Villanova vs Xavier Odds, Lines & Picks (Feb. 21)

By George Nassios in College Basketball
Updated: April 11, 2023 at 4:43 pm EDTPublished:

- The Villanova Wildcats pay a visit to the Xavier Musketeers on Tuesday, February 21st
- The Musketeers have been tremendous at home this season, sporting a 14-1 record as hosts
- Below, you can find all the Villanova vs Xavier odds, plus our best bet and prediction
After suffering back-to-back heartbreaking losses by a combined three points, the Xavier Musketeers (20-7, 15-11-1 ATS) got back in the win column on Saturday, with an 82-68 victory over DePaul.
On Tuesday, February 21st, Xavier are 5.5-point favorites against a Villanova Wildcats (13-14, 10-17 ATS) side who are struggling through their first losing season in more than a decade. Tipoff for this affair goes at 6:30 pm ET from the Cintas Center.
We’ve got all the Villanova vs Xavier odds for you to check out below. As well, our best bet and pick for this Big East affair will be offered up for you to consider.
Villanova vs Xavier Odds
Team | Spread | Moneyline | Total |
---|---|---|---|
Villanova Wildcats | +5.5 (-115) | +176 | O 147.5 (-106) |
Xavier Musketeers | -5.5 (-105) | -215 | U 147.5 (-114) |
Odds as of February 20th from FanDuel. Claim the current FanDuel promos.
Since conference play began, the Wildcats have seriously struggled on the road. They’re just 2-6 as visitors in league play and they’ll have their hands full when they drop in on an Xavier squad that own a 14-1 home mark this season.

Villanova Wildcats Swift Fall From Grace
Just last season, Villanova entered March Madness as the 6th ranked team in the entire country. They have been a perennial favorite in the odds to win the NCAA tournament for most of the last decade. Things have fallen apart this campaign.
Long time head coach Jay Wright retired and Villanova are in a dog fight just to qualify for the Big East tournament, never mind grab a spot in the big dance. Much was expected of freshman, Cam Whitmore, but the forward missed seven games earlier this year with an injury and is averaging just 12.1 points per game on the season.
March 7, 2012: last time Villanova basketball was under .500
Post Jay Wright era is officially here
— MattyMass (@MattyMass) November 24, 2022
Lack of buckets is something that’s been an issue for the squad as whole, not just the Wildcats rookie. Putting up just 69.5 points per game, the Wildcats are 227th in scoring in the nation. They’ve hit the under in the college basketball odds in six of their last eight games.
Xavier Musketeers Offense Is on Point
Sitting one game behind Marquette with just a couple weeks left to play, the Musketeers have an eye on taking the regular season title. The primary reason for their terrific season has been an outstanding offense that’s tops in the conference and 9th in the country with 82.6 points per game.
Since the beginning of the season, their odds to win March Madness have shortened tremendously from +8500 at the outset of the campaign, to their current odds of +4000.
2️⃣0️⃣ 𝘄𝗶𝗻𝘀 𝗮𝗻𝗱 𝗰𝗼𝘂𝗻𝘁𝗶𝗻𝗴…#LetsGoX pic.twitter.com/sTMOX4qJAL
— Xavier Basketball (@XavierMBB) February 18, 2023
They have absolutely been cooking at home, with their only loss as hosts coming back on November 18th when they lost 81-79 to Indiana. It’s been over a month since an opponent has kept them from putting up at least 80 at the Cintas Center. As such, they’re 11-3-1 hitting the over at home this season.
Villanova vs Xavier Prediction
In the two seasons prior to this one, Villanova swept the season series against Xavier. Undoubtedly, the Musketeers are looking forward to payback, having already defeated the Wildcats 88-80 in Philadelphia last month.
Villanova vs Xavier Recent Results
Date | Home-Away | Spread | Over/Under |
---|---|---|---|
01/07/2023 | VILL 80 – XAV 88 | XAV | Over |
01/12/2022 | XAV 60 – VILL 64 | VILL | Under |
12/21/2021 | VILL 71 – XAV 58 | VILL | Under |
02/22/2020 | XAV 55 – VILL 64 | VILL | Under |
12/30/2019 | VILL 68 – XAV 62 | VILL | Under |
To put it bluntly, taking Xavier to cover is a no-brainer here. They do have a number of players who will be out of action or playing while recovering from injuries, but other than forward Zach Freemantle, those are mostly role and bench players.
Our prediction is to take the gift that is being offered from the sportsbooks here and take the Musketeers to win by more than 5.5 points in the Villanova vs Xavier odds.
Pick: Xavier Musketeers -5.5 (-105)
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Sports Writer
George has had a lifelong love affair with sports and studying sports statistics since he was a kid. He graduated from Ryerson University with a Bachelor's Degree in Journalism and has worked in the sports & media industry ever since in various roles from writer to producer.