Stanford vs Washington Odds and Picks

• No. 18 Washington is a 14.5-point favorite over Stanford in its Pac-12 opener on Saturday
• The Huskies are 3-0 ATS in 2022, while the Cardinal are 0-2 ATS
• Read below for Stanford vs Washington odds, analysis, and betting prediction

No. 18 Washington is a 14.5-point home favorite as the Dawgs look to remain perfect in 2022 against Stanford at Husky Stadium in Seattle on Saturday (September 24th) at 10:30 pm ET on FS1. The all-time series is deadlocked at 44-44-4, with the Huskies winning last year’s game 20-13 on The Farm.

The Cardinal are 0-2 ATS so far this season with all five games involving both teams hitting the over.

Let’s analyze the Stanford vs Washington odds and find the best bet for Saturday’s Week 4 game.

Stanford vs Washington Odds

Odds as of September 21st at Barstool Sportsbook. See the available ESPN Bet promo code for the best sign-up offer.

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Washington is -590 on the moneyline in the college football odds, meaning they have 85.5% implied win probability.

Depleted Stanford Attack

Even though the Cardinal are coming off a bye week, the extra rest following a 41-28 home loss to USC in Week 2 won’t be enough for running back EJ Smith to be active for Saturday’s tilt. Smith — who has 206 rushing yards and three touchdowns in two games and ranks 17th in the country in yards per carry — is out. That puts extra pressure on unproven backup tailback Casey Filkins and quarterback Tanner McKee, who has a 3:3 touchdown-to-interception ratio. The highly-touted NFL Draft prospect is averaging 8.5 yards per pass this season and owns a completion percentage of 68%.

UW co-DC William Inge called Stanford QB Tanner McKee one of the elite QBs in the country. He said McKee can make throws that only "two or three quarterbacks in the country can make."

— Mike Vorel (@mikevorel) September 19, 2022

Meantime, the Stanford defense got smoked by the Trojans the last time we saw this team in action. USC quarterback Caleb Williams had 244-yards passing on 13-of-15 passing and four touchdowns — in the first half! The Cardinal made adjustments in the second half, giving up just 97 yards passing in the second 30 minutes — but the damage had been done. Now, the group will try to defend a similar spread offense in a hostile environment.

Michael Penix Jr.: 11 completions on throws 20+ yards

Leads all Power 5 QBs👀🍿 pic.twitter.com/ZwMtdH6wWM

— PFF College (@PFF_College) September 19, 2022

One thing Stanford has in its favor is history. The Cardinal have 29 wins against nationally-ranked opponents under head coach David Shaw. Five of those victories have come against Washington, and Stanford is 5-1 when facing a Huskies team ranked in the Top 25.

Purple Reign Return?

Negative trends aside, the Dawgs appear to be poised for a return to glory. UW is led by Indiana transfer QB Michael Penix Jr, who has passed for 10 touchdowns so far in 2022 and won Pac-12 Offensive Player of the Week after he passed for 397 yards, the eighth-highest single-game total in school history, against then-No. 11 Michigan State.

Really enjoyed watching Michael Penix Jr this week against Michigan State.

10:1 TD/INT through three weeks and he looks like a completely different talent than what he was at IU.

His 11 completions on throws 20+ yards downfield lead all P5 QBs.

pic.twitter.com/hncOhmNNbr

— Ryan Fowler (@_RyanFowler_) September 20, 2022

Penix has led a quick strike UW offense, with the Huskies scoring on 14-of-16 first-half possessions (with 12 of those 14 going for touchdowns). The offensive line has been stout, allowing only two sacks in three games — with both of those coming after the starters were out. Through the first three weeks, Washington’s offense leads the conference in pass offense (2nd in FBS), total offense (4th in FBS), first downs (5th in FBS) and third-down conversion percentage (8th in FBS).

And if all those offensive superlatives weren’t enough, the UW defense leads the Pac-12 in rush defense and is second in total defense.

Stanford vs Washington Prediction

A pair of turnovers inside the five-yard line killed Stanford’s chance to upset USC two weeks ago. That inability to finish drives with touchdowns (along with two other turnovers) spoiled a 441 yard day with 33 first downs of offense. Now, this group will try to manufacture a similar output on the road without a key cog (Smith) available on offense.

The Cardinal have performed well historically against the Huskies — and there’s a letdown danger in this spot for the Dawgs.  But simply put, Penix and Co. are operating at a very high level right now and Stanford’s defense will be hard-pressed to stop it.

The pick: Washington – 14.5 (-110)