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Opening NFL Week 3 Odds, Lines, Spreads & Early Predictions

John Perrotto

by John Perrotto in NFL Football

Sep 18, 2022 · 5:10 PM PDT

Sep 18, 2022; Baltimore, Maryland, USA; Miami Dolphins wide receiver Jaylen Waddle (17) reacts after his game-winning touchdown catch in the fourth quarter against the Baltimore Ravens at M&T Bank Stadium. Mandatory Credit: Mitch Stringer-USA TODAY Sports
  • The Vikings are the biggest opening favorites in NFL Week 3 at 7.5 points over the Lions
  • The smallest favorites are the Titans over the Raiders by one point
  • A look at all NFL Week 3 opening odds can be found below

Week 3 on the NFL season starts off with a turnpike rivalry as the Cleveland Browns host the Pittsburgh Steelers on Thursday Night Football.

The Browns have opened as three-point favorites at FirstEnergy Stadium. Both teams are 1-1 after losing at home Sunday, Cleveland to the New York Jets 31-30 and the Steelers to the New England Patriots 17-14.

Sunday Night Football has the San Francisco 49ers (1-1) visiting the Denver Broncos (1-1), who are 1.5-point choices. The 1-1 Dallas Cowboys are three-point road underdogs against the New York Giants (2-0) on Monday Night Football. That line and the rest of the up-to-the-minute Week 3 odds can be found on the NFL odds page.

NFL Week 3 Opening Odds

Team Moneyline Spread Over/Under
Pittsburgh Steelers +134 +3 (-110) Over 40.5 (-110)
Cleveland Browns -158 -3 (-110) Under 40.5 (-110)
Team Moneyline Spread Over/Under
Baltimore Ravens -180 -3 (-118) Over 43.5 (-110)
New England Patriots +152 +3 (-104) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Buffalo Bills -235 -4.5 (-115) Over 51.5 (-110)
Miami Dolphins +194 +4.5 (-105) Under 51.5 (-110)
Team Moneyline Spread Over/Under
Cincinnati Bengals -205 -5.5 (-105) Over 43.5 (-110)
New York Jets +172 +5.5 (-115) Under 43.5 (-110)
Team Moneyline Spread Over/Under
New Orleans Saints -138 -2.5 (-110) Over 43 (-110)
Carolina Panthers +118 +2.5 (-110) Under 43 (-110)
Team Moneyline Spread Over/Under
Detroit Lions +295 +7.5 (-115) Over 52 (-110)
Minnesota Vikings -360 -7.5 (-105) Under 52 (-110)
Team Moneyline Spread Over/Under
Kansas City Chiefs -245 -5.5 (-115) Over 49.5 (-110)
Indianapolis Colts +200 +5.5 (-105) Under 49.5 (-110)
Team Moneyline Spread Over/Under
Las Vegas Raiders -108 +1 (-112) Over 45.5 (-110)
Tennessee Titans -108 -1 (-108) Under 45.5 (-110)
Team Moneyline Spread Over/Under
Philadelphia Eagles -198 -3.5 (-110) Over 50.5 (-110)
Washington Commanders -166 +3.5 (-110) Under 50.5 (-110)
Team Moneyline Spread Over/Under
Houston Texans +132 +3 (-115) Over 38 (-110)
Chicago Bears -156 -3 (-105) Under 38 (-110)
Team Moneyline Spread Over/Under
Jacksonville Jaguars +275 +7 (-110) Over 47.5 (-110)
Los Angeles Chargers -335 -7 (-110) Under 47.5 (-110)
Team Moneyline Spread Over/Under
Green Bay Packers +142 +3 (-106) Over 45.5 (-110)
Tampa Bay Buccaneers -168 -3 (-114) Under 45.5 (-110)
Team Moneyline Spread Over/Under
Atlanta Falcons +108 +2.5 (-115) Over 42.5 (-110)
Seattle Seahawks -126 -2.5 (-105) Under 42.5 (-110)
Team Moneyline Spread Over/Under
Los Angeles Rams -210 -4.5 (-115) Over 51 (-110)
Arizona Cardinals +176 +4.5 (-105) Under 51 (-110)
Team Moneyline Spread Over/Under
San Francisco 49ers +116 +1.5 (-110) Over 44 (-110)
Denver Broncos -136 -1.5 (-110) Under 44 (-110)
Team Moneyline Spread Over/Under
Dallas Cowboys +140 +3 (-110) Over 39.5 (-110)
New York Giants -166 -3 (-110) Under 39.5 (-110)

Odds as of September 18th at FanDuel Sportsbook.

The biggest point spread on the board is Minnesota -7.5 against the visiting Detroit Lions. When it comes to game totals, Lions vs Vikings has opened at a high of 52 while the Texans vs Bears is the lowest at 38.0.

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Vikings Biggest Favorite

The Minnesota Vikings (1-0) are the largest picks on the boards at 7.5 points over the Detroit Lions (1-1) at home next Sunday.

The Lions (1-1) got their first win of the season Sunday when they beat the Washington Commanders 36-27 in Detroit.

Jared Goff threw of his four touchdown passes for Amon-Ra St. Brown to lead the Lions. Goff completed 20 of 34 passes for 256 yards.

Aidan Hutchison, the second overall pick in this year’s draft, had three sacks for the Lions, who built a 22-0 halftime lead. Will Harris had a key interception in the second half to thwart the Commanders’ rally.

The Vikings (1-0) visit the Philadelphia Eagles on Monday night. Minnesota opened its season with a 23-7 victory over the Green Bay Packers in Week 1.

Titans vs Raiders Nearly Even

The Tennessee Titans (0-1) are the smallest favorites in Week 3 at one point over the visiting Las Vegas Raiders (0-2) on Sunday.

The Raiders remained winless after losing to the Arizona Cardinals 29-23 in overtime Sunday at home. Byron Murphy Jr. gave the Cardinals the win when he returned Hunter Renfrow’s fumble 59 yards for a touchdown with 3:51 left in OT.

In the first half, the Raiders took a 20-0 lead but couldn’t hold it. Quarterback Derek Carr passed for 252 yards but just 42 after halftime.

The Titans play Monday night against the Bills in Buffalo.

Highest and Lowest Week 3 NFL Game Totals

The Lions vs Vikings matchup has the highest opening total at 52 points. The Lions have scored 71 points in their first two games this season and given up 65.

The 38-point over/under for Texans vs Bears is the lowest total. Houston has managed just 29 points in two games but surrendered just 36 points.

Early NFL Week 3 Predictions

Jaguars vs Chargers

The Los Angeles Chargers are seven-point choices over the visiting Jacksonville Jaguars on Sunday. That spread seems low.

The Jaguars (1-1) are better with Doug Pederson as coach, few would dispute that notion. However, the Chargers (1-1) are still one of the most talented teams in the league despite their loss to the Chiefs at Kansas City on Thursday night and the questionable status of quarterback Justin Herbert.

Pick: Chargers -7 (-110)

Bills vs Dolphins

The defending AFC East champion Bills visit the Dolphins, the team that might be best situated to dethrone Buffalo, on Sunday in Miami. The Bills are 4.5-point favorites.

The Dolphins (2-0) are playing loose and relaxed under new coach Mike McDonald. However, the Bills (1-0) are still the kings of the hill in the division.

Pick: Bills -4.5 (-115)

Packers vs Buccaneers

Two of the all-time great quarterbacks square off in Tampa on Sunday. Tom Brady and the Buccaneers (2-0) are favored by three points over Aaron Rodgers and the Packers (0-1)

The Buccaneers’ offensive has been spotty so far, but the defense has allowed just 13 points in two games. Perhaps that’s not a surprise after defensive coordinator Todd Bowles was elevated to head coach in the offseason. Look for the D to be the difference here.

Pick: Buccaneers -3 (-114)

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