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Opening Bills vs Saints Odds and Betting Lines for Thanksgiving TNF Week 12

Robert Duff

by Robert Duff in NFL Football

Updated Nov 21, 2021 · 6:36 PM PST

Trevor Siemian rushes for a touchdown
New Orleans Saints quarterback Trevor Siemian (15) runs for a touchdown as Philadelphia Eagles free safety Anthony Harris (28) defends during the fourth quarter of an NFL football game Sunday, Nov. 21, 2021, in Philadelphia. The Eagles defeated the Saints 40-29. (AP Photo/Rich Schultz)
  • The Buffalo Bills are 3.5-point road favorites over the New Orleans Saints in the NFL’s Week 12 edition of TNF on November 25
  • New Orleans are losers of three in a row, while Buffalo is 1-2 over the past three games
  • Read below for opening odds analysis and a prediction on which way the line will move leading up to kickoff

Once thought to be certain playoff clubs and even Super Bowl contenders, both the Buffalo Bills and New Orleans look nothing of the sort of late.

The Bills have lost two of three, including a setback at the hands of the 2-8 Jacksonville Jaguars. New Orleans are winless in three games, two of those losses suffered against below-.500 teams.

With the two teams set to meet in the Week 12 edition of TNF, it’s the visiting Bills that the oddsmakers are opting to stick with through these uncertain times. Buffalo is set as a 3.5-point road favorite. The Bills are 2-2 against the spread as the away chalk this season.

Bills vs Saints Opening Odds

Team Moneyline Spread Total
Buffalo Bills -198 -3.5 (-114) O 47 (-110)
New Orleans Saints +205 +3.5 (-106) U 47 (-110)

Odds as of November 21st at FanDuel.

Kickoff for the third game of the NFL’s Thanksgiving tripleheader is set for 8:20 pm ET inside the climate-controlled confines of Caesars Superdome. FOX Sports is carrying the broadcast.

New Orlean Saints Betting Trends

Perhaps those other NFL teams who had him weren’t wrong and Trevor Siemian isn’t the answer at quarterback for New Orleans after all. The Saints turned the ball over three times in Sunday’s 40-29 drubbing handed to them by the Philadelphia Eagles.

Two of them were first-half interceptions tossed by Siemian. Both resulted in Philly touchdowns, including a 51-yard pick-six by Darius Slay.  They played a significant role in the Saints’ 27-7 halftime deficit. When he wasn’t turning it over, Siemian was turning in three-and-outs that were exhausting the New Orleans defense.

The Saints have other issues on top of poor QB play. They’re missing seven offensive starters. These include running back Alvin Kamara (knee), the NFL’s #1 all-purpose yardage player, and both of their Pro Bowl tackles – Terron Armstead (knee/shoulder) and Ryan Ramczyk (knee).

Buffalo Bills Betting Trends

What’s happening to the once-mighty Bills? They entered Week 11 play as the +600 Super Bowl favorites. Then, they went out at home and did an absolute face plant in a 41-15 drubbing handed to them by the Indianapolis Colts. Coming just two weeks after a shocking 9-6 loss to the lowly Jags, it marked the second time in three games the Bills were held under 20 points.

Entering play Sunday, Buffalo was the NFL’s #3 rush defense, allowing just over 83 yards per game and only five touchdowns all season long. Indy’s Jonathan Taylor shredded the Bills for five TD of his own, including four on the ground.

Bills QB Josh Allen is also harpooning his chances of earning the NFL MVP. In Sunday’s loss, he was picked off twice and fumbled once. Buffalo can’t run the ball a lick. If Allen isn’t firing on all cylinders, they’re doomed as a team.

Bills vs Saints Line Analysis

The line has barely been posted and already there’s been significant movement. Buffalo quickly shortened from 4.5 to 3.5-point favorites. Some sportsbooks already have it down to Bills -2.5.

Expect there to be plenty of action on the Saints this week. New Orleans is Buffalo’s kryptonite.

The Saints are 5-0 straight up in their last five games against the Bills. In those five losses, Buffalo has scored a total of 47 points, or an average of 9.4 points per game.

The Bills have never put more than 17 points on the board in any of the five losses. The Saints are averaging 30.4 ppg over that five-game span.

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