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Diamondbacks vs Cubs Odds and Picks (May 20)

John Perrotto

by John Perrotto in MLB Baseball

May 19, 2022 · 9:55 PM PDT

Arizona Diamondbacks third baseman Josh Rojas celebrating at home plate
May 19, 2022; Chicago, Illinois, USA; Arizona Diamondbacks third baseman Josh Rojas (10) celebrates with center fielder Jordan Luplow (8) after scoring against the Chicago Cubs during the fourth inning at Wrigley Field. Mandatory Credit: Kamil Krzaczynski-USA TODAY Sports
  • The Cubs are -130 favorites over the Diamondbacks on Friday
  • Humberto Castellanos (2-1, 4.15) will start for Arizona against Kyle Hendricks (2-3, 4.03)
  • A look at the Diamondbacks vs Cubs odds and matchup can be found below with a prediction

After getting back on the winning track, the Arizona Diamondbacks visit the Chicago Cubs at 2:20 p.m. ET Tuesday in the second game of their four-game series at Wrigley Field.

The Diamondbacks (19-21/9-10 road) snapped a six-game losing streak Thursday night by beating the Cubs 3-1 in the series opener. The Cubs (15-22/6-13 home) have lost consecutive games following a four-game winning streak.

Diamondbacks vs Cubs Odds

Team Moneyline Runline Total
Arizona Diamondbacks +112 OFF OFF
Chicago Cubs -130 OFF OFF

Odds as of May 19th at Barstool Sportsbook.


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The Cubs are -130 favorites in a game that will be televised on MLB Network, giving them an implied win probability of 56.52%. Both teams have long World Series odds as the Cubs are listed at +25000 and the Diamondbacks are +50000 shots.

The weather forecast calls for partly sunny and breezy, a high temperature of 84 degrees and wind from the southwest at 15-20 mph and gusting to 35 mph.

Arizona vs Chicago Probable Pitchers

Humberto Castellanos (2-1, 4.15) is scheduled to start for the Diamondbacks against Kyle Hendricks (2-3, 4.03). Castellanos will be pitching on four days of rest and Hendricks on five.

Castellanos vs Hendricks

Visitor Starter
Home Starter
2-1 Record 2-3
4.15 ERA 4.03
3.66 xERA 4.75
1.19 WHIP 1.25
2.63 SO/W 2.13

Castellanos faced the Cubs last Sunday in Phoenix and had a no-decision, giving up two runs on five hits in 5.1 innings with five strikeouts and one walk. It was his first-ever appearances versus Chicago.

This will be Castellanos’ fourth start of 2022 on the road, where he 1-1 with a 3.86 ERA. He has no decisions and a 3.48 ERA in two starts during the day.

Hendricks also pitched in Phoenix his last time out last Saturday and had a no-decision against the Diamondbacks. In 5.2 innings, he allowed one run and five hits while striking out two and walking two.

Against the Diamondbacks in his career, Hendricks has a 4-2 record and 2.94 ERA in eight starts.

Hendricks is 1-1 with a 2.82 ERA in four starts at home this season and 1-1 with a 3.94 ERA in three starts in day games.

Christian Walker is 4 for 10 with a double against Hendricks but Ketel Marte is 2 for 11 (.182) with four strikeouts.

Diamondbacks vs Cubs Betting Outlook

Daulton Varsho homered to lead off a three-run fourth inning and the Diamondbacks held on to beat the Cubs on Thursday night.

Josh Rojas and David Peralta added RBI singles later in the inning to push the lead to 3-0. The Cubs also got their lone run in the fourth when Yan Gomes’ double concluded the scoring.

The Cubs were 1 for 7 with runners in scoring position and left nine runners on base.

The Diamondbacks placed catcher Jose Herrera on the injured list prior to the game with no injury designation. That likely means it is related to COVID-19.

Catcher Grayson Greiner was called up from Triple-A Reno and will likely start Friday in a day game following a night game. Varsho was behind the plate Thursday.

Greiner played in 137 games for the Detroit Tigers in four seasons from 2018-21.

Second baseman Jonathan Villar is expected to be back in the Cubs’ lineup after getting Thursday off following a stretch of starting eight games in a row.

The teams have split four games this year and the Cubs hold a 26-16 edge in the series since the start of the 2015 season.

Diamondbacks vs Cubs Last 10 Games

Date Home Team Away Team Score
5/19/22 Cubs Diamondbacks ARI, 3-1
5/15/22 Diamondbacks Cubs CHC, 3-2
5/14/22 Diamondbacks Cubs CHC, 4-2
5/13/22 Diamondbacks Cubs ARI, 5-4
7/25/21 Cubs Diamondbacks CHC, 5-1
7/24/21 Cubs Diamondbacks ARI, 7-3
7/23/21 Cubs Diamondbacks CHC, 8-3
7/18/21 Diamondbacks Cubs ARI, 6-4
7/17/21 Diamondbacks Cubs CHC, 4-2
7/16/21 Diamondbacks Cubs CHC, 5-1

Diamondbacks vs Cubs Prediction

The Cubs have struggled at home this season, but it is hard to overlook Hendricks’ fine history against the Diamondbacks. Chicago is the way to go in this one.

Pick: Cubs ML (-130)


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