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Week 4 College Football Picks Against the Spread

Blair Johnson

by Blair Johnson in College Football

Updated Sep 21, 2022 · 10:00 AM PDT

Tennessee quarterback Hendon Hooker gets the snap during the NCAA college football game
Tennessee quarterback Hendon Hooker (5) get the snap during the NCAA college football game against Akron on Saturday, September 17, 2022 in Knoxville, Tenn. Utvakron0917
  • Week 4 of College Football features some intriguing games on Saturday, September 24th
  • Florida vs Tennessee and Arkansas vs Texas A&M are among the marquee matchups
  • Read below for the best ATS picks for Week 4 of the college football season

Week 4 of the 2022 College Football season features a pair of highly intriguing SEC matchups on Saturday, September 24th, with the game between No. 20 Florida and No. 11 Tennessee being the headliner.

In addition to the showdown on Rocky Top, No. 10 Arkansas has a chance to make a massive statement when it visits No. 23 Texas A&M. Meantime, a pair of ranked ACC opponents — No. 5 Clemson and No. 21 Wake Forest — clash in Winston-Salem.

Here are CFB betting odds and three ATS picks to consider for Week 4.

Florida vs Tennessee Odds

Team Spread Moneyline Total
Florida Gators +11.5 (-109) +290 O 62.5 (-108)
Tennessee Volunteers -11.5  (-112) -385 U 62.5 (-113)

All odds as of September 20th at Barstool Sportsbook. See the available Barstool Sportsbook promo code


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ATS Pick #1: Florida (+11.5) vs Tennessee

The Volunteers enter Saturday’s tilt with the Gators as the biggest favorite they’ve been in at least 25 years of the rivalry series. A big reason why is because UT has passed the eyeball test so far in 2022. The Vols blew out Ball State and Akron by a combined score of 122-16 and beat defending ACC champion Pittsburgh 34-27 on the road in overtime. Meantime, UF got past then-No. 7 Utah at home in the opener, but lost to Kentucky and nearly slipped up against South Florida. Now, the Gators have their first road game in a series they’ve won 16 of the last 17 games in.

Heupel’s senior quarterback, Hendon Hooker, has been steady as expected through the first three games. But his top target (Cedric Tillman) and top running back (Jabari Small) both went down with injuries early against the Zips in Week 3. Both situations — especially Tillman’s — will need to be closely monitored leading up to kickoff. The dynamic Tillman is currently listed as day-to-day with a high ankle injury and is “questionable” for Saturday.

Meantime following a breakout performance against the Utes in Week 1 (168 yards passing, 106 yards rushing, three touchdowns accounted for), Florida quarterback Anthony Richardson has crashed back down to earth over the last two weeks. He’s tossed just a total of 423 passing yards this season and was brutal against UK (24-of-53 through the air, zero touchdowns and four interceptions). However, his legs could be the difference at Neyland. Gators head coach Billy Napier has confidence in his signal caller.

On defense, UT is giving up just over 14 points per game, down from 29 per contest last season. The Vols are also allowing opponents 24% on third-down conversions, down from 42% in 2021. But it’s all come against the two worst teams in the MAC and a Pitt squad that was without its starting quarterback for most of the second half. Translation: we don’t really know how good this group is yet.

Tillman is an X-factor. If he can go, the home team should cover. But if he can’t — or even if he’s not at 100% (which it seems like he won’t be) — watch out. Florida has been a thorn in Tennessee’s side for years. That could be the case once again in Knoxville.

  • Pick: Florida +11.5 (-109)

Arkansas vs Texas A&M Odds

Team Spread Moneyline Total
Arkansas Razorbacks +2.5 (-112) +105 O 48.5 (-109)
Texas A&M Aggies -2.5  (-109) -129 U 48.5 (-112)

ATS Pick #2: Arkansas vs Texas A&M (-2.5)

Prior to last year’s 20-10 victory in Arlington, the Hogs had lost nine straight times to the Aggies. Saturday’s tilt is back at Jerry World as Jimbo Fisher’s group continues its recovery from a devastating home loss to Appalachian State.

With LSU transfer Max Johnson now at quarterback, A&M is averaging just 21 points per game. On the bright side, the Aggies are only allowing 9 per outing, good for ninth nationally. Meantime, the Razorbacks are putting up 38 points per game — but allowing 28 (and their pass defense is the worst in FBS).

Arkansas is led by quarterback K.J. Jefferson (770 passing yards, six touchdowns, one interception) and running back Raheim “Rocket” Sanders (440 rushing yards). Don’t forget just two weeks ago, A&M was considered a sleeper CFP participant. I think Gig ‘Em gets ’em.

  • Pick: Texas A&M -2.5 (-109)

Clemson vs Wake Forest Odds

Team Spread Moneyline Total
Clemson Tigers -7 (-110) -265 O 55.5 (-110)
Wake Forest Demon Deacons +7  (-110) +200 U 55.5 (-1010)

ATS Pick #3: Clemson (-7) vs Wake Forest

The Tigers didn’t live up to expectations last year, but feel like they’re on their way back in 2022. Quarterback DJ Uiagalelei is coming along and Will Shipley gave the run game a huge spark with a 139-yard, two-touchdown performance against Louisiana Tech last week.

Meantime, Wake’s offensive scheme is predicated on veteran QB Hartman putting the ball in the running back’s belly — then holding it there until he reads the defense and makes a decision on whether to pull it or hand it off. It’s called the mesh and it doesn’t work on the Tigers’ stout defense.

Look for Dabo’s boys to get a quality road win.

  • Pick: Clemson -7 (-110)
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