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Opening College Football Week 10 Odds, Spreads and Early Predictions

John Perrotto

by John Perrotto in College Football

Oct 30, 2022 · 12:40 PM PDT

Georgia Bulldogs running back Daijun Edwards celebrates a TD versus Florida
Oct 29, 2022; Jacksonville, Florida, USA; Georgia Bulldogs running back Daijun Edwards (30) is congratulated after he scores a touchdown against the Florida Gators during the first quarter at TIAA Bank Field. Mandatory Credit: Kim Klement-USA TODAY Sports
  • The Power Five portion of Week 10 begins Friday night when Duke visits Boston College
  • The biggest game of the week is #2 Tennessee vs #1 Georgia on Saturday, Nov. 5
  • A look at the NCAAF Week 10 opening odds for can be found below with early predictions

The Power Five portion of Week 10 of the college football season begins Friday when Duke visits Boston College at 7:00 p.m. ET in an ACC game.

Duke (5-3, 2-2 ACC) is favored by 9.5 points after being off this weekend. Boston College (2-6, 1-4 ACC) has lost three games in a row, including 13-3 at Connecticut on Saturday.

The biggest game of the season to this point is Saturday when #2 Tennessee visits #1 Georgia in an SEC showdown. Two other games involving ranked teams that day are #6 Alabama at #15 LSU in the SEC and #20 Wake Forest at #21 North Carolina State in the ACC.

The college football odds will be updated throughout the week.

College Football Week 10 Opening Odds

Game Time (Eastern) Team Spread Moneyline
Friday, Nov. 4 Duke -9.5 (-110) OFF
7 p.m. Boston College +9.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Friday, Nov. 4 Oregon State +4.5 (-110) OFF
10:30 p.m. Washington -4.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Minnesota -10.5 (-110) OFF
12 p.m. Nebraska +10.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 4 Iowa +4.5 (-110) OFF
12 p.m. Purdue -4.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Texas Tech +9.5 (-110) OFF
12 p.m. TCU -9.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Florida +3.5 (-110) OFF
12 p.m. Texas A&M -3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Maryland +6.5 (-110) OFF
12 p.m. Wisconsin -6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Ohio State -36.5 (-110) OFF
12 p.m. Northwestern +36.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Kentucky -1.5 (-110) OFF
12 p.m. Missouri +1.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 North Carolina -9.5 (-110) OFF
12 p.m. Virginia +9.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Tulane -7 (-110) OFF
12 p.m. Tulsa +7 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Georgia Tech +4.5 (-110) OFF
12:30 p.m. Virginia Tech -4.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Baylor +3.5 (-110) OFF
3 p.m. Oklahoma -3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Michigan State +15 (-110) OFF
3:30 p.m. Illinois -15 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 West Virginia +5.5 (-110) OFF
3:30 p.m. Iowa State -5.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Washington State -3 (-110) OFF
3:30 p.m. Stanford +3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Tennessee +9 (-110) OFF
3:30 p.m. Georgia -9 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Oregon -29 (-110) OFF
3:30 p.m. Colorado +29 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Oklahoma State -3.5 (-110) OFF
3:30 p.m. Kansas +3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Penn State -14 (-110) OFF
3:30 p.m. Indiana +14 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Syracuse +2.5 (-110) OFF
3:30 p.m. Pittsburgh -2.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 UCF -5.5 (-110) OFF
3:30 p.m. Memphis +5.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Liberty +14.5 (-110) OFF
4 p.m. Arkansas -14.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Texas -1 (-110) OFF
7 p.m. Kansas State +1 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Alabama -12.5 (-110) OFF
7 p.m. LSU +12.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 James Madison +10 (-110) OFF
7:30 p.m. Louisville -10 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Florida State -7.5 (-110) OFF
7:30 p.m. Miami +7.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Auburn +11.5 (-110) OFF
7:30 p.m. Mississippi State -11.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Michigan -24.5 (-110) OFF
7:30 p.m. Rutgers +24.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Clemson -3.5 (-110) OFF
7:30 p.m. Notre Dame +3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 South Carolina -7.5 (-110) OFF
7:30 p.m. Vanderbilt +7.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Arizona +17 (-110) OFF
7:30 p.m. Utah -17 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 Wake Forest -3 (-110) OFF
8 p.m. NC State +3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 4 California +19 (-110) OFF
10:30 p.m. USC -19 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
Saturday, Nov. 5 UCLA -9.5 (-110) OFF
10:30 p.m. Arizona State +9.5 (-110) OFF

Odds as of October 30th at DraftKings Sportsbook.

Ohio State is the week’s biggest opening favorite at 36.5 points over Northwestern on the road. The smallest line is the one point by which visiting Texas is favored over Kansas State.

 

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Tennessee vs Georgia Early Odds & Prediction

When Tennessee (8-0, 4-0 SEC) and Georgia (8-0, 5-0 SEC) meet in Athens, it will mark the first game between the top two teams in the AP media poll since #1 LSU played #2 Alabama in 2019.  Georgia is favored by nine points.

Tennessee tuned up for the showdown by routing visiting Kentucky 44-6 on Saturday night. Jalin Hyatt led the Volunteers by catching five passes for 138 yards and two touchdowns, raising his season total to a school-record 14 TD receptions.

Tennessee intercepted Will Levis three times and held him to 98 yards passing. The Wildcats were just 2 of 13 on third down.

Daijun Edwards and Kenny McIntosh ran for two touchdowns each to lead Georgia over Florida 42-20 in Jacksonville in the “World’s Largest Outdoor Cocktail Party.” Edwards had 106 yards rushing and McIntosh finished with 90.

Stetson Bennett completed 19 of 38 passes for 316 yards with two touchdowns and two interceptions. Tight end Brock Bowers caught five passes for a career-high 154 yards, including a 73-yard score in which he hauled in a ball that was tipped.

Georgia is the defending national champion and playing well. However, surprising Tennessee has proven it is not a fluke and quarterback Hendon Hooker should at least keep the Vols close.

Pick: Tennessee +9 (-110)

Alabama vs LSU Early Odds & Prediction

This matchup has lost a little luster in the last few years, but it is still a pivotal game in the SEC. Alabama is a 12.5-point road favorite in Baton Rouge. Both teams were off this weekend.

Alabama (7-1, 4-1 SEC) beat Mississippi State 30-6 on Oct. 22. It was a nice bounce-back win after the Crimson Tide lost to Tennessee 52-49 the previous week.

Alabama quarterback Bryce Young has thrown for 1,906 yards while battling injuries. Georgia Tech transfer Jahmyr Gibbs has rushed for 672 yards in his first season with the Tide.

LSU (6-2, 4-1 SEC) has won back-to-back games, including upsetting Mississippi 45-20 on Oct. 22.

Brian Kelly has done a good job of getting LSU back on track in his first season as coach. However, Alabama showed it is back on track after dismantling Mississippi State and should handle the Tigers.

Pick: Alabama -12.5 (-110)

That’s Outta Line

The season has fallen apart for Michigan State (3-5, 1-4 Big Ten), which lost 29-7 at Michigan on Saturday night for its fifth loss in the last six games. Compounding matters was Michigan State players attacking a Michigan player after the game in the tunnel leading to the locker rooms in Ann Arbor.

#14 Illinois (7-1, 4-1) is one of the nation’s surprise teams and won its sixth game in a row Saturday, beating Nebraska 26-9 on the road. The Fighting Illini lead the Big Ten West.

While the programs are going in opposite directions, Illinois being installed as a 15-point home favorite over Michigan State for Saturday’s matchup seems high. The talent gap isn’t two touchdowns between the programs.

 

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