Opening College Football Week 13 Lines, Odds & Best Bets 2025
By Sascha Paruk in College Football
Published:
- The NCAAF Week 13 odds and betting lines are out
- Week 13 is highlighted by #17 USC vs #8 Oregon
- See the opening college football Week 13 odds for all P4 and ranked teams
After a massive Saturday in which six top-25 teams lost outright, the lines have been posted for NCAAF Week 13.
The Week 13 slate is light on ranked-vs-ranked matchups, but there are a few games that carry big implications for the CFP odds, most-notably #17 USC visiting #8 Oregon. Week 13 also brings the latest iteration in the fierce Florida/Tennessee rivalry
The table below lists the college football Week 13 odds for all games involving power-conference and/or ranked teams.
College Football Week 13 Odds
Still undefeated heading into Week 13, the #1 Ohio State Buckeyes are massive +185 favorites in the latest national championship odds. The #2 Indiana Hoosiers – also undefeated – are a distant +500 second-favorite. Alabama faded from third-favorite to eighth at +1500 after losing at home to Oklahoma.
Odds in the table as of 10:58 am ET, Nov. 16, at DraftKings. See the latest offers from DraftKings Missouri if you live in the Show-Me State.
Early NCAAF Week 13 Picks & Best Bets
Georgia Tech -2.5 (-118) vs Pitt at FanDuel
The most significant advantage belongs to Georgia Tech’s ground attack facing Pittsburgh’s run defense. The Yellow Jackets’ 224.6 rushing yards per game will look to find success against the Panthers’ run defense.
Pittsburgh’s defensive strength lies in generating turnovers, specifically 1.2 interceptions per game. But Haynes King has only tossed two picks all season, and the Yellow Jackets’ run-heavy approach limits his chances to toss picks.
USC +8.5 (-113) at Oregon at Underdog
USC has shown an ability to rise to the occasion when disrespected by oddsmakers. More specifically, the Trojans have a tendency to keep games closer than expected in high-leverage situations when catching 7+ points.
Oregon, despite its home-field advantage, has shown varied ATS results as a home favorite of 7+ points over the past two seasons, suggesting the market overvalues the Ducks’ dominance at Autzen.
Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
