Bills vs Rams Odds, Betting Lines, Picks & Predictions for 2022 NFL Season-Opener
By Robert Duff in NFL Football
Published:
- Can the Buffalo Bills bring a halt to the season-opening win streak of the Los Angeles Rams when the two clubs open the NFL season on Thursday, September 8?
- The Rams are 5-0 straight up and against the spread in Week 1 over the past five seasons
- Buffalo is 4-1 SU and ATS in the last five games facing the Rams
Both the Los Angeles Rams and Buffalo Bills are bringing solid success stories into their Week 1 NFL clash.
The Rams are the reigning Super Bowl champions. However, it’s Buffalo that is the favorite in the Super Bowl odds this season.
The Bills are also being set as 2.5-point road favorites over the Rams in the season opener for both teams. Buffalo is 4-1-1 against the spread over the past six games.
Bills vs Rams NFL Week 1 Odds
| Team | Spread | Total | Moneyline |
|---|---|---|---|
| Buffalo Bills | -2.5 (-110) | O 52 (-110) | -135 |
| Los Angeles Rams | +2.5 (-110) | U 52 (-110) | +115 |
Odds as of September 7 at Caesars Sportsbook. See the available Caesars Sportsbook promo code for the NFL here
Bet $1 & Double Your Winnings On Your First 10 Bets!
Kickoff at SoFi Stadium is set for 8:20 pm ET. The weather forecast is calling for clouds, 6 mph wind and a temperature of 75 degrees. NBC is carrying the broadcast, but it can also be streamed via fuboTV. In Canada, the action is available through TSN and DAZN.
Bills vs Rams NFL Betting Trends
In order to beat the Rams, Buffalo must overcome the Week 1 perfection of the Rams under head coach Sean McVay. Since he took over as coach in 2017, LA is 5-0 both straight up and ATS in Week 1 of the season. However, this is the first time the Rams have ever opened the season under McVay as betting underdogs. Last season, LA was 3-0 ATS as an underdog.
The Rams kick off the season against the Bills this Thursday.
Will McVay make himself 6-0? pic.twitter.com/CqgsoClY67
— FOX Sports: NFL (@NFLonFOX) September 7, 2022
Buffalo has its own betting trend to draw upon. The Bills are 4-1 both SU and ATS in the past five games against the Rams. Buffalo hasn’t lost a game to the Los Angeles Rams since 1983. However, the Bills did lose twice since then to the St Louis Rams. The Bills opened as the 2.5-point chalk over the Rams and the line hasn’t moved.
In NFL public betting trends, people are on board with Buffalo. Spread wagering is showing 74% of handle and 68% of bets are on Buffalo. In moneyline wagering, 61% of handle and 56% of bets are backing Buffalo. The over is getting the action on the total. There’s 64% of handle and 60% of bets supporting the teams going over 52 points. Buffalo has scored at least 30 points in seven of the last eight games against the Rams.
Rams QB Stafford Nursing Tendinitis In Elbow
Rams quarterback Matthew Stafford is playing with tendinitis in his throwing elbow. He insists it’s a manageable pain level. Stafford was playing with a similar ailment last season. He threw for 41 touchdowns against 17 interceptions.
The Rams are entering the NFL season as a relatively healthy bunch. Wide receiver Van Jefferson, who underwent minor knee surgery at the beginning of August, is listed as questionable.
Leslie Frazier says the #Bills are going to "mix it up" with Kaiir Elam and Christian Benford Thursday night.
This plan comes with Tre'Davious White on PUP to start season.
Frazier explains how that decision is actually a benefit to the defense. pic.twitter.com/FHGLLO2UX9
— Jon Scott (@JonScottTV) September 5, 2022
Buffalo placed All-Pro cornerback Tre’Davious White on the reserve/PUP list on Tuesday. That means he’ll be out for the first four weeks of the NFL season.
Will Allen, Stafford Air It Out?
Caesars Sportsbook is offering a Week 1 super boost with a maximum bet of $25. Bet on Stafford and Bills QB Josh Allen to both top 249.5 in passing yardage in your Bills vs Rams prop bets and get odds of +125.
Week one preview: Bills vs Rams.
• Last matchup was in 2020 where the Bills defeated the Rams: 35-32. Josh Allen threw for 311 yards and 4 touchdowns. (One rushing TD as well.)
• Josh Allen and Matthew Stafford have never faced off.
┃#BillsMafia #RamsHouse pic.twitter.com/7DypPdIBxh
— SGG X Stake.US (@SGGXStakeUS) August 29, 2022
A winning wager at the maximum amount of $25 offers an implied probability of success of  44.44% and a payout of $56.25.
Bills vs Rams Prediction
Neither the Rams (5-7, .417) or Bills (3-6, .333) are especially successful when playing on Thursday. The Bills are 1-4 SU and ATS in their past five Thursday games.
In the only previous Week 1 meeting between these two teams, Buffalo walloped the Rams 40-19 at home to open the 1992 NFL season. The last meeting in Buffalo in 2019 saw the Bills outscore the Rams 35-32. Buffalo squandered a 28-3 lead in that game and needed a rally to come back from a 32-28 deficit.
https://twitter.com/OlliePicks/status/1567518802979561472?s=20&t=JiNsM3_W1jLB7Vf8SvV-4A
The defending Super Bowl champions are 38-16-1 SU all-time in Week 1. Reigning NFL champs are 13-7-2 ATS in Week 1 since the 2000 season. McVay is seeking to become the first NFL coach to win six straight home openers since Mike Shanahan (1993-98).
Bills coach Sean McDermott is 3-2 SU in home openers. Last season, Buffalo blew a 10-point halftime lead in Week 1 and lost at home to the Pittsburgh Steelers.
Pick: Los Angeles Rams +2.5 (-110)
Sports Writer
An industry veteran, Bob literally taught the course on the history of sports at Elder College. He has worked as a Sports Columnist for Postmedia, appeared as a guest on several radio stations, was the Vice President of the Society For International Hockey Research in Ontario, and written 25 books.
