Week 12 NFL Picks Against the Spread – Early Lines to Target

By Robert Duff in NFL Football
Published:

- There are some big lines in the NFL Week 12 against the spread picks, with five games offering favorites of more than a TD and three in double digits
- The Tennessee Titans keep rolling and are 8-0 ATS in their past eight games. And bettors can get points on the Titans in Week 12
- Which NFL teams are looking to be the best bets in the early Week 12 NFL picks against the spread? Read on to find out where the smart money is going
Hard to believe, but Thanksgiving is upon us, and so are the Week 12 NFL picks against the spread.
There are three Thursday games, including a unique scenario that will see the Buffalo Bills playing at Detroit’s Ford Field for the second time in five days. This time, the Bills are even playing the Lions.
The NFL odds are living large in the Week 12 spreads. Bettors can choose from among five favorites who are giving more than a touchdown in the point spread. Three games are featuring double-digit favorites.
Should you be backing or fading any of these teams as best bets in the NFL Week 12 ATS picks? Let’s take a look at that.
Week 12 NFL Picks Against the Spread
Matchup | Spread | Pick | Units Risked |
---|---|---|---|
Buffalo Bills vs Detroit Lions | BUF-10 | BUF | 1 |
Baltimore Ravens vs Jacksonville Jaguars | BAL-4 | BAL | 1 |
Cincinnati Bengals vs Tennessee Titans | CIN-1.5 | TEN | 1 |
Odds as of November 22 at Caesars Sportsbook. Get this Caesars Sportsbook bonus code to bet on the NFL.
Our top NFL ATS picks this week in the table above will feature plays on the Bills, Ravens and Titans.
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NFL ATS Pick 1: Bills Win Again In Detroit
The Bills, who beat Cleveland last week at Ford Field, remain the chalk in the Super Bowl odds. Should they win this game, they’ll have as many wins at Ford Field this season as the Lions (two).
The best hosts for an unexpected home game.
To thank Detroit, we’re donating $20,000 to the @Lions foundation and sent @TimHortonsUS breakfast their way.
Follow our lead and donate to the Lions foundation: https://t.co/PbvAiRwHdO pic.twitter.com/ANO6qjZ2iF
— Buffalo Bills (@BuffaloBills) November 22, 2022
One of the great myths is that there’s a tradition of Detroit success on Thanksgiving. In reality, the Lions are 0-14 straight up and 3-11 against the spread in their last 14 games as a home underdog on Turkey Day.
Pick: Buffalo Bills -10 (-110), 1 unit
NFL ATS Pick 2: Ravens Rebound Against Jaguars
While the Ravens are 5-1 SU in their last six games, they’ve not been as impressive from a betting standpoint. Baltimore is just 2-4-1 ATS over the past seven games.
The Ravens are 4-1 ATS on the road this season. Jacksonville is 1-6 ATS in the past seven games and 0-4 ATS in the past four home games.
Pick: Baltimore Ravens -4 (-110), 1 unit
NFL ATS Pick 3: Titans Cover Yet Again
Something must give in this game. The Titans are 8-0 ATS in their last eight games. They’re also 24-14 ATS as an underdog under head coach Mike Vrabel.
Bengals Week ⚔️
📺: 11/27 on @NFLonCBS pic.twitter.com/4StMd5nbry
— Tennessee Titans (@Titans) November 22, 2022
Cincinnati is 7-1 ATS over the past eight games. And the Bengals are 5-0 ATS in their last five meetings with Tennessee.
Pick: Tennessee Titans +1.5 (-110), 1 unit
- ATS season record 21-11-1
Week 12 NFL Picks Against the Spread Quick Picks
- Cowboys (-7.5) vs Giants: The Giants have so many players on the injured list, they might be arriving in Dallas via ambulance.
- Patriots (+3) vs Vikings: Minnesota QB Kirk Cousins is 2-10 SU and ATS in prime time games.
- Broncos (-2.5) vs Panthers: The Panthers are 4-1 ATS in their past five games. But Denver is 6-1 SU in the last seven against Carolina.
- Commanders (-3) vs Falcons: Washington is 5-0-1 ATS over the past six games.
- Buccaneers (-3) vs Browns: Tampa Bay is looking to cover in consecutive games for the first time since Weeks 1-2.
- Texans (+11.5) vs Dolphins: Houston is 6-2 ATS in its last eight games as a double-digit underdog.
- Jets (-3.5) vs Bears: Jets have a great pass rush, while Chicago is among the worst at protecting the QB.
- Seahawks (-3.5) vs Raiders: If you’re not on board the Geno Smith train by now, well then you just haven’t been paying attention.
- Chargers (-3) vs Cardinals: The Chargers are 5-0 ATS in their last five visits to Arizona and 5-0 ATS in their last five road games.
- Chiefs (-14) vs Rams: The defending Super Bowl champion Rams are down to QB3 on the depth chart.
- 49ers (-8.5) vs Saints: The 49ers are 7-1 SU and 6-2 ATS in their last eight home games.
- Eagles (-8.5) vs Packers: Green Bay is 1-7 SU and 2-6 ATS over the past eight games.
- Colts (-3) vs Steelers: With a defeat, Pittsburgh head coach Mike Tomlin will suffer his first losing season.

Sports Writer
An industry veteran, Bob literally taught the course on the history of sports at Elder College. He has worked as a Sports Columnist for Postmedia, appeared as a guest on several radio stations, was the Vice President of the Society For International Hockey Research in Ontario, and written 25 books.