Alexander Zverev vs Lloyd Harris Odds & Prediction – US Open Men’s Singles Quarterfinals

By Stephanie Myles in Tennis
Published:

- Alexander Zverev is a strong favorite in his US Open quarterfinal match against unseeded Lloyd Harris
- The match will take place Wednesday, September 8, with the winner to play Daniil Medvedev or Botic Van de Zandschulp
- Read on as we break down the matchup, and pick a winner
To meet an unseeded player in the quarterfinals of a major is a gift for anyone aspiring to a Grand Slam title.
But in 24-year-old Lloyd Harris, Alexander Zverev finds himself with a challenge from a player who hits hard and serves very hard.
The winner of Wednesday’s match will play in the US Open semifinals on Friday. And Zverev is heavily favored.
Alexander Zverev vs Lloyd Harris Odds
Player | Spread | Moneyline | Total |
---|---|---|---|
[4] Alexander Zverev (GER) | -6.5 (-110) | -750 | O 34.5 (-120) |
Lloyd Harris (RSA) | +6.5 (-115) | +475 | U 34.5 (-105) |
Odds as of Sept. 7 at DraftKings.
Zverev Impressive Through Four Rounds
The only set Alexander Zverev has lost through the first four rounds was the first set of his third-round match against American wild card Jack Sock.
But the way Sock played that set – with 17 winners and just two unforced errors – he would have won it against anyone.

Beyond that, Zverev has looked imperious.
No. 13 seed Jannik Sinner had been expected to give him a serious tussle. But while the sets were close – 6-4, 6-4, 7-6 (4) – he still got through in two hours, 25 minutes without wasting a lot of excess energy.
Alexander Zverev vs Lloyd Harris Head-to-Head
25 (April 20, 1997) | Age | 24 (Feb. 24, 1997) |
Hamburg, Germany | Birthplace | Cape Town, South Africa |
6-6 | Height | 6-4 |
17 | Career ATP Singles Titles | 0 |
No. 3 (Nov. 6, 2017) | Career High Ranking | No. 46 (Aug. 16, 2021) |
No. 4 | Current Ranking | No. 46 |
$26,122,250 | Career Prize Money | $2,012,145 |
42-11 | 2021 Won/Loss record | 24-17 |
2 | Career Head-to-Head | 0 |
Unseeded Harris Mows Down Seeds
It was somewhat surprising when Harris eliminated No. 7 seed Denis Shapovalov 6-4, 6-4, 6-4 in the third round.
Mostly because Shapovalov has had good success at the US Open. Certainly, it wasn’t on current form, because Harris was on a better track and, at No. 46, sits at a career-high ranking.
Nine double faults from Shapovalov and pressure on the second serve from Harris, in combination, were deadly, as were the 40 unforced errors from Shapovalov. Harris broke him five times.

But Harris was a full participant in his next upset.
Reilly Opelka, the seven-foot American giant with the huge serve, had 24 aces and just two double faults in their fourth-round match.
Harris had 36, won 92 percent of his first serves, and served at a 76 percent first-serve clip. That’s basically unbeatable tennis if you can hold your own on return.
And he did. The South African created 17 break opportunities on Opelka’s serve and converted six of them.
Alexander Zverev vs Lloyd Harris Match History
Year | Tournament | Surface | Score | Winner |
---|---|---|---|---|
2021 | Masters Cincinnati (R32) | Outdoor Hard | 4-6, 7-6 (6), 7-6 (4) | Zverev |
2020 | Cologne (QF) | Indoor Hard | 6-4, 3-6, 6-0 | Zverev |
A Battle of the Big Serves
Harris will have to try to serve as well as he did against Opelka. And he also will have to try to return Zverev’s huge delivery as well he did against Opelka.
To have that kind of day twice. in the same tournament is no small feat for a player who has only recently squeezed into the top 50.
Zverev won’t come to the net as much as Opelka did. The points will be a lot longer.

Zverev’s Winning Head-to-Head Will Help
The two played just a few weeks ago in Cincinnati, under similar conditions.
And Zverev barely squeaked through in tiebreak sets in the second and third sets, after losing the first. That will give Harris a lot of hope that he can go a few points better.
But best-of-five is a different dynamic, and Zverev has a lot more experience at that.
His name is Lloyd.
🇿🇦 Lloyd Harris continues his dream run into the #USOpen quarterfinals! pic.twitter.com/GoQbwemvmZ
— US Open Tennis (@usopen) September 6, 2021
The German seems on a legitimate quest for his first Grand Slam title after taking gold home from the Olympics in Tokyo.
But it doesn’t seem possible that the quest would be ended by Lloyd Harris. Maybe by Novak Djokovic or, failing that, by Daniil Medvedev.
The South African will have to raise his level even beyond what it was against Opelka. Which was very, very high.
There will be tiebreaks; that seems inevitable. A tiebreak in the first set, as they’re feeling each other out, is worth a play at +310.
Best Bet: Zverev to Win in Four Sets (+230)

Sports Writer
Stephanie gets the straight dope from the tennis insiders. On court, she has represented her country internationally. A BA in journalism led to years on the MLB beat and a decade covering tennis globally. She's written for Postmedia, the Guardian, the New York Times and also publishes OpenCourt.ca.