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Tulane vs Ole Miss Prediction, Props & Latest Odds

Nick Holz

By Nick Holz in College Football

Published:


Tulane vs Ole Miss odds
Nov 15, 2025; Oxford, Mississippi, USA; Mississippi Rebels running back Kewan Lacy (5) reacts after a touchdown run during the fourth quarter against the Florida Gators at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images
  • Tulane meets Ole Miss on Saturday, December 20th
  • Tulane is 0-8 SU in their last 8 games against Mississippi
  • Dive into my Tulane vs Ole Miss prediction, with props and all the latest odds

AAC Conference champions Tulane take on Ole Miss in a monumental College Football Playoff first-round clash on Saturday, December 20th.

The Green Wave finished their season with a 34-21 rout of North Texas, while Ole Miss defeated Mississippi State in their closing game. The Green Wave and Rebels are an even 3-5 ATS in their last eight.

Even without Lane Kiffin, the Rebels are 17.5-point favorites with kickoff set for 3:30 pm ET at Vaught-Hemingway Stadium. Catch all the action on TNT.

Check out my Tulane vs Ole Miss prediction, with props and the latest odds.

Tulane vs Ole Miss Prediction

  • Prediction: Ole Miss Wins, Tulane covers +17.5
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Tulane is simply outmatched in both athleticism and depth in this first-round CFP matchup.

The Rebels smoked the Green Wave 45-10 back in September, racking up 548 total yards while holding Tulane to 282. That game was also in Oxford, where Ole Miss is 8-0 this season and outscoring opponents by 22.5 points per game.

Tulane has improved since then and enters this contest on a five-game winning streak. However, even without their playcaller, defensive coordinator Pete Golding will be able to rally his troops.

Ole Miss offensive coordinator Charlie Weis Jr. should coax the best out of quarterback Trinidad Chambliss (3,016 passing yards, 22 TDs) and running back Kewan Lacy (1,279 rushing yards, 20 TDs), and that will be enough to defeat Tulane in this Tulane vs Ole Miss prediction.

However, the Green Wave defense should keep them in this contest. Tulane’s stop unit is 33rd nationally in havoc rate and has created 24 takeaways this season.

Plus, quarterback Jake Retzlaff is fully capable of keeping drives alive with his arm and legs. I like Ole Miss to win this game, but expect the Green Wave to hang around early before the Rebels pull away in the second half.

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Tulane vs Ole Miss Props

PlayerProp BetOdds
Jake RetzlaffUnder 185.5 Passing Yards-114
Kewan LacyTo Score 2+ Touchdowns-120
Lucas CarneiroOver 7.5 Kicking Points-109

Retzlaff has been reliable all season, averaging about 220 passing yards per game. But the Tulane quarterback folded under pressure in the first matchup with just 56 passing yards while under constant pressure.

The Rebels defense is one of the best in the nation in limiting explosive plays, and with their front seven once again disrupting Retzlaff’s timing, it’s tough to see him throwing for over 185.5 passing yards. The Rebels are 11th in the nation in EPA per pass surrendered, so expect to see their havoc-creating front dominate this football game.

Lacy has been a beast this season as the Rebels’ bellcow back. He’s averaged five yards per carry while rushing for 1,279 yards and 20 touchdowns, and exploded for 367 yards and four touchdowns in his last two games against SEC rivals Florida and Mississippi State.

Ole Miss gashed Tulane for 241 rushing yards in September, with Lacy scoring twice, and I’m betting on more of the same in the CFP rematch.

Mississippi kicker Lucas Carneiro has exceeded 7.5 kicking points in four of his last five games while averaging 10.2 kicking points a night.

With a high total of 57.5 and the Rebels’ team total of 37.5, Carneiro will be involved early and often in this one. With Ole Miss set to score points for fun today, Carneiro will breeze past this prop line.

Tulane vs Ole Miss Odds

TeamSpreadMoneylineTotal
Tulane+17.5 (-118)+640Over 57.5 (-110)
Ole Miss-17.5 (-104)-950Under 57.5 (-110)

Ole Miss are 17.5-point favorites in the college football odds. The Tulane vs Ole Miss total is set at 57.5 with both the over and under at an even -110.

The public loves the Rebels in this one, as 63% of against-the-spread bets and 94% of moneyline plays are on Ole Miss in the college football public betting splits.

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Odds as of December 20th at FanDuel. Look for the best college football betting apps for Tulane vs Ole Miss.

Nick Holz
Nick Holz

Sports Content Writer

A sports betting aficionado and graduate of Toronto Film School, Nick covers the NFL, NBA, Soccer, and MMA for SBD. He is also an avid NBA podcaster, and sports betting TikToker. Nick's work has been featured on Bleacher Report.

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