Expert NFL Picks Against the Spread for Week 6

• Get our top NFL ATS picks this week for Week 6, October 15-16, 2023
• Can the Dolphins and 49ers covers as big Week 6 favorites? Who comes out on top in the AFC South rivalry between the Colts and Jaguars?
• Read on for our expert NFL picks against the spread for Week 6 below

In Week 6, our expert NFL picks against the spread are spread all over the board with picks on nine different teams. We have picks on some of the biggest Week 6 favorites in the Dolphins and 49ers, conflicting picks on the Colts vs Jaguars, a pick on the Ravens in London and one selection on Monday Night Football’s Cowboys vs Chargers game. Read on for all of our top Week 6 NFL ATS predictions here.

NFL Expert Picks Today

Our Week 6 expert NFL picks against the spread cover nine different teams from eight different games for Sunday and Monday.

Before making your Week 6 picks against the spread, be sure to sign up at one of the best NFL sportsbook apps to claim your new customer bonus for Week 6.

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Ryan Metivier

Dolphins (-13.5)

Look, in past years I stayed far away from double digit favorites in NFL ATS picks. And to start this season I did the same. And it just didn’t work trying to pick off the small underdogs. There is a massive gulf between some of the top teams and some of the worst teams so far this season and this game fits that bill.

Bryce Young and the Carolina Panthers have been abysmal and have both yet to win a game or cover a spread at 0-5 and 0-4-1. Miami on the other hand are 4-1 in both categories.

In two of the past three weeks the Fins have beat up on bad teams at home beating Denver by 50 and the Giants by 15. And that could’ve been much worse. Miami let up and New York’s only touchdown came off a pick six. I’m betting on another blowout here for my Week 6 expert NFL picks against the spread. The Dolphins are tops in PPG and YPG this season at 36.2 and 513.6.

49ers (-9.5)

I had two winners last week backing big favorites so let’s do it again. The line has moved a lot in the 49ers vs Browns odds this week with Deshaun Watson set to miss out and PJ Walker stepping in. Walker hasn’t played this season and only started five games last year with the Panthers where he threw three touchdowns and also three interceptions.

The 49ers are on a 15-0 regular season and 17-1 overall run. Brock Purdy is 10-0 SU and 8-1-1 ATS as a starter in the regular season. And the 49ers have led for a season-high 237 minutes this season. Without Watson and with rookie Dorian Thompson-Robinson two weeks ago, the Browns lost 28-3 to the Ravens. I don’t see Walker having any better success.

Brock Purdy's final line from San Francisco's dominant performance against Dallas on Sunday Night Football:

1️⃣7️⃣ – 2️⃣4️⃣ passing
2️⃣5️⃣2️⃣ yards
4️⃣ touchdowns
0️⃣ interceptions
1️⃣0️⃣-0️⃣ regular season record as a NFL starter#CyclonesInTheNFL pic.twitter.com/FIc746jjJC

— CycloneFanatic.com (@cyclonefanatic) October 9, 2023

Chargers (+2.5)

The Chargers come in fresh off a bye and riding a two-game winning streak beating the Vikings and Raiders. Los Angeles is seventh in scoring, Justin Herbert is sixth in yards per pass and has thrown seven touchdowns to just one interception. Austin Ekeler could also return from injury as he was a full participant in practice Thursday.

Unfortunately the Chargers’ defense is non-existent ranking 24th in PPG allowed and 32nd in passing yards allowed.

But maybe, against Dallas, they won’t get exposed. Dak Prescott is not throwing deep much this year, with the Cowboys favoring the short game and Dak’s 6.6 yards per pass attempt ranks 25th.

Dallas has beaten up on the the Giants, Jets and Patriots, three teams who are a combined 4-11. They gave the Cardinals their only win on the season and just got blown out on SNF to the 49ers 42-10. I’m betting the Dallas secondary minus Trevon Diggs struggles to slow down Herbert and the Chargers pull off a MNF upset in my expert NFL picks against the spread for Week 6.

Bob Duff

Eagles (-6.5)

The New York Jets have more wins in the Super Bowl than they do against the Philadelphia Eagles. Twelve tries, 12 losses, 1-11 ATS. The only time the Jets covered was a 21-20 home-field loss as 8-point underdogs in 1996.

Philly is 17-6 ATS in the last 23 games against AFC opponents. The Eagles are 10-2 SU in their last 12 road games.

Jaguars (-4)

Gardner Minshew opened the 2020 season leading the Jaguars to a 27-20 upset of the Colts. In 12 games since as an NFL starting QB he’s 2-10 SU, but this season the Colts are 3-0 when he completes a pass. Minshew gets the start for Indianapolis on Sunday against his old club. Rookie QB Anthony Richardson (shoulder) is out for the Colts.

The Jaguars are back home following successive wins in England. Jacksonville is 14-2-1 ATS in the last 17 games against Indy.

Ravens (-4)

Tennessee let Zack Moss gain 165 yards on the ground last week. This week, they get the NFL’s #4 run game in Baltimore. The Ravens are averaging 146 yards rushing per game. Baltimore QB1 Lamar Jackson leads all QBs with 265 yards on the ground.

Also, Tennessee is 0-3 SU on the road this season. According to the map, London, England is not in Tennessee.

Zach Reger

Colts (+4)

It’s a Gardner Minshew revenge game in Jacksonville. In multiple appearances this season, the Colts offense has not skipped a beat with Minshew under center. These two teams have also already played each other this season, and while the Jaguars pulled away late and covered, the Colts were right there. They will be motivated to beat their AFC South rival who might come out a little sluggish after a two-week trip across the pond.

"Gardner Minshew is a DAWG and his work ethic is off the charts" ~ @LaneJohnson65

He's been AWESOME for the Colts #PMSLive pic.twitter.com/zyT8BiwPWX

— Pat McAfee (@PatMcAfeeShow) October 13, 2023

Falcons (-2.5)

After last week’s win against the Texans, Desmond Ridder remains undefeated at home in college and the NFL. One week later, Desmond Ridder is at home again against the Commanders. Ridder has had some bad games, but he has also looked capable enough in games. I expect him to play well Sunday against a Commanders defense that has given up 33, 37, 34, and 40 points in their last four games. Atlanta should win this game by more than a field goal.

Seahawks (+3)

The Bengals finally looked like their old selves last week against the Cardinals, but let’s not overreact. Cincinnati will have a more difficult test against a Seattle defense who is fresh off the bye. On the other side of the ball, the Bengals have allowed the fifth-most rushing yards this season. Seattle wants to run the ball and should have success against Cincinnati’s defense. The Seahawks have more than enough talent to keep this game close.