Week 2 NFL Picks: Best NFL Parlay for Sunday Features 4 Players Predicted to Have Big Games

The second NFL Sunday of the 2025-26 season is here, and features 13 games on the schedule. With so many games crammed into one day, it means there are thousands of betting markets made available by sports betting apps. I see it as the perfect time to take advantage of some markets sportsbooks aren’t paying as much attention to, and lock in an NFL parlay with a big potential payout.

I have spent my week going through every one of the thousands of NFL betting markets, and absolutely love these four Week 2 NFL picks, all of which are player props with alternate lines, that I am parlaying for +8395 odds. Below, I will provide my analysis and reasoning for each NFL pick, and where to find the best price for the full parlay, as well as each of them as singles.

NFL Parlay Picks for Week 2

The sportsbook where you can get the +8395 (best) odds on my best NFL parlay for Week 2 is bet365. You can either navigate into each matchup, then selecting the player props tab, or just navigate away from game lines and to the specific type of player prop to avoid to much back-and-forth.

Alternatively, you could take this longshot NFL parlay over to DraftKings and take advantage of their Ghost Leg Parlay bonus, where you’ll still win the parlay if only one leg loses – they will void that leg and price it out again. This parlay meets their requirements of at least three legs and max odds of +10,000. Your potential profit just will not be nearly as much as it is at bet365.

If you’re new to parlays or want to gain a better understanding of them, check out our guide on how parlays work.

Continue reading below to see my logic behind each pick, supported by all the pertinent stats and data to that specific NFL player prop.

🏈Leg 1: Travis Etienne 70+ Rushing Yards (+200)

The first leg of this longshot NFL parlay is Travis Etienne to rush for 70+ yards. Etienne wasted no time trying to prove last year was an anomaly, not the beginning of the end to his career. The former first-round pick rushed for 143 yards, averaging 8.9 yards per rush, and added three receptions for 13 yards against the Panthers in Week 1.

I was encouraged to see Etienne play 60.6% of Jacksonville’s offensive snaps, and he handled 64% of the carries that went to running backs. While I don’t know the full reason Tank Bigsby was traded to the Eagles after this game, it’s at least safe to assume Liam Cohen saw enough from Etienne in Week 1 that he was confident to move forward with him as the true lead back. It’s very reasonable to think Etienne might see more than 19 touches in Week 2.

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You could say his big Week 1 performance was just a matter of playing the Panthers, which may be true. But I don’t think the Bengals defense is much better.

The Bengals did hold the Browns to just 49 yards on the ground in Week 1, at an average of just over two yards per carry. However, the Browns offensive line was brutal at run blocking last season, and they have been forced to replace Jedrick Wills at LT with Dawand Jones – he had a horrific Week 1. So, I’m not putting much stock into that defensive performance.

I did take notice of Cincinnati’s 12.5% missed tackle percentage, though.

I like Cohen to lean on Etienne again in Week 2, with hopes of controlling the clock a bit and keeping Joe Burrow and Ja’Marr Chase on the sideline for extended periods.

If you’re looking to bet this as a single, the best odds are +200 found at bet365. If you’re not already signed up with them, be sure to check out our bet365 bonus code before registering.

🏈Leg 2: Hunter Henry 50+ Receiving Yards (+190)

Next up in my NFL Week 2 picks is Hunter Henry to record 50+ receiving yards. Henry was tied for the team-high with eight targets in Week 1, but only managed to bring in four of them – he was not charged with any drops, though.

What is even more eye-catching is the fact that Henry ranks 8th in the NFL in targeted air yards per game with 116, just six yards behind Malik Nabers. Also, among all Patriots’ pass-catchers, Henry played the highest percentage of snaps (93%), whereas his backup, Austin Hooper, only played 32%. The usage metrics are all there!

The production is also typically there when Drake Maye plays too. When Henry and Maye both start and play more than 60% of the snaps, the tight end averages 57.2 receiving yards on eight targets per game. He has gone over 50 receiving yards in five of those nine games.

Henry and the Patriots will take on a Dolphins defense in Week 2 that just allowed Tyler Warren to go off for 76 yards on seven receptions in his first NFL game. In total, they allowed Daniel Jones to throw for 272 yards, completing 22 of 29 pass attempts. The game was so out of hand that Jones only threw one pass in the entire fourth quarter.

There are still some concerns of precipitation in Miami, but it doesn’t appear to be anything that would prevent the Patriots from throwing the football. So, I like Henry to continue seeing good volume in the passing game, and take advantage of a demoralized, and simply bad, Dolphins defense.

Once again, bet365 has the best odds for this alternate line. If you’re looking to bet it as a single as well, you can get +190 odds at bet365.

🏈Leg 3: Javonte Williams 70+ Rushing Yards (+210)

The third leg of my best NFL parlay for Week 2 is Javonte Williams to rush for 70+ yards. I discussed liking Williams this week in my Week 2 NFL TD picks, so I’ll try not to be too repetitive here.

Williams accounted for 68.2% of Dallas’ rushing attempts and played 77% of their offensive snaps in Week 1. That share equaled 15 rushes for 54 yards and two touchdowns against an Eagles defense that is still tough against the run without Jalen Carter.

But Williams won’t be seeing a stingy defense in Week 2, as the Cowboys take on the Giants. New York just allowed 220 rushing yards to the Commanders, on 6.9 yards per carry. I’m not suggesting Dallas will average the same YPC, as Jayden Daniels certainly helps hold up opposing linebackers in a way Dak Prescott never could, but I don’t think they will need to for Williams to get 70+ yards.

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Dallas is laying 5.5 points at home and have had a couple extra days to rest and prepare for this one. I believe Williams will operate as the lead back again, and has a good opportunity for even more volume. Not only is it fair to expect Dallas to play a bit of this game with a positive game script, but I think they’ll also get to run more than 56 plays in Week 2.

The Eagles play slow – averaged 7.8 plays and 4:21 time of possession per drive last week – and I don’t believe the Giants are capable of holding the ball too long with Russell Wilson under center. The G-Men did run 6.9 plays per drive last week, but only averaged 3:23 time of possession per drive, while only converting 25% of their third downs.

I like the ball to be in Dallas’ possession often in Week 2.

The best odds you can find on this bet are +210 and, once again, are available at bet365.

🏈Leg 4: Trey Benson 50+ Rushing Yards (+215)

I wrap up my Week 2 NFL picks with Trey Benson to rush for 50+ yards. To be clear, I do not think Benson is all of a sudden going to be the guy in Arizona because he greatly outperformed James Conner one week. I don’t think Benson needs to be the lead back to surpass this total against Carolina, though.

The Cardinals are currently 6.5-point favorites over the Panthers in Week 2. I like them to easily cover this spread – I don’t think Bryce Young is going to look much better than what we saw against Jacksonville last week, and their defense is pretty lousy. I discussed Travis Etienne carving them up last week to the tune of 8.9 yards per carry.

Every Trey Benson touch from Week 1 pic.twitter.com/pqrIWuMzOm

— Jacob Gibbs (@jagibbs_23) September 11, 2025

I think Arizona is going to be playing with a very positive game script early in this one, which may result in an even better split for Benson than he saw last week. The second-year back only handled 29.6% of the team’s rushes in Week 1 (on 33.3% of the snaps), which is much better than the 13.6% he saw last year, but he did account for 47.3% of their rushing yards. This is largely the result of him ripping off a 52-yard gain early in the third quarter.

But even if the Cardinals find themselves struggling to pull away, they’re still going to run the ball. Drew Petzing’s offense ran the ball on 44.3% of their snaps in Week 1, which is almost identical to their splits the previous two seasons of Petzing calling their plays. I also think Benson’s big-play potential is going to be more and more difficult to keep on the sideline, especially with a back like Conner as the leader of the backfield.

You guessed it: bet365 has the best odds here at +215.