Drake vs Missouri Odds, Picks, Props & Betting Splits

• The 6th-seeded Missouri Tigers are 6.5-point favorites over the Drake Bulldogs in Round 1 NCAA Tournament play
• The Bulldogs have ripped off seven wins in a row
• See the Drake vs Missouri odds, player props, and predictions for March 20

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If the Missouri Tigers (22-11, 18-15-0 ATS) want to make some noise in the NCAA Tournament , they’ll first have to knock off the Drake Bulldogs (30-3, 17-14-0 ATS), the reigning Missouri Valley Conference Champion.

This matchup in the West Region tips off on Thursday at 7:35pm ET from INTRUST Bank Arena in Wichita, KS, with truTV providing the broadcast coverage.

Check below for the Drake vs Missouri odds, player props plus my betting prediction.

Drake vs Missouri Public Betting Splits

The March Madness public betting splits show the public likes the underdog. The Bulldogs are the clear choice for covering the spread, with 70% of the bets and 61% of the money on the #11 seed.

On the moneyline, only 22% of wagers are on Drake to win, but they account for 64% of moneyline handle.

The game-total betting splits heavily favor the over, with 92% of the bets and 92% of the money on the teams going over the total of 132.5.

Drake vs Missouri Odds

The Bulldogs enter as a 6.5-point underdog in Thursday’s college basketball odds, and a distant +210 on the moneyline. The total comes in at 132.5 points.

Odds as of March 20 at DraftKings. Read SBD’s guide to the March Madness betting strategy.

Missouri staggers into March Madness with five losses in its last seven games, including a 95-81 beating at the hand of the Florida Gators in the quarters of the SEC Tournament.

Asked #Mizzou standout Mark Mitchell how his knee is doing.
He good 👍👍👍👍 pic.twitter.com/KhMfjF2mwC

— Nathalie Jones (@NathalieABC17) March 19, 2025

The Tigers are one of 14 teams representing the SEC in the Tournament, but they could be less than 100% if leading scorer Mark Mitchell (knee) is compromised. All indications currently point to him playing.

The Bulldogs are coming off a 63-48 win over Bradley in the MVC Tournament final.

Drake enters March Madness on a roll, taking just a single loss over the final 19 games of the season.

Drake vs Missouri Prediction

The Bulldogs are not the kind of team you want to be facing in the NCAA Tournament, let alone when you are struggling.

Drake brings the nation’s top scoring defense, allowing teams to score just 58.4 points per game. They have allowed only two teams crack the 60-point plateau over the last seven games.

If there is a knock on a 30-win conference champion, it’s strength of schedule. Drake did not play a ranked team this season, and sit in 160th in KenPom’s SOS metric.

They also haven’t played sine March 9, and an 11-day layoff between games can hamper any team’s return to live game action.

Even with their recent struggles, Missouri is a stats darling, ranking 15th in KenPom’s overall ranking, powered by a Top 5 offensive rating.

The Tigers are the ninth highest-scoring team in the nation, pumping out 84.5 points per game. They haven’t been able to outscore their problems of late though, hence the end-of-season struggles.

Mizzou allows 73.8 points per game, which ranks 11th in the SEC, but over their last five games, they have allowed 91 points or more on four different occasions, all resulting in losses.

Drake’s scoring offense ranked 10th in the Missouri Valley, averaging 70.8 points per contest, hitting 71 points just one during their current win streak.

I see this one as having major upset potential. While Missouri should advance, Drake puts a real scare into them in Round 1.

• Drake vs Missouri: Drake +6.5 (-112)

Mizzou vs Drake Player Props

Drake vs Missouri player props from bet365 on Mar 20. Claim the current bet365 bonus code to get a bonus for Thursday’s NCAAM slate.

MVC Player of the Year Bennett Stirtz has the highest scoring prop of any player on the floor at 17.5 points.

The junior guard is coming off a 24-point gem in the conference touranment final over Bradley. Stirtz has gone for 18 or more points in 12 of his last 15 games on the season.

Mithell has the highest scoring total for the Tigers at 13.5 points – just a touch under his 14.1 point average on the season.