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NFL Week 2 Odds – Opening Betting Lines & Spreads for All Games

John Perrotto

by John Perrotto in NFL Football

Updated Sep 11, 2022 · 8:44 PM PDT

Los Angeles Rams wide receiver Cooper Kupp warming up
Sep 8, 2022; Inglewood, California, USA; Los Angeles Rams wide receiver Cooper Kupp (10) warms up before the game against the Buffalo Bills at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
  • The Rams are the biggest favorites in the NFL Week 2 opening odds by 11.5 points over the Falcons
  • The Lions are the smallest favorites by 1.5 points over the Commanders
  • A look all the NFL Week 2 opening odds can be found below

Week 2 of the NFL season gets underway Thursday night when the Kansas City Chiefs host the Los Angeles Chargers. The Chiefs have opened as 2.5-point favorites in the Week 2 NFL odds.

Sunday Night Football will feature the Chicago Bears, who are 8.5-point underdogs, visiting the Green Bay Packers.

There will be two games on Monday Night Football with the Buffalo Bills hosting the Tennessee Titans and the Minnesota Vikings visiting the Philadelphia Eagles. The Bills are favored by 9.5 points and the Eagles are 2.5-point picks.

The table below lists the opening odds (point spread, moneyline, and game total) for all Week 2 games currently on the board.

NFL Week 2 Opening Odds

Team Moneyline Spread Over/Under
Los Angeles Chargers +140 +2.5 (-108) Over 53.5 (-110)
Kansas Chiefs -166 -2.5 (-132) Under 53.5 (-110)
Team Moneyline Spread Over/Under
Miami Dolphins +162 +4.5 (-118) Over 45.5 (-110)
Baltimore Ravens -194 -4.5 (-104) Under 45.5 (-110)
Team Moneyline Spread Over/Under
New York Jets +220 +5.5 (-102) Over 42.5 (-115)
Cleveland Browns -270 -5.5 (-120) Under 42.5 (-105)
Team Moneyline Spread Over/Under
Washington Commanders -102 +1.5 (-110) Over 47.5 (-105)
Detroit Lions -116 -1.5 (-110) Under 47.5 (-115)
Team Moneyline Spread Over/Under
Indianapolis Colts -220 -4.5 (-110) Over 45.5 (-110)
Jacksonville Jaguars +184 +4.5 (-110) Under 45.5 (-110)
Team Moneyline Spread Over/Under
Tampa Bay Buccaneers -162 -2.5 (-122) Over 47.5 (-110)
New Orleans Saints +136 +2.5 (+100) Under 47.5 (-110)
Team Moneyline Spread Over/Under
Carolina Panthers +104 +2 (-110) Over 42 (-110)
New York Giants -122 -2 (-110) Under 42 (-110)
Team Moneyline Spread Over/Under
New England Patriots OFF OFF OFF
Pittsburgh Steelers OFF OFF OFF
Team Moneyline Spread Over/Under
Atlanta Falcons +460 +11.5 (-110) Over 48.5 (-110)
Los Angeles Rams -620 -11.5 (-110) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Seattle Seahawks +315 +8.5 (-114) Over 42.5 (-110)
San Francisco 49ers -400 -8.5 (-106) Under 42.5 (-110)
Team Moneyline Spread Over/Under
Cincinnati Bengals +112 +2 (-105) Over 50.5 (-110)
Dallas Cowboys -132 -2 (-115) Under 50.5 (-110)
Team Moneyline Spread Over/Under
Houston Texans +410 +10.5 (-114) Over 43.5 (-114)
Denver Broncos -550 -10.5 (-106) Under 43.5 (-106)
Team Moneyline Spread Over/Under
Arizona Cardinals +152 +3.5 (-114) Over 51.5 (-114)
Las Vegas Raiders -180 -3.5 (-106) Over 51.5 (-106)
Team Moneyline Spread Over/Under
Chicago Bears +350 +8.5 (-106) Over 44.5 (-110)
Green Bay Packers -450 -8.5 (-114) Under 44.5 (-110)
Team Moneyline Spread Over/Under
Tennessee Titans +370 +9.5 (-110) Over 50.5 (-110)
Buffalo Bills -480 -9.5 (-110) Under 50.5 (-110)
Team Moneyline Spread Over/Under
Minnesota Vikings +120 +2.5 (-105) Over 48.5 (-110)
Philadelphia Eagles -142 -2.5 (-115) Under 48.5 (-110)

Odds as of September 11th at FanDuel Sportsbook. Claim the FanDuel Sportsbook promo code

The biggest spread of the week is Falcons vs Rams, which sits at 11.5 in favor of LA. The highest total on the board is 53.5 in the Thursday Night Football game between the Chargers and Chiefs.


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Rams Big Favorites Over Falcons

Despite getting their season off to a bad start with a 31-10 loss to the Buffalo Bills at home on Thursday, the Los Angeles Rams are the biggest chalk on the board in Week 2. The defending Super Bowl-champion Rams are 11.5-point favorites over the Atlanta Falcons at home.

The Rams were hampered by mistakes, most notable Matthew Stafford throwing three interceptions while having 240 yards passing. The Rams are 0-1 and under .500 for the first time in Sean McVay’s six-year tenure as coach.

The Falcons blew a 16-point lead in the fourth quarter Sunday and lost to the New Orleans Saints 27-26 in their opener.

The Falcons’ Cordarrelle Patterson rushed for a career-high 120 yards, including a 5-yard score. Marcus Mariota threw for 215 yards and added 72 yards rushing, highlighted by a 2-yard touchdown run.

On the last play of the game, Younghoe Koo attempted a game-winning 63-yard field goal, but it was blocked.

Commanders Slim Picks

The smallest line is the Washington Commanders favored by 1.5 points at home over the Detroit Lions on Sunday.

Carson Wentz threw four touchdown passes in his Commanders’ debut Sunday as they rallied to beat the Jacksonville Jaguars. He finished 27 of 41 for 313 yards.

Wentz was able to overcome throwing interceptions on consecutive plays in the fourth quarter.

The Lions lost to the Philadelphia Eagles 38-35 at home as a late rally fell short. Detroit was down by 17 points in the fourth quarter and cut the deficit to three on Jared Goff’s 22-yard touchdown pass to DJ Chark with 3:51 remaining but got no closer.

D’Andre Swift rushed for 144 yards and a TD for the Lions on 15 carries.

Highest and Lowest Week 2 NFL Game Totals

The highest total is 53.5 points for the Chargers-Chiefs game. Kansas City beat the Arizona Cardinals 44-21 on Sunday and Los Angeles downed the Las Vegas Raiders 24-19.

The smallest over/under is 42 for the Carolina Panthers-New York Giants matchup in East Rutherford. The Panthers dropped a 26-24 decision to the Cleveland Browns on Sunday while the Giants edged the Tennessee Titans 21-20.

Expected Week 2 Line Movement

The Packers are 8.5-point favorites over the Bears, which is a substantial number. However, the Packers are a betting favorite among the public who likely won’t be deterred to back Green Bay despite its 23-7 loss to the Minnesota Vikings on Sunday. Look for the line to rise during the week.


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