Opening College Football Week 2 Odds, Spreads and Early Predictions

• Week 2 of the college football season features two games between ranked teams
• The top matchup has #4 Alabama hosting #11 Texas
• All the college football Week 2 opening odds can be found below with early predictions

A pair of games involving ranked teams highlight Week 2 of the college football season.

On Saturday night at Bryant-Denny Stadium in Tuscaloosa, #4 Alabama will host #11 Texas. Earlier in the day, #22 Ole Miss will visit #24 Tulane at Yulman Stadium in New Orleans.

Alabama opens as an eight-point favorite and Ole Miss is a six-point pick. The table below displays the college football odds on the board as of Sunday morning. The odds will be updated throughout the week.

College Football Week 2 Opening Odds

Top-ranked Georgia is the biggest Week 2 opening favorite as a 48.5-point choice over Ball State. Colorado and Coach Prime (Deion Sanders) is the slimmest favorite at 2.5 points over visiting Nebraska.

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Odds as of September 5th at DraftKings. Claim this week’s DraftKings promo to bet on college football Week 2 action and check out the early college football props for this weekend’s games. 

Texas vs Alabama Early Odds & Prediction

Both teams defeated Group of Five schools on Saturday in their season openers with Alabama routing Middle Tennessee State 56-7 and Texas handling Rice 37-10.

After winning a three-way competition for the starting job, Alabama quarterback Jalen Milroe threw three touchdown passes covering 47, 48 and 29 yards while also rushing for two scores. Texas QB Quinn Ewers also got off to a strong start with three scoring passes and one rushing TDs.

Jalen Milroe earned a 92.3 offensive grade from Pro Football Focus, the ninth-highest among Division I quarterbacks this weekend.

For reference, Bryce Young only had two games where he graded higher last season: Vanderbilt (92.8) and Arkansas (94.7) pic.twitter.com/JA0egfowGV

— Tony Tsoukalas (@Tony_Tsoukalas) September 3, 2023

It might only be one game as QB1, but Milroe certainly looks like a potential star for the Crimson Tide as he takes over for 2021 Heisman Trophy winner Bryce Young, giving confidence Alabama can cover the spread in this matchup.

Pick: Alabama -8 (-110)

Ole Miss vs Tulane Early Odds & Prediction

Both teams, as expected, opened their seasons with wins on Saturday. Ole Miss throttled Mercer 73-7 and Tulane defeated South Alabama 37-17.

Ole Miss’ Jaxson Dart threw for 334 yards in barely more than two quarters and connected with Tre Harris for three touchdown passes in the first four minutes of the game. Tulane quarterback Michael Pratt had a very efficient performance as he completed 14 of 15 passes for 294 yards and four TDs.

QB1's Q1 ➡️ @JaxsonDart

11-for-11
254 total yards
3 TDs pic.twitter.com/DspxhSJqyy

— Ole Miss Football (@OleMissFB) September 2, 2023

While Ole Miss is favored, this is a tough spot for the Rebels as they play on the road against the only ranked Group of Five team. Look for Tulane to slip under the number if not win outright.

Pick: Tulane +6 (-110)

That’s Outta Line

Visiting #14 Utah has opened as a 5.5-point favorite over Baylor. However, that line seems a little light based on the season-opening results for both teams.

Utah handled Florida 24-11 while Baylor was upset by Texas State 42-31. It seems that the Utes should be bigger favorites, so look for this line to go higher.

Looking for updated college football Week 2 odds? Check out the latest betting lines for Nebraska vs Colorado, Texas vs Alabama and more.