Free Week 1 NFL Picks – Best NFL Parlay for Sunday Comes with +23441 Odds

• There are thousands of betting markets available for the first NFL Sunday of the 2025-26 season
• I have looked into all betting markets and surfaced up my favorite NFL picks for today
• See the four picks I am parlaying for +23441 odds below

The first NFL Sunday of the season is finally here, and that means our first great opportunity for an NFL parlay. The first one always excites me a little more – it’s something we haven’t had in so long, and the sportsbooks are also a little less sharp not having seen these teams play yet.

Looking across the 13 games being played today, and the thousands of betting markets available, I have put forth my favorite four NFL picks, which I am parlaying for +23441 odds. See my NFL parlay picks below!

NFL Parlay Picks

I am going to be taking advantage of DraftKings’ Ghost Leg Parlay bonus in Week 1, using it on this four-leg, +23441 NFL parlay. However, the best sportsbook for this parlay is actually bet365, where you can get +38107 odds if you’re willing to play Harvey at 30+ receiving yards. (I am still happy with that milestone.)

To be clear, not only am I parlaying these four picks, but I’m also playing them each as singles. You can get my justification for each of the four picks below!

In the five games David Njoku played with Joe Flacco in 2023, he averaged six receptions for 78 yards on nine targets per game. The tight end surpassed 90 yards in three of the games, and 100 in two of them. The two will look to re-establish that connection against a Bengals defense that ranked 21st against the pass, and allowed the fourth-most yards to tight ends, last season. With the Browns expected to find themselves playing from behind in this one, against what’s expected to be one of the league’s best offenses, I like Njoku to have a big game, surpassing at least 80+ receiving yards.

Emeka Egbuka has a great opportunity to make a big splash early in his rookie season, as Jalen McMillan is out for the season and Chris Godwin is expected to miss at least the first few weeks. The Bucs ranked third in passing yards last season, and were hoping for some continuity in the offense when they promoted passing game coordinator Josh Grizzard to Offensive Coordinator after Liam Cohen left. I think we’ll see a similar style of offense in Tampa Bay this season, and Egbuka is going to be a key piece of the air attack all season, but especially so as long as Godwin is sidelined. I think 80+ is very achievable for Egbuka against a Falcons defense that ranked 22nd against the pass last season.

Last season, Broncos running backs combined to haul in 83 receptions for 460 yards. That’s a per game average of 4.9 receptions and 27 yards. Sean Payton drafted RJ Harvey in the second round, much earlier than most draft experts believed he would go, because he has the burst and big-play potential he loves out of his running backs. While I appreciate JK Dobbins is technically listed as Denver’s starting running back for Week 1, I am very confident the interest Payton showed in putting the ball in Harvey’s hands during the preseason will continue into the regular season. Harvey doesn’t even need to take all the volume to surpass 25+ receiving yards – a couple opportunities will likely be plenty.

Jauan Jennings played one game last season without Brandon Aiyuk or Deebo Samuel in the lineup. He caught 11 balls on 12 targets for 175 yards and three touchdowns in that game. Jennings will see that same scenario in Week 1, with Samuel now a Commander and Aiyuk starting the season on the PUP. His only competition for targets will be George Kittle and Ricky Pearsall. It’s also worth noting that Jennings posted 91 yards on ten receptions the last time he played the Seahawks. I like Jennings to hit 80+ again versus the Seahawks today.