Opening College Football Week 5 Odds, Spreads & Early Picks

• The Week 5 college football odds are out, including #2 Georgia vs #4 Alabama
• Unbeaten Louisville travels to South Bend to face one-loss Notre Dame
• See all the opening college football Week 5 odds including point spread, moneyline. and game total

Week 4 is in the books and all of the top-ten teams survived unscathed. Heading into Week 5 of the college football season, all eyes will be on Tuscaloosa as the #4 Alabama Crimson Tide welcome the #2 Georgia Bulldogs to Bryant-Denny Stadium at 7:30 pm ET. But that’s just one of a handful of games between ranked teams as the season kicks into high-gear this Saturday.

The table below lists the opening NCAAF Week 5 odds for all games currently on the board. More games will be added to the table as odds are released. Under the table, find my favorite early lines to target for Week 5.

Opening College Football Week 5 Odds

In the marquee matchup of the week, Georgia has opened as a 2.5-point road favorite at Alabama. The Tide have only lost one home game since 2019, but that came last year in an early-season tilt with Texas (34-24) on Sep. 9, 2023.

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Odds as of Sep. 22 at FanDuel and ESPN Bet. Download the bets college football betting apps to land a bonus for Week 5. 

Sascha Paruk’s 2024 NCAAF betting record: 7-3 (+3.71 units).

Early NCAAF Week 5 Pick: SMU (-164) over Florida State – 2.0 units

Cal couldn’t quite get it done as my upset pick of Week 4, falling 14-9 to Florida State, but I’m going right back to the fade-the-Noles well in Week 5. This is their first true road game of the season, and their Week 4 win over Cal did nothing to reshape my opinion that FSU is a bad football team. The Seminoles were widely out-gained by the Golden Bears (410-284) and needed multiple red-zone defensive stands in the fourth quarter to secure their first win of the season.

The Mustangs are 3-1 on the season with their only setback a respectable 18-15 loss to undefeated BYU. Dual-threat QB Kevin Jennings took over from prolific passer Preston Stone as QB1 last week, and SMU picked up a  66-42 shootout victory over TCU as one-point home underdogs. They have a much better offense and, while their defense is suspect, Florida State hasn’t shown any consistency moving the ball. Don’t expect that to change in hostile territory in Week 5.