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Cincinnati Bengals vs San Francisco 49ers Prediction, Odds, Best Bets NFL Week 8

Robert Duff

by Robert Duff in NFL Football

Updated Oct 28, 2023 · 12:30 PM PDT

The status of San Francisco QB1 Brock Purdy is impacting the Bengals vs 49ers odds.
Oct 23, 2023; Minneapolis, Minnesota, USA; San Francisco 49ers quarterback Brock Purdy (13) scrambles against the Minnesota Vikings in the first quarter at U.S. Bank Stadium. Mandatory Credit: Brad Rempel-USA TODAY Sports
  • The San Francisco 49ers are 4-point home favorites over the Cincinnati Bengals in their NFL game on Sunday, October 29
  • This betting line has shortened from 49ers -4.5 since word came that San Francisco QB1 Brock Purdy was in NFL concussion protocol
  • Cincinnati is 9-2 ATS as an away underdog since the start of the 2021 season. Are they are good bet in your Bengals vs 49ers picks on Sunday?

As they prepare to face the Cincinnati Bengals (3-3, 2-3-1 ATS), it’s hard to believe that a year ago, San Francisco 49ers (5-2, 4-3 ATS) QB1 Brock Purdy was best known as Mr Irrelevant. That’s the title given to the last player chosen in an NFL Draft, which Purdy was in 2022. Today, though, his relevancy is dramatically impacting the betting line for this game in the Bengals vs 49ers odds.

The Niners opened as 4.5-point home favorites in the Bengals vs 49ers odds. Since word got out that 49ers QB1 Purdy was in NFL concussion protocol, that line has shortened to San Francisco -4.

Looking more deeply into this game, let’s break down the Bengals vs 49ers picks and offer you our prediction for this NFL Week 8 contest.

Bengals vs 49ers Odds

Team Moneyline Spread Total
Cincinnati Bengals +170 +4 (-110) Over 43.5 (-110)
San Francisco 49ers -208 -4 (-110) Under 43.5 (-110)

In the Cincinnati vs San Francisco odds, the 49ers are -208 moneyline favorites, giving them a 67.53% implied win probability. The total is set at 43.5 points. Every San Francisco game this season has featured a total of 45 points or less.

Odds as of October 27 at BetMGM. Be sure to claim one of the best NFL betting promos to bet the Bengals vs 49ers picks in Week 8 NFL action.

The 49ers are 5-1 straight up in the past six meetings with the Bengals. Cincinnati is 1-4-1 against the spread in the last six games against San Francisco.

Kickoff for this game at Levi’s Stadium on Sunday, October 29, is set for 4:25pm ET. The broadcast is being carried by CBS and by DAZN in Canada.

Cincinnati vs San Francisco Betting Trends

In the NFL public betting splits, the Bengals have proven to be a solid play as a road underdog the past few seasons. Since the kickoff of the 2021 NFL campaign, Cincinnati is 9-2 ATS as an away underdog. It’s the second-best winning percentage (81.8%) in the league over that span.

The total has gone under in six of Cincinnati’s last eight games and five of the Bengals last six road games. Four of the past five Bengals vs 49ers games have also gone under.

San Francisco is the second betting choice in the Super Bowl 58 odds at +550. The Bengals are set with a betting line of +2200 in this market.

Bengals Back On Track

The Bengals once were where the 49ers are right now. At the outset of the season, Bengals QB1 Joe Burrow was nursing a calf injury and Cincinnati opened 0-2 SU. In the past two games, the 49ers are 0-2 SU and now Purdy is ailing.

The Bengals are coming into this game off their bye week and Burrow appears to be all the way back in terms of his health. Cincinnati is 3-1 SU over the past four games.

The defense has allowed more than 16 points in just one of the those three victories. Meanwhile, Burrow’s passer rating for the last two games was 108 and 88, much closer to his career average of 97.7. For the season, though, his passer rating is 79.8.

Purdy Latest Key Injury for 49ers

Already without WR Deebo Samuel (shoulder) and with the status of LT Trent Williams (ankle) uncertain, the 49ers can ill-afford to take the field without Purdy. It would be journeyman veteran Sam Darnold who’d be under center if Purdy can’t go.

Purdy did practice on Thursday and 49ers head coach Kyle Shanahan is confident that his QB1 will be playing on Sunday. He is reportedly 80% through the NFL concussion protocol.

Purdy threw two picks in San Francisco’s Week 7 MNF loss to Minnesota. The second came with 30 seconds to play in regulation, when it appeared as if the 49ers were driving for the winning score.

Cincinnati vs San Francisco Prediction

The Bengals are looking more like the team that’s been to the AFC Championship Game the past two seasons. Meanwhile, San Francisco has lost two in a row for the first time with Purdy as QB1.

Both of these teams are among the NFL elite. San Francisco is 17-3 SU over the past 20 games and 13-5 ATS through the last 18 games. Cincinnati is 13-4 SU in the last 17 games.

The Bengals are getting four points and considering San Francisco’s injury situation, taking those four points seems like the wise move.

Bengals vs 49ers Picks: Cincinnati Bengals +4 (-110)

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