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NFL Betting Odds for Week 2 – Moneylines, Spreads & Line Movement for All Games

Robert Duff

by Robert Duff in NFL Football

Updated Sep 16, 2022 · 12:33 PM PDT

NFL Week 2 line movement
Sep 11, 2022; Arlington, Texas, USA; Dallas Cowboys quarterback Dak Prescott (4) hits his hand against Tampa Bay Buccaneers linebacker Shaquil Barrett (58) as he throws the ball during the fourth quarter at AT&T Stadium. Mandatory Credit: Kevin Jairaj-USA TODAY Sports
  • In the NFL betting odds for Week 2, the Detroit Lions are favored for the first time in almost two years
  • There are four teams that are double-digit point picks in the NFL Week 2 odds
  • The moneylines, spreads and line movement for all games in the NFL betting odds for Week 2 are assessed in the story below

In the NFL betting odds Week 2 edition of what’s my line movement, here’s what we know for sure.

For the first time since 2020, the Detroit Lions are the chalk in the NFL odds for a regular-season game. Meanwhile, the Tennessee Titans, last season’s top seed in the AFC, are 10-point underdogs. It’s now possible to put a definite point total on the per-game value of quarterback Dak Prescott to the Dallas Cowboys, and that number is nine.

Before getting into the analysis, let’s look at the up-to-date Week 2 NFL betting lines.

NFL Week 2 Betting Lines

Team Moneyline Spread Over/Under
Miami Dolphins +158 +3.5 (-115) Over 44.5 (-110)
Baltimore Ravens -190 -3.5 (-105) Under 44.5 (-110)
Team Moneyline Spread Over/Under
New York Jets +228 +6.5 (-110) Over 39.5 (-110)
Cleveland Browns -285 -6.5 (-110) Under 39.5 (-110)
Team Moneyline Spread Over/Under
Washington Commanders +105 +1 (-110) Over 48.5 (-110)
Detroit Lions -125 -1 (-110) Under 47.5 (-110)
Team Moneyline Spread Over/Under
Indianapolis Colts -195 -3.5 (-110) Over 45 (-110)
Jacksonville Jaguars +162 +3.5 (-110) Under 45 (-110)
Team Moneyline Spread Over/Under
Tampa Bay Buccaneers -145 -2.5 (-110) Over 44.5 (-110)
New Orleans Saints +122 +2.5 (-110) Under 44.5 (-110)
Team Moneyline Spread Over/Under
Carolina Panthers +110 +2 (-110) Over 43.5 (-110)
New York Giants -130 -2 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
New England Patriots -125 -2 (-110) O 40.5 (-110)
Pittsburgh Steelers +105 +2 (-110) U 40.5 (-110)
Team Moneyline Spread Over/Under
Atlanta Falcons +400 +10 (-110) Over 46.5 (-110)
Los Angeles Rams -550 -10 (-110) Under 46.5 (-110)
Team Moneyline Spread Over/Under
Seattle Seahawks +328 +8.5 (-110) Over 41 (-110)
San Francisco 49ers -430 -8.5 (-110) Under 41 (-110)
Team Moneyline Spread Over/Under
Cincinnati Bengals -355 -7 (-110) Over 41.5 (-110)
Dallas Cowboys +278 +7 (-110) Under 41.5 (-110)
Team Moneyline Spread Over/Under
Houston Texans +360 +10 (-110) Over 46 (-110)
Denver Broncos -480 -10 (-110) Under 46 (-110)
Team Moneyline Spread Over/Under
Arizona Cardinals +192 +5.5 (-110) Over 51.5 (-110)
Las Vegas Raiders -235 -4.5 (-110) Over 51.5 (-110)
Team Moneyline Spread Over/Under
Chicago Bears +360 +10 (-110) Over 41.5 (-110)
Green Bay Packers -480 -10 (-110) Under 41.5 (-110)
Team Moneyline Spread Over/Under
Tennessee Titans +360 +10 (-110) Over 48 (-110)
Buffalo Bills -480 -10 (-110) Under 48 (-110)
Team Moneyline Spread Over/Under
Minnesota Vikings +110 +2 (-105) Over 50.5 (-110)
Philadelphia Eagles -130 -2 (-115) Under 50.5 (-110)

Odds as of September 16th at Caesars Sportsbook. Claim the Caesars Sportsbook promo code to bet on the NFL this weekend

Home teams are favored in 11 of 15 NFL games this weekend. The home teams covered in nine of 16 games on the NFL Week 1 schedule.



Week 2 Biggest Line Movement

The line on the Dallas Cowboys vs Cincinnati Bengals game opened at Dallas -2. Then, as the reality set in that Cowboys quarterback Dak Prescott would be requiring thumb surgery and thus be out for several weeks, it wasn’t only the Dallas Super Bowl odds that took a hit.

The Bengals, like Dallas coming off a Week 1 home-field loss, are now the 7-point chalk in this game. Over the previous two seasons when Prescott didn’t play, the Cowboys were 5-7 straight up.

Biggest Total Movement In Week 2

Just as the spread on the Cowboys vs Bengals game was altered by nine points once Prescott’s unjust status became clear, so too has the total been impacted in a similar fashion.

The over/under for this game opened at 50.5 points. It’s since dipped to 41.5 points.

Minus Prescott for much of the season-opening loss to Tampa Bay, the Cowboys managed to put just three points up on the scoreboard. In eight of the 12 games Dallas has played without Prescott since 2020, the Cowboys have gone under the total.

Lions are Shortest Week 1 Favorites

In 18 games under head coach Dan Campbell, the Detroit Lions are 3-14-1 straight up. But that’s only half the story. At the same time, Detroit is 12-6 against the spread with Campbell in charge as we look into the NFL team trends entering Week 2.

One thing the Lions have never been under Campbell’s tutelage is the chalk, Last week, they couldn’t beat the Philadelphia Eagles, losing 38-35. This week, the Lions are facing Philly’s old QB in Washington’s Carson Wentz. And Detroit does so as 1-point home favorites.

That’s come down from the Week 2 opening line of Detroit -1.5, but it’s still giving the Lions favored status. It’s the first time that’s happened in 24 games.

On November 22, 2020, Detroit was a 3-point favorite at Carolina. The underdog Panthers whipped the Lions 20-0 behind QB Teddy Bridgewater. It’s been so long, that was three starting QBs ago for Carolina.

Biggest Week 2 Spreads

Four teams are favored by exactly 10 points in the betting odds for Week 2.

The reigning Super Bowl champion Los Angeles Rams opened as an 11.5-point pick over the Atlanta Falcons. That spread has since shortened to Rams -10.

Oddsmakers are putting a lot of faith in a Denver Broncos team that couldn’t beat the Seattle Seahawks in Week 1. Denver is a 10-point home choice over the Houston Texans. It’s the 10th time in 17 games that Houston’s been a double-digit point underdog.

It shouldn’t be surprising at all to see the Green Bay Packers as the 10-point home chalk facing the Chicago Bears. Packers QB Aaron Rodgers is 21-5 SU and 17-9 ATS against the Bears. Chicago was a 12-point underdog at Green Bay last season and the Packers covered.

On the other hand, seeing the Buffalo Bills getting 10 points at home to the Tennessee Titans is somewhat shocking. Tennessee did earn the #1 seed in the AFC last season, after all. The Titans are 6-3 ATS in their last nine games against Buffalo.

Jets vs Browns Is the Lowest Total of Week 2

The QB matchup in the Cleveland Browns vs New York Jets game was supposed to be Deshaun Watson vs Zach Wilson. Watson is under NFL suspension. Wilson is injured.

Instead, we’re getting Jacoby Brissett against Joe Flacco and at 39.5 points, the lowest total on the NFL Week 2 schedule.

Starting five games last season for Miami, Brissett averaged 20.2 points per game. In Flacco’s last five starts, his teams are averaging 17.8 PPG. Combined, that adds up to 38 points.

Week 2’s Highest Total is Cardinals vs Raiders

The highest total of the betting odds for Week 2 is being assigned to the Arizona Cardinals vs Las Vegas Raiders game. On the surface, this seems to be misplaced hope.

Four of Arizona’s last six games have gone under. Meanwhile, five of the Raiders’ last six games have also gone under.

Certainly, the Cardinals’ defense figures to do its part. In the last three games, Arizona has surrendered 116 points. Kansas City put 44 up on them in Week 1.

In the last five games, Las Vegas has scored over 20 points twice and over 30 points once. The Raiders have allowed more than 20 points three times and in excess of 30 points once.


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