Upcoming Match-ups

Cubs vs Cardinals Odds, Picks & Predictions (June 25)

Robert Duff

by Robert Duff in MLB Baseball

Jun 25, 2022 · 4:51 AM PDT

Cubs vs Cardinals Odds
Jun 24, 2022; St. Louis, Missouri, USA; Chicago Cubs right fielder Jason Heyward (22) leaps and catches a fly ball against the St. Louis Cardinals during the second inning at Busch Stadium. Mandatory Credit: Jeff Curry-USA TODAY Sports
  • The Cardinals are -185 home favorites over the Cubs in an afternoon game on Saturday, June 25
  • Chicago owns a 6-5 edge over St Louis in the last 11 games played at Busch Stadium
  • All of the Cubs vs Cardinals odds, picks, predictions and best bets are analyzed in the following story

The Chicago Cubs (27-44, 14-19 away) generally don’t do well on the road but they at least enjoy their journeys to Busch Stadium to play the St Louis Cardinals (40-33, 21-14 home).

Chicago is 6-5 straight up in the last 11 road games played against St Louis.

Nonetheless, it’s the home team that the oddsmakers are backing in Saturday’s game. St Louis is set as a -185 favorite. Chicago is 11-15 straight up as an away underdog this season.

First pitch at Busch Stadium is set for 2:15pm ET on Saturday, June 25. Mostly sunny skies are in the forecast, with 5 mph wind and a temperature of 97 degrees.

Cubs vs Cardinals Odds

Team Moneyline Runline Total
Chicago Cubs +165 +1.5 (-120) O  (-105)
St Louis Cardinals -185 -1.5 (+100) U 8 (-115)

Odds as of June 25th at Caesars Sportsbook. See available Caesars Sportsbook promo codes



Available in AZ, CO, CT, LA, IA, IN, IL, MI, NJ, NY, PA, TN, VA, WV, WY

Get a Risk-Free Bet Up to $1,500




At odds of -185, the Cardinals are offering an implied probability of victory of 64.91% in the MLB betting line. A successful $10 wager on St Louis would deliver a payout of $15.40.

The MLB betting trends show that in the NL Division odds, a favorite’s betting line of +260 is available on the Cardinals to win the NL Central. Chicago is +6000 to win the division. The MLB pennant odds show the Cardinals at +1600 to win the NL flag. St Louis is at +3500 to win it all in the World Series odds.

Chicago vs St Louis Probable Pitchers

While the sample size is extremely small, the results certainly are encouraging for Cubs right-hander Adrian Sampson. Working two games out of the bullpen covering 5.2 innings, he’s yet to allow an earned run to be scored.

Sampson will be making his first start of the season and first since Oct 2, 2021, at St Louis. The Cubs won 5-4 that day but Sampson, who pitched four innings, didn’t figure in the decision. His last two MLB starts were both against the Cardinals. He faced them on Sept 25, 2021, and again didn’t factor in the decision.

Overall he’s pitched against St Louis three times and is 1-0 with a 2.35 ERA. At Busch Stadium Sampson is 0-0 with a 2.25 ERA. He’s 3-3 with a 3.97 ERA in 17-day game appearances.

Sampson vs Mikolas

Adrian Sampson
Miles Mikolas
0-0 Record 5-5
0.00 ERA 2.64
2.32 xERA 3.40
0.53 WHIP 0.97
2.71 SO/W Ratio 3.93

In two of his last three starts, veteran right-hander Miles Mikolas has worked into the ninth inning. That’s including a complete-game performance on June 9 at Tampa Bay. He had two outs and a two-strike count when Mikolas lost a no-hit bid against Pittsburgh in his previous Busch Stadium start.

He’s struck out 18 against three walks issued while showing a 1.57 ERA over those three games. However, Mikolas is just 1-2 over that span and he’s 2-4 through his last six decisions. He’s 2-2 with a 2.74 ERA, 0.87 WHIP and 4.13 strikeout/walks ratio in seven home starts.

Mikolas got the win in a 14-5 verdict over the Cubs on June 3. He’s 4-2 with a 2.08 ERA in 12 career appearances against Chicago. Mikolas is 13-8 with a 3.75 ERA in 39-day game appearances.

Batting Average vs Starting Pitchers

Cardinals Batters Batting Average vs Sampson Cubs Batters Batting Average vs Mikolas
Nolan Arenado .250 David Bote .000
Harrison Bader .714 Willson Contreras .308
Dylan Carson .000 Yan Gomes .400
Brendan Donovan .000 Ian Happ .389
Tommy Edman .000 Jason Heyward .217
Paul Goldschmidt .000 PJ Higgins 1.000
Nolan Gorman .000 Nico Hoerner .200
Ivan Herrera .000 Tommy Pham .000
Andrew Knizner .000 Christopher Morel .333
Lawrs Nootbaar .000 Rafael Ortega .667
Albert Pujols 1.000 Alfonso Rivas .000
Edmundo Sosa .000 Andrelton Simmons .000
Juan Yepez .000 Nelson Velazquez .000
Patrick Wisdom .333

Several Cubs have enjoyed digging into the batter’s box to face Mikolas. Ian Happ is 7-for-18 (.389) with two RBI. Willson Contreras is 4-for-13 (.308) with an RBI. Yan Gomes is 2-for-5 (.400) and has driven in a run. Patrick Wisdom is 1-for-3 (.333) with a homer and three RBI. Christopher Morel is also .333 (1-for-3). Rafael Ortega is 2-for-3 (.667) and PJ Higgins is 1-for-1 (1.000).

Harrison Bader of the Cardinals has absolutely owned Sampson. He’s 5-for-7 (.714) with two solo homers. Albert Pujols has only faced Sampson once but he couldn’t have fared much better. Pujols crushed a solo blast in his only at-bat against the Cubs righty.

Cubs vs Cardinals Prediction

The Cubs are road warriors in St Louis. They’ve won three in a row at Busch Stadium. You know the last time they won four in a row there? It was a five-game win streak in 2010.

Mikolas is pitching well of late and he’s been solid in his career against the Cubs. Take the Cardinals to rebound at home.

Pick: St Louis Cardinals ML (-185)


Author Image