NFL Week 16 Odds – Opening Betting Lines & Spreads for All Games

• NFL Week 16 kicks off with an NFC clash between the New Orleans Saints and Los Angeles Rams in the TNF game
• There’s three games on Christmas Day, including a MNF showdown between two division leaders in the Baltimore Ravens (AFC North) and San Francisco 49ers (NFC West)
• A look at all the opening NFL Week 16 odds can be found below with early predictions

The NFL Week 16 schedule could see the Detroit Lions ending one of the longest droughts in the league. With a Christmas Eve victory at Minnesota over the Vikings, the NFC North-leading Lions would clinch their first division title since 1993.

Among three Christmas Day games is a potential Super Bowl preview on MNF, as the NFC West-leading San Francisco 49ers play host to the AFC North-leading Baltimore Ravens.

The Week 16 TNF game features a pair of 7-7 clubs, as the resurgent Los Angeles Rams tangle with the New Orleans Saints, who own a share of the NFC South lead.

Let’s take a look at all the opening betting lines for the NFL’s Week 16 slate.

Opening NFL Week 16 Odds

The NFL odds for Week 16 are showing the Buffalo Bills as the largest favorites. They are the 12-point away choice at the Los Angeles Chargers, who will be playing their first game since firing head coach Brandon Staley and GM Tom Telesco.

The Philadelphia Eagles and Kansas City Chiefs, last season’s Super Bowl teams, are both the 10-point home chalk in their Week 16 games against division rivals. Kansas City is the pick over the Las Vegas Raiders, while Philly is favored over the New York Giants.

Odds as of December 17 at DraftKings Sportsbook. 

Two games are tied for the lowest spread of Week 16. The Pittsburgh Steelers are 1-point home favorites against the Cincinnati Bengals, while the Atlanta Falcons are the 1-point home choice over the Indianapolis Colts.

The highest total is 51 points in Dallas vs Miami. This contest includes the NFL’s #1 (Dallas at 32.3 PPG) and #2 (Miami, 31.6 PPG) scoring offenses in the NFL. The smallest total is the 35.5 points assigned to the Green Bay Packers vs Carolina Panthers game. It’s the second time in as many weeks that the Panthers are included in what’s projected to be the lowest-scoring NFL game of the week.

The 49ers are favorites in the Super Bowl odds at +230.

Saints vs Rams Early Odds & Predictions

The Rams are looking like a juggernaut of late. They’ve gone 4-0 ATS in their last four games and hit the over in all four games.

.@Demarcus grabs it in the endzone!

📺 @NFLonCBS pic.twitter.com/CxyiA3Tm7A

— Los Angeles Rams (@RamsNFL) December 17, 2023

When the Saints covered on Sunday against the New York Giants, it was just the second time that’s happened over the club’s past six games. New Orleans is 2-4 ATS through the club’s past six road games.

Pick: Rams -3 (-115)

Opening Ravens vs 49ers Odds & Predictions

What a holiday gift the NFL is giving bettors by pitting the Ravens at the 49ers in a Christmas evening MNF tilt. These two teams already met once in the Super Bowl and it’s not a stretch to suggest it could happen again this season.

The Ravens are a solid 4-1 SU and 3-2 ATS on the road this season entering their Week 15 SNF game at Jacksonville. San Francisco is 5-1 SU at home, but just 3-3 ATS.

Pick: Ravens +4 (-110)

Expected Week 15 Line Movement

It’s going to fascinating watching the NFL public betting splits unfold on the Cowboys at Dolphins game. Miami is a dreadful 0-3 ATS this season when facing opponents with winning records.

FINAL: @MiamiDolphins get their 10th victory! #NYJvsMIA pic.twitter.com/81wl5o9pcq

— NFL (@NFL) December 17, 2023

However, the Cowboys are an unimpressive 3-4 ATS as a road team. But at least Dallas has shown some success in this scenario. Look for the people be backing the ‘boys.

Pick: Cowboys +1.5 (-110)