Padres vs Giants Odds, Picks, and Probable Pitchers (Sep. 15)

• The San Diego Padres are -115 favorites over the San Francisco Giants on Wednesday (September 15th, 9:45 pm ET)
• San Diego will give the ball to Joe Musgrove (10-9, 2.93 ERA), while it will be a bullpen game for San Francisco
• Read below for odds, analysis and a betting prediction

The San Francisco Giants can’t stop winning. It doesn’t matter who’s starting for them, or who’s pitching against them, they just keep getting the job done. Even after becoming the first team to clinch a playoff spot, they’re showing no signs of letting up on the gas.

Gabe Kapler’s crew will take a nine-game winning streak into action on Wednesday (September 15th) versus San Diego, looking to hand the Padres their sixth straight loss.

Padres vs Giants Odds

Odds as of  September 15th at DraftKings.

First pitch is scheduled for 9:45 pm ET at Oracle Park in San Francisco, with clear skies and 56 degree night time temperatures in the forecast.

Despite their incredible run, the Giants opened as a slight home underdog, in a game that features a total of 8.5. The main reason San Fran is not favored, is because for the second time in three nights they’ll throw a bullpen game. That shouldn’t discourage Giants backers however, as no bullpen in baseball has a lower ERA than San Francisco’s.

Probable Pitchers

Just like on Monday, Dominic Leone will get the ball first for the Giants. Two nights ago, he shutout San Diego over the opening two innings of the game, scattering just a single hit.

Dominic Leone as the bullpen game "starter" this month: 5 innings, 1 hit, 0 runs, 3 strikeouts. pic.twitter.com/wvw8QMypa8

— Alex Pavlovic (@PavlovicNBCS) September 14, 2021

Leone has excelled in this role with starters Alex Wood and Johnny Cueto on the injured list. He’s yet to surrender an earned run in his three “starts” holding the opposition to only two hits. San Francisco has gone on to win each of those contests, by a combined score of 21-6, while Leone hasn’t given up a run in his past six appearances overall.

Musgrove vs Giants Bullpen

The Padres bats enter play on Wednesday ice cold, having scored only six runs during their five-game skid. They’ve been outscored 15-2 in the first two games of this series and are hitting .169 over the past 7 days, with a minuscule .243 slugging percentage.

Joe Musgrove will counter for San Diego, fresh off taking the loss in a 3-0 defeat to the LA Dodgers. The right-hander surrendered four hits and all three runs over 6 innings, striking out seven and walking five. He’s give up three or fewer runs in four straight starts, and eight of his past nine outings, but has a miserable track record against San Francisco this season.

CSW% leaders since August 10th (minimum 20 IP):

1. Aaron Ashby 36.1%
2. Corbin Burnes 34.9%
3. Logan Webb 34.1%
4. Joe Musgrove 33.8%
5. Aaron Nola 32.8%

— Nolan Bratt (@BrewersFarm) September 13, 2021

In two starts versus the Giants, he’s coughed up 12 hits and 10 runs over 10 innings. San Diego has lost those games by a combined score of 14-2, while multiple San Fran hitters have tore the cover off the ball against him.

Batting Average vs Starting Pitchers

Brandon Belt, Tommy La Stella, Brandon Crawford, Steven Duggar and Curt Casali are all batting .429 or better versus Musgrove in a minimum of five at-bats.

Padres vs Giants Pick

The Giants have scored at least six runs in nine straight contests for the first time since 1958. The way they’re swinging, combined with how effective their relievers have been in bullpen games, makes them an auto-play at -105 odds. Of course it helps that the Padres are in a free fall and that San Diego’s bats are ice cold.

On Cloud W9#SFGiants | #ResilientSF pic.twitter.com/zQZSEYTvA5

— SFGiants (@SFGiants) September 15, 2021

Musgrove on the mound should improve the Padres winning prospects, but there’s no reason to fade San Fran given how much success they’ve had against the San Diego righty.

Pick: San Francisco Giants Moneyline (-105)