Opening Week 11 College Football Odds, Lines & Early Picks 2025

• The NCAAF Week 11 odds have been posted
• #10 BYU vs #13 Texas Tech, and #3 Texas A&M vs #19 Missouri will both have big CFP implications
• See the Week 11 college football odds for all the power-conference and top-25 games

The majority of the Week 11 college football odds have already been posted at online sportsbooks. Several of the top teams have relatively easy matchups. Just two ranked-on-ranked games are on the NCAAF Week 11 schedule. But this late in the season, every week is bound to shake up the 12-team College Football Playoff picture.

The table below lists the opening Week 11 college football odds for all games involving power-conference teams or top-25 teams. More games/lines will be added throughout the day. Under the table, find my favorite early lines to target in Week 11.

Week 11 College Football Odds & Lines

A line that would have made heads explode in Week 1, #2 Indiana is a 13.5-point road favorite at Penn State. The Nittanies were the preseason #2 team in the nation and are now 0-5 in Big Ten play.

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The national championship odds continue to heavily favor undefeated #1 Ohio State (between +200 and +230). The #2 Indiana Hoosiers are the second-favorite at +500, followed by #4 Alabama (+700).

If the projected CFP bracket has that trio of teams plus #3 Texas A&M receiving byes to the quarterfinal.

Early NCAAF Week 11 Picks

Texas Tech (-9.5) vs BYU

Unlike BYU (8-0 SU), Texas Tech (8-1) has a straight-up loss on its resume, falling 26-22 at Arizona State. Other than than, the Red Raiders have been pristine, with all eight of their wins coming by 23 points for more. BYU has had a couple close calls against inferior teams (24-21 @ Colorado, 33-27 @ Arizona) and this will be the Cougars’ first road game against a ranked team this season. Texas Tech’s superior offensive efficiency and home-field advantage create a significant edge. TTU wins this one going away.

Missouri Moneyline (+190) vs Texas A&M

The #3 Aggies are obviously a very good team, but I am not prepared to put them in the category of great. Three of their wins have been by six points or fewer, including a narrow 45-42 win over two-win Arkansas, a team still looking for its first power-conference victory of the season.

Missouri is the type of team that can hang with anyone, especially on its home field. In their 27-24 home loss to Alabama, they matched the Tide in total yards (325 apiece) and likely win the game if not for a -1 turnover margin. This is a great price for a team as solid as Missouri on its home field.