Week 5 NFL Picks: Best NFL Parlay Includes 4 Player Props to Bet & 55-1 Odds

Published: October 5, 2025 at 9:00 am EDT

Quentin Johnston signaling a first down — Sep 21, 2025; Inglewood, California, USA; Los Angeles Chargers wide receiver Quentin Johnston (1) reacts after a play during the second half against the Denver Broncos at SoFi Stadium. Mandatory Credit: William Navarro-Imagn Images

Sunday of NFL Week 5 is upon us and features 12 games across three different time blocks. With so many games in one day, I like to put together an NFL parlay spanned across a handful of games. As usual, I have honed in on four players who I think will really outperform expectations set by their player props, and am parlaying them for a potential big payout, while also betting them as singles.

I spent the latter half of my week analyzing all the NFL betting markets for Week 5, doing extensive research on usage stats, and digging in to find the most favorable matchups we’ll see today. The result was the below four-leg NFL parlay that comes with +5562 odds. I’ll provide my data-rooted justification for each pick under the table.

NFL Parlay Picks for Week 5

Player	Prop Pick	Odds
Woody Marks	100+ Rushing & Receiving Yards	+250
JK Dobbins	60+ Rushing Yards	+155
Quentin Johnston	70+ Receiving Yards	+135
Alvin Kamara	70+ Rushing Yards	+170
Total Parlay Odds		+5562

I believe sportsbooks are really underselling these four players in Week 5. But I’m not just betting their standard over/under. I’m taking alternate lines, or milestones if you prefer, to increase the potential payout. Each one of these player props are best wagered at bet365, where you’ll find (by far) the best odds for each pick. As a result, bet365 is also the best option for my 4-leg NFL parlay with these picks, and it comes with +5562 odds.

If you’re wondering how my picks went last week, I was just 1-3. However, the one I did hit was for +220 odds, so I was only down 0.8 units for the picks, thankfully. Apparently the Steelers learned how to defend the run, and Quentin Johnston, not Keenan Allen, is Justin Herbert’s favorite target – or at least that’s the way it went last week.

If any of this is confusing to you, read our guide on how parlays work. It’s crucial to fully understand every bet you are placing in order to maximize success in sports betting.

As long as you’re still confidently following along, read on for my analysis and justification for each leg in my Week 5 NFL parlay.

🏈Woody Marks 100+ Rushing & Receiving Yards (+250)

I believe last week was Nick Chubb’s final game as the lead back in Houston. Though he still saw 13 carries, which ties his season-high, he was pretty inefficient with the work (3.6 YPC) and played a season-low 42.3% of the Texans’ offensive snaps. The low came because rookie Woody Marks broke out for 119 yards from scrimmage.

This was not just garbage time usage either. First of all, the Texans entered the fourth quarter of their matchup with the Titans only up 6-0. Second, 10 of Marks’ 21 touches came in the first half. It was Marks’ explosiveness that helped break the game open in the fourth quarter. The big game drew praise from DeMeco Ryans, who on Monday said, “we’re excited to see how much more he can handle,” referring to Marks.

Woody Marks Usage & Scrimmage Yards Stats

Week	Offensive Snap%	Looks (Carries + Targets)	Touches	Yards from Scrimmage
1	11.1%	3	3	3
2	26.5%	4	4	51
3	47.6%	8	7	36
4	56.3%	22	21	119

As you can see, the rookie’s snaps had been steadily increasing week-over-week, and he exploded when he was finally given the touches. I appreciate that Ryans has also remained supportive of Chubb, and believes the two complement each other well. However, this is a 1-3 Texans team that has been struggling mightily on offense, evident by their 16 points per game average (29th), and are in desperate need of a spark to climb back into the race for the AFC South.

Simply put, they don’t have the luxury of easing Marks into their game-plans. They need his speed and elusiveness to help mask their horrific offensive line, and Week 5 presents a great matchup for the rookie RB, as the Texans will take on the very injured Baltimore Ravens.

The Ravens defense hasn’t been very good this season, and they’ll be without Roquan Smith, Marlon Humphrey, and Chidobe Awuzie – Kyle Hamilton is also listed as questionable. Baltimore is allowing 6.8 yards per pass attempt (17th) and 4.59 yards per rushing attempt (23rd). I like Marks to find some room on the ground and also take some big chunks off screen plays designed for him.

The standard rushing and receiving yards over/under for the Texans’ rookie is somewhere between 77.5 and 79.5, depending on the sportsbook. If you’re hesitant to take the full 100+ milestone at bet365 for +250 odds, and want to go a little lighter, you can get 90+ rushing and receiving for Marks at ESPN Bet for +150 odds. Unfortunately, bet365’s rushing and receiving milestones go up by 25-yard increments.

That’s no concern for me, though, as I like Marks for 100+. If you’re not already signed up at bet365, you can register now to tail this pick!

🏈JK Dobbins 60+ Rushing Yards (+155)

JK Dobbins is averaging 80.8 rushing yards per game this season, and has surpassed 60 yards on the ground in all four games. While it is certainly likely that rookie RJ Harvey eventually eats into some of Dobbins’ work, the veteran has remained the clear lead back and just snapped the Broncos 37-game streak of not producing a 100-yard rusher.

Dobbins is averaging 14.3 rushing attempts per game, which is good for 50.4% of Denver’s carries – keep in mind that Bo Nix has recorded 25 rushing attempts this season; Harvey has only seen 27 carries. As the Broncos prepare for the Eagles in Week 5, I expect Dobbins to remain a firm part of their game plan.

Philadelphia’s defense has been very good against the pass, only allowing 6.3 yards per pass attempt (7th-fewest), but they haven’t been great against the run, allowing 4.8 yards per rushing attempt (7th-most). Here’s how their opponents’ lead backs have fared in their first four games:

Week	Running Back	Rushing Attempts	Rushing Yards
1	Javonte Williams (Cowboys)	15	54
2	Kareem Hunt (Chiefs)	8	31
3	Kyren Williams (Rams)	20	94
4	Bucky Irving (Bucs)	15	63

While only two of four teams have seen a running back go over 60 yards against the Eagles, it’s worth noting that Miles Sanders added 53 rushing yards against them in Week 1, Patrick Mahomes recorded 66 rushing yards in Week 2 (plus, the Chiefs haven’t run the ball efficiently all season), and Blake Corum totaled another 53 in Week 3.

I think Sean Payton will look to lean on Dobbins a fair bit on first and second downs in an attempt to keep his young QB in third-and-manageable situations. It may not be overly flashy, but I like Dobbins to go over 60 rushing yards with the 15+ carries I’m expecting him to see.

His over/under is just 49.5 at bet365, while other sportsbooks have him as high as 52.5. If you’re betting this as a single, be sure to do so at bet365, where you’ll get +155 odds. The next-best price was just +140 at FanDuel.

🏈Quentin Johnston 70+ Receiving Yards (+135)

Quentin Johnston has surpassed 70 receiving yards in all four games this season. Here’s a quick look at his stats in each of those games:

Week 1: 79 receiving yards
Week 2: 71 receiving yards
Week 3: 89 receiving yards
Week 4: 98 receiving yards

As I discussed in my Week 5 NFL TD predictions, Johnston is not just a deep-threat for the Chargers. He’s averaging 9 targets per game, which is ninth-most in the NFL, and has not dropped a pass yet this season. Johnston is 7th in the league when it comes to targeted air yards per game, averaging 114.5.

The Commanders defense the Chargers will face in Week 5 has been pretty good against the run, only allowing 3.64 yards per carry. However, they give up 8.6 yards per pass attempt, which is third-worst in the league. Neither Marshon Lattimore or Trey Amos, who expect to line up across from Johnston on the majority of snaps, have been very good this season.

After a bad loss to the Giants last week, I think LA comes out very aggressive on offense, specifically looking for their speedy wide receiver early and often.

Johnston’s receiving yards over/under is just 60.5 at bet365, which is why we’re getting great +135 odds on 70+ yards.

🏈Alvin Kamara 70+ Rushing Yards (+170)

Alvin Kamara has only reached 70+ rushing yards in two of four games this season and is averaging 64 rushing yards per game. However, Kamara is seeing some of the best usage of his career, averaging 16.3 rushing attempts per game, which is tied for the second-most in any season of his career.

What’s even more encouraging is that sportsbooks believe the Saints will not only keep this game competitive, but believe they’re going to win it, as they’re listed as 2.5-point favorites against the Giants at home. Kamara had been seeing this solid usage as the Saints were 14.5-point underdogs to the Bills, 6.5-point dogs to the Seahawks, and 2.5-point dogs to the 49ers. So, who knows how many times Kellen Moore will call his running back’s number in a tight game, or even if they have a lead.

What makes this such an attractive bet for me, though, is how bad the Giants defense is against the run. New York has allowed 6.06 yards per rushing attempt, the second-worst mark in the league, and have surrendered at least 105 rushing yards in every game. Here’s how their opponents’ top running back has performed against them each week:

Week 1: Jacory Croskey-Merritt rushes for 82 yards on just 10 carries
Week 2: Javonte Williams totals 97 rushing yards on 18 attempts
Week 3: Isiah Pacheco records a season-high 45 rushing yards on 10 attempts
Week 4: Omarion Hampton rushes for 128 yards on just 12 carries

Kellen Moore needs a win and his path to getting his first as a head coach is clear: let Alvin Kamara run all over the Giants.

I like Kamara to be a big part of the Saints’ Week 5 game plan and believe he will deliver with at least 70 rushing yards. His rushing over/under is just 56.5 at bet365, so I’m betting the 70+ milestone for +170 odds.

Matt McEwan

Editor-in-Chief; Sports Betting Expert

With nearly a decade working in the industry, Matt is a seasoned sports betting veteran. He got his start with SBD in 2016 and worked his way up the ladder to become the Editor-in-Chief. Along the way he has done everything from reviewing sportsbooks to creating proprietary sports betting tools.

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