Buffalo Bills vs LA Chargers Prediction, Lines and Odds Week 16 Saturday Night Football

• Saturday Night Football features Buffalo expected to easily coast to victory over the LA Chargers as 12.5-point favorites
• Both teams are 10-4 to the Under in totals betting this season
• Get the Bills vs Chargers odds, picks, and predictions for Saturday night here

The Bills are suddenly rolling, now 8-6 SU after two straight wins and go to Los Angeles to face the spiralling Chargers, 5-9 SU on Saturday night. Buffalo comes in as huge 12.5-point favorites in the Bills vs Chargers odds looking likely to push that winning streak to three games.

Read on for the full Bills vs Chargers odds and our top Buffalo vs Los Angeles prediction here.

 Bills vs Chargers Odds

Buffalo at -12.5 and -900 favorites on the moneyline have an implied probability of 90% to win in the Bills vs Chargers odds. The total has risen from 42.5 to 43.5 with the Over still juiced to -115.

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How to Watch Buffalo vs LA

Viewers in the United States can watch this Bills vs Chargers game on Saturday night on Peacock while viewers in Canada can watch on DAZN or TSN.

Bills vs Chargers Head-to-Head History

These teams last played in 2020 with Buffalo winning 27-17. Los Angeles has won six of eight recent games but that goes way back to 2005, so there’s no real recent history to consider for this weekend.

Buffalo vs Los Angeles Public Betting Trends

Both the money and bet count percentages are well over 70% on the Bills in NFL public betting for this game when it comes to against the spread picks. The money count is more split on the moneyline, but over 90% of the bets are backing Buffalo to win straight up. There is also a huge concensus on the Over in Bills vs Chargers public betting.

Bills Heating Up With Wins Over Cowboys & Chiefs

It was only a few weeks ago that the Bills looked in serious jeopardy of missing the playoffs after just one win in four games and that win coming against the Jets.

But Buffalo went to overtime with the Eagles before losing 37-34 in Week 13, and then won 20-17 over Kansas City in Week 14 and 31-10 over Dallas last weekend in Week 15.

Buffalo rolled a Dallas team that had looked like one of the best teams in the league having been on a five-game winning streak.

They did so with Josh Allen only throwing for 94 yards and one touchdown. But the run game was more than enough to get the job done with James Cook rushing for 179 yards and the Bills combining for 266 total rushing yards.

"I think he very well may be bringing himself into the MVP conversation with how he has played in those big games."@jjones9 loves how much Josh Allen has been stepping up when it matters most pic.twitter.com/kFh8N3XSlK

— NFL on CBS 🏈 (@NFLonCBS) December 18, 2023

Chargers Allow Most Points in Franchise History, Fire Staley

This Chargers team already looked dead in the water with just one win in five games prior to last week’s Thursday Night Football game. That one win was a hideous 6-0 win over New England.

Then they went on the road to Las Vegas and got completely run off the field in losing 63-21. That cost head coach Brandon Staley and general manager Tom Telesco their jobs. Giff Smith, outside linebackers coach, has been tabbed as the interim head coach and JoJo Wooden interim GM.

"It doesn't happen very often where the story I'm talking about has breaking news while I'm talking about it."

— @ColinCowherd reacts in real-time to Chargers firing Brandon Staley pic.twitter.com/g8L4uUcOuT

— Herd w/Colin Cowherd (@TheHerd) December 15, 2023

Easton Stick did throw for 257 yards and three touchdowns, but all of that was in garbage time as the Raiders led 42-0 at halftime, 49-0 in the third quarter and even 63-7 in the fourth quarter.

So it’s losses in five of six for LA, in a stretch that has seen them score an average of 12.8 PPG in their last five. The Chargers are also one of the worst ATS teams being just 5-9 ATS, a mark that is better than only four teams.

Bills vs Chargers Head-to-Head Stats

*Stats heading into Week 16

Bills vs Chargers Prediction

Not only has LA been losing SU of late, but they’re also 1-5 ATS in their past six. However, they’ve never been double-digit underdogs this season.

The Chargers are 10-4 to the Under this season and are currently on 4-1 and 10-2 Under runs.

After a streak that saw them go 0-6 ATS, Buffalo is now 3-1 ATS in their past four.

Buffalo just held Dallas (10) and Kansas City (17) to a combined 27 points which has resulted in their past two games going Under. They’re 10-4 to the Under overall, tied for the highest number of Unders and are 6-1 to the Under in their past seven.

After huge wins over Dallas and KC, this could look like a letdown spot for the Bills. And the Chargers could get that “new coach bump” with Staley out the door. But Buffalo is just rounding into form after a poor stretch a few weeks ago. They can still win the AFC East and are still on the outside looking in for the playoffs. And … the Chargers have Easton Stick at QB.

Allen is third in touchdown passes and should carve up the Chargers’ 30th ranked secondary. This is no time to let up for Buffalo and they should cruise to victory.

Bills vs Chargers Picks: Bills (-12.5)

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