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White Sox vs Guardians Predictions, Odds & Player Props to Target (May 22)

Chris Amberley

by Chris Amberley in MLB Baseball

Updated Jul 4, 2023 · 12:56 PM PDT

Luis Robert scores versus the Guardians
May 16, 2023; Chicago, Illinois, USA; Chicago White Sox center fielder Luis Robert Jr. (88) scores against the Cleveland Guardians during the fifth inning at Guaranteed Rate Field. Mandatory Credit: Matt Marton-USA TODAY Sports
  • Cleveland is a -125 moneyline favorite in the White Sox vs Guardians odds on Monday
  • Chicago has won five of six, while Cleveland has dropped three straight
  • Keep reading for the White Sox vs Guardians predictions, probable pitchers and player prop picks

Two AL Central teams going in complete opposite directions clash on Monday in Cleveland. The hometown Guardians (20-26, 9-12 home) host the White Sox (19-29, 7-16 away), looking to snap a three-game losing streak.

Cleveland and Chicago met just last week for a three-game set, with the White Sox outscoring the Guardians 16-8 en route to taking two of three.

Online sportsbooks aren’t expecting a similar outcome in Monday’s MLB odds, as they opened Cleveland as the chalk for this divisional matchup.

White Sox vs Guardians Odds

Team Moneyline Runline Total
Chicago White Sox +105 +1.5 (-175) O 9 (-105)
Cleveland Guardians -125 -1.5 (+150) U 9 (-115)

Cleveland is currently a -125 moneyline favorite, in a contest with a total of 9. First pitch is scheduled for 6:10 pm ET at Progressive Field in Cleveland, OH, with clear skies and 73 degree temperatures on deck.



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Chicago vs Cleveland Probable Pitchers

After surprising the baseball world and making the playoffs in 2022, the Guardians have one of the 13th longest price tags in the World Series odds this year.

Their starting rotation is not to blame for their underwhelming play, but injuries to multiple starting pitchers is forcing them to turn to Hunter Gaddis on Monday.

That must be music to the ears of the White Sox regulars in the MLB starting lineups, as Gaddis has struggled mightily in limited Big League action. The 25-year-old owns a career 10.00 ERA and 1.70 WHIP, coughing up eight home runs in just 27 innings of work.

Gaddis allowed 16 hits and 11 runs over his last 10 innings prior to being demoted to the Minors, but the Guardians are desperate for an arm on Monday night to eat some innings. Cleveland recalled him on Sunday from Triple-A Columbus, and he’ll be looking for some revenge against Chicago.

The White Sox absolutely torched him in their lone meeting last season, teeing off for eight hits and five homers over just 4 innings.

As for Chicago’s starter, that position has yet to be named as of Monday morning. Former Guardians pitcher Mike Clevinger was put on IR on Sunday, leaving the White Sox down a starter.

Regardless of who gets the ball for Chicago however, they should be set up for success against one of baseball’s most underachieving lineups.

White Sox vs Guardians Predictions

Only two teams average fewer runs than Cleveland so far this season, while the Guardians also rank bottom three in hits, slugging and OPS, and dead last in home runs. They’ve cranked just 26 dingers all season, which is 64 fewer than the Rays and 24 less than the White Sox.

Cleveland has been held to three runs or less in four of their last six games overall, and mustered only three hits and a run on Sunday in a 2-1 loss to the Mets. They’ve dropped 13 of 20 overall, and have already been shutout five times this season.

White Sox vs Guardians 2023 H2H Results

Date Away Team Home Team Result
May 18 Guardians White Sox CLE, 3-1
May 17 Guardians White Sox CHW, 7-2
May 16 Guardians White Sox CHW, 8-3

Chicago meanwhile, is certainly no offensive juggernaut, but they have performed much better at the dish recently. Over the last seven days they’re slashing .271/.311/.447, while averaging nearly five runs a contest.

Luis Robert clubbed his 13th home run of the season on Sunday, while Andrew Benintendi has hit safely in seven straight. Benintendi was 5-for-12 last week versus Cleveland, while Jake Burger hit .500 versus the Guardians over the three-game set. Expect both of them to find success versus Gattis.

As for a prediction on the game, consider playing the under. Yes, Gattis is likely to struggle, but once he exits the game Cleveland’s bullpen should be able to limit the damage. Guardians relievers own the sixth lowest ERA in MLB, while only San Diego has seen a higher percentage of its games go under the total than Cleveland.

Unders are especially prevalent in Guardians home games, as 14 of their 20 contests at Progressive Field have come in below the total.


  • Under 9 (-115)
  • Andrew Benintendi 2+ Hits (+165)
  • Jake Burger 1+ Hit (-185)



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