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Week 9 College Football Odds, Lines & Predictions 2025

Sascha Paruk

By Sascha Paruk in College Football

Published:


Texas A&M Aggies quarterback Marcel Reed running with the football
Oct 18, 2025; Fayetteville, Arkansas, USA; Texas A&M Aggies quarterback Marcel Reed (10) rushes for a touchdown that was called back for holding during the fourth quarter against the Arkansas Razorbacks at Donald W. Reynolds Razorback Stadium. Mandatory Credit: Nelson Chenault-Imagn Images
  • College football Week 9 odds are posted at online sportsbooks
  • Nine top-25 teams lost last week, creating upheaval in the rankings and the Week 9 spreads
  • See the opening NCAAF Week 9 odds for all power-conference and top-25 games

After a wild Week 8, sportsbooks have posted college football Week 9 odds for the vast majority of games this coming weekend, which features three ranked-on-ranked matchups (assuming #22 Memphis falls out after losing 31-24 at UAB as 23.5-point favorites), headlined by Ole Miss vs Oklahoma, Missouri vs Vanderbilt, and Texas A&M vs LSU.

The table below lists the opening NCAAF Week 9 odds for all power-conference games and games involving top-25 teams. Under the table, find my favorite NCAAF Week 9 picks and early lines to target.

College Football Week 9 Odds

TeamSpreadMLTotal
Cal+3.5 (-110)+164O 50.5 (-110)
Virginia Tech-3.5 (-110)-198U 50.5 (-110)
TeamSpreadMLTotal
#5 Ole Miss+3.5 (-110)+150O 50.5 (-110)
#14 Oklahoma-3.5 (-110)-180U 50.5 (-110)
TeamSpreadMLTotal
UCLA +24.5 (-110)+1700O 51.1 (-110)
#3 Indiana-24.5 (-110)-4500U 51.1 (-110)
TeamSpreadMLTotal
Kansas State+2.5 (-110)+114O 54.5 (-110)
Kansas-2.5 (-110)-135U 54.5 (-110)
TeamSpreadMLTotal
Illinois+3.5 (-110)+145O 54.5 (-110)
Washington-3.5 (-110)-175U 54.5 (-110)
TeamSpreadMLTotal
Michigan-12.5 (-110)TBDTBD
Michigan State+12.5 (-110)TBDTBD
TeamSpreadMLTotal
Minnesota+7.5 (-110)TBDTBD
Iowa-7.5 (-110)TBDTBD
TeamSpreadMLTotal
Northwestern+8.5 (-110)+285O 42.5 (-110)
#25 Nebraska-8.5 (-110)-360U 42.5 (-110)
TeamSpreadMLTotal
#18 Virginia-10 (-110)-380O 52.5 (-110)
North Carolina+10 (-110)+300U 52.5 (-110)
TeamSpreadMLTotal
Syracuse+18.5 (-110)+650O 54.5 (-110)
#12 Georgia Tech-18.5 (-110)-1000U 54.5 (-110)
TeamSpreadMLTotal
Rutgers-2.5 (-110)-130O 58.5 (-110)
Purdue+2.5 (-110)+110U 58.5 (-110)
TeamSpreadMLTotal
SMU-4.5 (-110)-170O 54.5 (-110)
Wake Forest+4.5 (-110)+142U 54.5 (-110)
TeamSpreadMLTotal
Auburn+1.5 (-110)-102O 55.5 (-110)
Arkansas-1.5 (-110)-118U 55.5 (-110)
TeamSpreadMLTotal
#21 Texas-6.5 (-110)-245O 44.5 (-110)
Mississippi State+6.5 (-110)+200U 44.5 (-110)
TeamSpreadMLTotal
#16 Missouri+3 (-110)+124O 51.5 (-110)
#17 Vanderbilt-3 (-110)-148U 51.5 (-110)
TeamSpreadMLTotal
#15 BYU+1.5 (-110)+110O 49.5 (-110)
Iowa State-1.5 (-110)-130U 49.5 (-110)
TeamSpreadMLTotal
#6 Alabama-13.5 (-110)-575O 46.5 (-110)
South Carolina+13.5 (-110)+425U 46.5 (-110)
TeamSpreadMLTotal
NC State+7.5 (-110)+260O 57.5 (-110)
Pitt-7.5 (-110)-315U 57.5 (-110)
TeamSpreadMLTotal
Baylor+5.5 (-110)O .5 (-110)
#24 Cincinnati-5.5 (-110)U .5 (-110)
TeamSpreadMLTotal
TCU-14.5 (-110)-535O 56.5 (-110)
West Virginia+14.5 (-110)+400U 56.5 (-110)
TeamSpreadMLTotal
Stanford +30.5 (-110)TBDTBD
#2 Miami-30.5 (-110)TBDTBD
TeamSpreadMLTotal
#4 Texas A&M-2.5 (-110)-135O 49.5 (-110)
#10 LSU+2.5 (-110)+114U 49.5 (-110)
TeamSpreadMLTotal
Boston College+22.5 (-110)+1300O 54.5 (-110)
Louisville-22.5 (-110)-2800U 54.5 (-110)
TeamSpreadMLTotal
#11 Tennessee+9.5 (-110)-340O 52.5 (-110)
Kentucky-9.5 (-110)+270U 52.5 (-110)
TeamSpreadMLTotal
Houston+7 (-110)+215O 49.5 (-110)
Arizona State-7 (-110)-365U 49.5 (-110)
TeamSpreadMLTotal
Colorado+14.5 (-110)+425O 49.5 (-110)
Utah-14.5 (-110)-575U 49.5 (-110)

No ranked teams play before Saturday, October 25th, in Week 9. Only one power-conference game takes place before the weekend: Cal vs Virginia Tech on Friday, October 24th.

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Odds as of 12:51 pm ET, October 19th, at DraftKings. Download the top college football betting apps ahead of Week 9.

The #1 Ohio State Buckeyes remain the outright favorites in the national championship odds at +275, head-and-shoulders ahead of second-favorite Alabama (+600).

Early Week 9 Prediction: Vanderbilt (-3) over Missouri

The Vanderbilt Commodores () continued their brilliant season in Week 8 with a 31-24 home victory over #10 LSU, covering as 2.5-point chalk. In Week 9, they get to stay home against another ranked opponent, #16 Missouri, which is coming off a 23-17 double-OT win at Auburn as 1.5-point favorites.

Both teams have just one loss this season, and both came to Alabama. Missouri fell 27-24 at home to the Tide in Week 7. Vanderbilt lost 30-14 at Alabama in Week 6.

The ESPN FPI has these teams at a nearly identical numbers. Missouri is 17th in the nation at 15.9 while Vanderbilt is 18th at 15.5. But I’m fully sold on Vanderbilt as a legitimate national power this season. They were full value for their win over LSU, outgaining the Tigers 399-325 and holding the ball for 36:31. No one has really proven they can stop the Vandy ground game, which just put up 239 yards on a good LSU defense. With homefield advantage once again, the Commodores are my favorite early ATS pick in Week 9.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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