Opening NFL Week 6 Odds – Spread, Moneyline & Total for All Games

• The Week 6 NFL odds have been posted
• Another four teams (Chiefs, Dolphins, Rams, Vikings) are on bye in Week 6
• See the opening Week 6 NFL odds for all 14 games on the schedule

Another NFL Sunday is almost in the books, which means the lines for next week have been released.

The schedule starts with a huge NFC West game between the San Francisco 49ers and Seattle Seahawks and concludes with a battle between two desperate AFC East teams when the Buffalo Bills visit the New York Jets on Monday Night Football.

The table below lists the opening Week 6 NFL odds, including point spread, moneyline, and game total, for all 14 games on the slate.

Week 6 NFL Odds

Week 6 is another week characterized by narrow spreads: eight of the 14 games have an opening point spread of a field goal or lower. Only one is over a touchdown.

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Odds as of Oct. 6 at FanDuel and DraftKings. Download the top NFL betting apps ahead of Week 6. 

The Chiefs (+500) and 49ers (+650) remain the top-two favorites in the 2025 Super Bowl odds heading into Week 6. Now riding a three-game win streak after an 0-2 start, the Ravens sit alone in third at +800.

Biggest Week 6 Spread: Texans (-7.5) at Patriots

The biggest number on the board in the early Week 6 NFL odds is Houston laying 7.5 points on the road at New England. The Texans moved to 4-1 on the season with a last-second victory over the Bills (23-20) in Week 5. Surprisingly, though, that was their first ATS victory of the season. Their margin of victory in their four wins is just 15 points total (3.75 on average).

The Patriots fell to 1-4 SU and 1-3-1 ATS with a hugely disappointing 15-10 home loss to the floundering Dolphins in Week 5. They were badly out-gained (372 to 299) by a Tyler Huntley-led Miami offense.

Highest Week 6 Game Total: Lions vs Cowboys (52.0)

To no one’s surprise, the Detroit/Dallas game has opened with the highest Week 6 total at 52.0, half a point higher than Washington/Baltimore. The Cowboys’ defense has been one of the most-porous units in the NFL all year, and they’ll be missing their leader, Micah Parsons, on SNF in Week 5. It’s unclear whether he’ll be back in Week 6.

Detroit paired a high-octane offense with a susceptible defense in 2023, which led to them going 14-5 O/U. That dynamic seemed to have shifted early in 2024 as they hit the under in their first three games of the season, but a 42-29 shootout victory over Seattle in Week 4 played more into preseason expectations for Detroit.

Coming off a Week 5 bye, Detroit has opened as a three-point road favorite in Big D and oddsmakers are clearly expecting Jared Goff and company to have their way with a vulnerable Dallas defense.

Lowest Week 6 Game Total: Chargers vs Broncos (36.5)

The lowest total of the week is a tie between Chargers/Broncos and Steelers/Raiders, which both opened at 36.5. But the Chargers/Broncos odds favor the under at -115, so it gets the nod as lowest Week 6 game total.

The Broncos are coming off a high-scoring 34-18 home win over the Raiders but, prior to that, Denver games were averaging just 29.3 PPG.

The Chargers, whose length injury report in Week 4 included starters Joey Bosa, Ja’Sir Taylor, Joe Alt, and Rashawn Slater, are coming off a much-needed bye. At 2-2 on the season, LAC games are averaging just 29.5 PPG and none have gone over 32.

Keep an eye on the NFL public betting splits to see how the Week 6 lines shift in the coming days.