San Francisco 49ers vs Indianapolis Colts Same-Game Parlay – Get a

• Brock Purdy and the 49ers visit Philip Rivers and the Colts on MNF tonight
• Rivers threw for just 121 yards in his first game back from retirement last week
• See my three-leg, +347 49ers vs Colts same-game parlay for Monday Night Football

A pivotal late-season clash with significant playoff implications unfolds as the San Francisco 49ers travel to Indianapolis to face the Colts on Monday Night Football. This will mark the second game in Philip Rivers’ comeback tour after his Colts lost an 18-16 heartbreaker in Seattle last week, easily covering as two-touchdown road underdogs.

Rivers, however, was thoroughly underwhelming (120 passing yards), and it’s hard to see the 44-year-old being much more prolific against the Niners, despite the change of venue to Lucas Oil Stadium.

An under bet on Rivers concludes my 49ers vs Colts SGP for Monday Night Football, which kicks off at 8:15 pm ET.

49ers vs Colts Same-Game Parlay

The three legs of this 49ers/Colts SGP work out to a +347 parlay at FanDuel Sportsbook, meaning a $100 bet would profit $347 if all three legs hit.

Odds as of 12:38 pm ET at FanDuel Sportsbook. Claim the top NFL betting promos for MNF.

SF 49ers vs IND Colts SGP Pick #1: San Francisco Moneyline (-240)

The 49ers’ mastery of situational football provides the foundation for covering this spread. Their 49.2% third-down conversion rate ranks among the league’s elite, creating sustained drives that control field position and wear down opposing defenses while keeping their own unit fresh and rested.

Despite the Colts averaging more points per game (27.7 to San Francisco’s 24.3), the 49ers’ methodical offensive approach is specifically designed for road success. Their ability to control time of possession (31:10 per game) directly counters Indianapolis’s high-tempo attack by limiting possessions and creating favorable game flow.

Key Situational Trends Supporting San Francisco:

• The 49ers are 8-3 against the spread in their last 11 games as road favorites of 3.5 points or more
• Indianapolis struggles against quality opposition, posting just a 2-6 ATS record in their last eight games against teams with winning records
• San Francisco’s disciplinary advantage (5.2 penalties per game vs. Indianapolis’s 6.1) creates additional field position advantages

While the 49ers’ negative turnover differential (-5) presents concern, their offensive efficiency metrics suggest they can overcome occasional mistakes through sustained drives and clock control.

SF 49ers vs IND Colts SGP Pick #2: Kittle Over 66.5 Receiving Yards (-112)

With defensive coordinators naturally focusing their attention on Christian McCaffrey’s versatility, opportunities will emerge for the 49ers’ other elite offensive weapons. Kittle represents the most reliable target in San Francisco’s passing attack, particularly against a Colts defense that may struggle with his unique combination of size and route-running precision.

The market has already recognized this value, moving Kittle’s line upward from an opening number of 63.5 yards. With Ricky Pearsall listed as “Did Not Participate” due to a knee injury, Kittle’s target share could see additional growth in the game plan.

Purdy’s passing yardage prop sits at 243.5 yards, and Kittle consistently serves as his most dependable weapon for chunk plays over the middle of the field.

SF 49ers vs IND Colts SGP Pick #3: Rivers Under 160.5 Passing Yards

Rivers was severely limited in his ability to throw downfield against the Seahawks. He managed just 120 yards despite completing 18 passes on 27 attempts (a decent 66.7 completion percentage). That’s an average of just 6.7 yards per completion.

The Niners don’t have the defense that the Seahawks do. Seattle rates first in Defensive DVOA compared to San Francisco in 25th. But expecting 41 more yards from Rivers is a big stretch. First, the Colts are likely to lean as heavily as possible on Jonathan Taylor and the ground game.

Second, it’s largely the Niners rush defense that’s let them down this season (27th at PFF) not the coverage unit (20th at PFF).

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