White Sox vs Guardians Odds and Picks (April 21)

• The White Sox are -135 road favorites over the Guardians on Thursday
• Dylan Cease (2-0, 1.69) will start for Chicago against Zach Plesac (0-1, 1.64).
• A look at the White Sox vs Guardians odds can be found below with a pick

The Cleveland Guardians will try to sweep a series shortened to three games because of inclement weather when they host the Chicago White Sox at 1:10 p.m. ET Thursday at Progressive Field.

After being postponed both Monday and Tuesday, the teams played a doubleheader Wednesday, which the Guardians swept 11-1 and 2-1. The Guardians (6-5/2-3 home) are on a three-game winning streak and the White Sox (6-5/2-3 away) have lost three in a row.

White Sox vs Guardians Odds

Odds as of April 20th at BetMGM.

The White Sox are favored at -135 on the moneyline, giving them a 57.45% implied win probability.

Rain is in the forecast for Thursday morning in Cleveland but is supposed to clear out by first pitch. The high temperature is expected to be 64 degrees with south winds at 13-22 mph and gusting to 32 mph.

Chicago’s World Series odds are +1000 while Cleveland’s are +7000.

Probable Pitchers

Dylan Cease (2-0, 1.69) will pitch for the White Sox against Zach Plesac (0-1, 1.64). Both will be going on five days of rest.

Cease vs Plesac

Cease kept his record perfect last Friday when he beat the Tampa Bay Rays at home. He went 5.2 innings and allowed one run, three hits and two walks while striking out eight.

The good start has made Cease the third choice in the AL Cy Young odds at +850.

I’d say Dylan Cease is pretty good at this pitching thing. pic.twitter.com/X1CjHiH7EP

— Mike (@ChiSoxFanMike) April 18, 2022

Cease is 2-2 with a 5.56 ERA in five career starts against Cleveland and 1-2 with a 7.13 ERA in four starts at Progressive Field.

In his season debut, Cease won a start in the day and on the road when he allowed one run in five innings April 9 against the Tigers at Detroit. Last season, he was 7-5 with a 4.69 ERA in 16 night starts and 4-2 with a 3.00 in 12 day games.

The Guardians’ Amed Rosario is 3 for 7 against Cease.

Plesac lost to the San Francisco Giants last Friday at home, giving up two runs and seven hits in 5.1 innings while striking out four and walking one. He is winless in six starts, stretching to last season.

Against the White Sox, Plesac is 2-4 in his career with a 4.56 ERA in nine starts. It was his first start at home this season after compiling a 3-2 record and 4.10 ERA last season in 12 starts at Progressive Field.

Zach Plesac’s fastball sounds real nice. 😍

via pitchersnation/IG pic.twitter.com/XOiI4gTJ54

— MLB (@MLB) April 28, 2020

Plesac has made one start in the daylight this season, working 5.1 scoreless inning against the Royals on April 9 in a no-decision at Kansas City. He was 4-1 with a 4.73 ERA in eight starts during the day last year.

Luis Robert (5 for 10) and Adam Engel (4 for 10) have both hit Plesac well and have two doubles off him. Eloy Jimenez, though is just .133 (2 for 15) against him with two doubles and six strikeouts.

White Sox vs Guardians Betting Preview

Jose Ramirez shined Wednesday in the doubleheader sweep. His second grand slam highlighted a nine-run second inning in the opener, and he hit an RBI double in the Guardians’ one-run win in the second game.

Ramirez leads the major leagues with 20 RBIs a week after signing a franchise-record seven-year, $141-million contract.

It’s a Grand Slam for the 🐐, so that means we’ve got our FIRST tree to plant to help re-establish the tree canopy in Cleveland with @DaveyTree.

Don’t worry there’s a lot more where that came from! #FortheLand pic.twitter.com/Y7sxp61NGk

— CLE Inspires (@CLEInspires) April 20, 2022

Oscar Mercado also doubled in a run in the nightcap. Emmanuel Clase pitched a perfect ninth for the Guardians’ first save of the season.

Jimenez sat out both games of the twinbill for the White Sox with a sore left ankle but might play Thursday.

Third baseman Josh Harrison left in the sixth inning of the second game with a sore left shoulder after making a diving catch and will likely miss Thursday’s game.

Josh Harrison with an early candidate for catch of the year.

He traveled 97 feet for the ball and reached a sprint speed of 24.8. Still don't know how he caught it. pic.twitter.com/2XUL2FK4ZF

— Henry Palattella (@HellaPalattella) April 20, 2022

This is the first series of the season for the American League Central rivals after the White Sox went 10-9 against Cleveland in 2021.

White Sox vs Guardians Last 10 Meetings

Guardians vs White Sox Prediction

It’s hard to beat a team three times in the span of a little more than 24 hours and Cease is off to a great start with 16 strikeouts in 10.1 innings. This is a good matchup for the White Sox.

The Pick: White Sox runline -1.5 (+125)

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