likely, those numbers will change quite a bit over the next several weeks. Playing two current Top 10 teams often has that impact.

Indiana State vs Indiana Head-to-Head

The programs have indeed met seven times before. Here are how the last four went:

• September 8th, 2023: Indiana 41, Indiana State 7
• August 30th, 2014: Indiana 28, Indiana State 10
• August 29th, 2013: Indiana 73, Indiana State 35
• September 1st, 2012: Indiana 24, Indiana State 17

Unfortunately, with NIL dollars, the matchup two years ago provides little help here.

Expect Indiana to run early and often and probably for over 300 yards again on Friday night.