Detroit Lions vs Baltimore Ravens Picks & Closing Odds for Monday Night Football

• The Baltimore Ravens are 4.5-point home favorites vs the Detroit Lions on Monday Night Football
• Lamar Jackson has lost just twice in 26 matchups vs NFC teams
• Keep reading for my Lions vs Ravens picks and predictions, plus the DET vs BAL closing odds

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They are two of the NFL’s heavy hitters, so while it’s early, it’s not out of the question to call the Detroit Lions (1-1, 1-1-0 ATS) vs the Baltimore Ravens (1-1, 1-1-0 ATS) a potential Super Bowl preview.

Both teams are coming off spectacular Week 2 performances, but the books are favoring the hometown Ravens in the NFL odds.

Kickoff is scheduled for 8:15pm ET from M&T Bank Stadium in Baltimore, MD, with ABC carrying the broadcast.

DET Lions vs BAL Ravens Closing Odds

There was noticeable movement on the spread, with the Lions as distant as 6-point underdogs prior to their Week 2 kickoff against the Chicago Bears.

After Detroit’s offense went berserk, hammering Chicago 52-21, the line has been closing, to where it sits comfortably at 4.5 points.

Baltimore’s ability to score a ton of points is likely the reason it’s stayed outside of a field-goal range spread, as the Ravens have sliced up both the Bills and Browns, averaging 40.5 points through two games.

Significant to note the total has also found its way to 53.5 points, after starting at 50 flat, again prior to the Lions showing their offense is still intact without offensive coordinator Ben Johnson.

Odds as of 5:45 pm ET, Sept. 22. New customers can claim the BetMGM promo code and get a bonus to bet on MNF.

As for the NFL public betting percentages, Baltimore is taking in 90% of the bets on the moneyline, with a sizeable 68% of the money. The spread also skews Ravens, with 64% of the bets taking the B-More to cover, though the money is nearer to even at 54%.

Perhaps surprisingly, the Under is getting most of the bets at 81%, (on a 54.5 scoring line) but only 30% of the money. The 19% taking the Over are betting it big, with 70% of the money on the Over.

*The interactive table above will automatically update as the NFL betting odds move over the course of the day.

DET vs BAL Betting Trends

With two of the NFL’s dominant teams in recent years, there are clashing trends going head-to-head here.

Lamar Jackson eats NFC teams for breakfast, lunch and dinner, running a nearly perfect 24-2 record in 26 career games. He’s only lost to NFC East teams: the Giants in 2022 and the Eagles last year (who went on the win the Super Bowl).

The Lions, meanwhile, have looked superb on the road, going 14-4 against the spread since 2023.

They’ve also covered 13 straight road games following a home win.

Something will have to give though: Baltimore is 3-0 ATS as a home favorite and 5-1 in their last six as the favorite.

Who covers the spread tonight? 🤔

The Lions or the Ravens? pic.twitter.com/wQAF4RbY9F

— SportsBettingDime (@SBD) September 22, 2025

Lions vs Ravens Picks & Prediction

• Over 53.5 points (-110 at bet365)

I can’t shake the fact that these two teams, who rank inside the top six of the latest Super Bowl 60 odds, are literally the NFL’s most-potent offenses.

Detroit and Baltimore rank 1-2 in both scoring offense and total offense over the past three seasons.

While there is talent at every corner of the depth chart, each team’s success is centered at the pivot position.

Since two-time MVP Lamar Jackson was drafted in 2018, Baltimore is putting up better than 27 points and nearly 380 yards per game – which are both second overall in the NFL in that span.

GOFF TO JAMO FOR 44-YARD TD.

CHIvsDET on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/lkhS6bSOMo

— NFL (@NFL) September 14, 2025

Jared Goff got to Detroit in 2021, and he’s had the Lions humming at 26.7 points and 376.8 yards per contest.

Goff’s road-home splits the past two years are noticeable, and have been magnified through two weeks this season, but Baltimore’s defense is not the same one that stuffed them 38-6 in 2023.

It’s early, but the Ravens are allowing 298 pass yards per game and 29 points per contest.

MVP-caliber players like Lamar Jackson find ways to win football games, and he did just that against the Cleveland Browns with some crazy highlights!

Chalk up another loss for the guys who think making Lamar throw is the key to beating the Ravens! It's just not a good game plan! pic.twitter.com/AHgxm2Y3BO

— Nic Mason (@British_Raven19) September 16, 2025

On the other side, Baltimore is probably the hardest team to gameplan for: commit to stopping Derrick Henry, and Jackson can pick apart a secondary. He’s also more than capable or propping up the run game with some RPO keepers.

Limit the passing game, and it’s virtual death leaving Henry with gaps to get to the second level. Try to be effective at both? Lamar can dissect what defenses are doing at the line and act accordingly.

Detroit’s defense can only go up after last year’s injury-riddled campaign, but the Lions are going to need to put up points to keep up in this track meet.