NFL Week 4 Odds – Spread, Total, Moneyline for All 16 Games
By Sascha Paruk in NFL News
Published:
The 2026 NFL season moves quickly into its fourth week of action, and DraftKings has already posted opening lines across the slate. Week 4 brings several heavyweight non-conference battles, classic division rivalries, and pivotal early-season measuring sticks.
The action begins with an AFC North Thursday night clash in Cleveland between the Cleveland Browns (2-1) and Pittsburgh Steelers (2-1) and extends through an action-packed Sunday before wrapping up with Monday Night Football in New Orleans when the Atlanta Falcons (1-2) visit the Saints (1-1).
Below is the complete 16-game Week 4 odds board, including available opening lines and pending matchups.
NFL Week 4 Odds
Odds as of Sep 27 at DraftKings. Claim the best NFL betting promos ahead of Week 4.
Opening Steelers vs Browns Odds
Week 4 action kicks off at Huntington Bank Field on Thursday night, where the Pittsburgh Steelers (2-1) are 2.5-point road favorites (-120) over the Cleveland Browns (2-1, +100) in the opening TNF odds. DraftKings has installed Pittsburgh at -148 on the moneyline (59.7% implied win probability), with Cleveland returning at +124. Both AFC North rivals enter on high notes following Week 3 victories – Pittsburgh edged Cincinnati 30-27 at home, while Cleveland held off Carolina 21-18 to earn its second straight win.
The total is listed at 38.5 points with standard -110 juice on both sides, projecting a classic, hard-nosed defensive battle between division foes.
Opening Patriots vs Bills Odds
An AFC East rivalry heads to Highmark Stadium on Sunday morning, where the Buffalo Bills (3-0) are 7-point home favorites (-105) over the New England Patriots (1-2, -115). DraftKings has installed Buffalo at -340 on the moneyline (77.3% implied win probability), while New England comes back as a +270 road underdog. Buffalo stayed perfect on the year with a 24-16 home victory over the Chargers in Week 3, whereas the Patriots will look to rebound after suffering a 35-6 road loss to Jacksonville.
The total is listed at 48.5 points (O -110 / U -110), anticipating Buffalo’s potent offense setting the tempo.
Opening Rams vs Eagles Odds
Lincoln Financial Field hosts a heavyweight NFC showdown on Sunday, with the Los Angeles Rams (1-1) opening as 2.5-point road favorites (-105) over the Philadelphia Eagles (2-0, -115). DraftKings lists the Rams at -135 on the moneyline (57.4% implied win probability), with the Eagles offering +114 value at home. Philadelphia enters unbeaten after a pair of tight wins over Washington and Tennessee, while the Rams look to carry momentum from their dominant 28-6 Week 2 win over the Giants.
The total sits at 45.5 points (O -110 / U -110), expecting a competitive, mid-scoring clash in South Philly.
Opening Lions vs Panthers Odds
Sunday Night Football heads to Bank of America Stadium, where the Detroit Lions (2-1) are 3-point road favorites (-110) against the Carolina Panthers (1-2, -110). DraftKings has installed Detroit at -155 on the moneyline (60.8% implied win probability), with Carolina listed at +130. The Lions got back in the win column in Week 3 with a 31-24 home victory over the Jets, while the Panthers fell just short in a 21-18 road loss to Cleveland.
The total is set high at 49.5 points with standard -110 juice on both sides, signaling fireworks under the Sunday night lights.
Opening Chiefs vs Raiders Odds
AFC West rivals collide at Allegiant Stadium on Sunday afternoon, where the undefeated Kansas City Chiefs (3-0) open as 5.5-point road favorites (-110) over the Las Vegas Raiders (2-1, -110). DraftKings lists Kansas City at -250 on the moneyline (71.4% implied win probability), while Las Vegas offers +205 value as a home underdog. Kansas City rolled past Miami 24-10 in Week 3 to remain unblemished, whereas the Raiders suffered their first defeat of the season in a tight 16-13 defensive slugfest against New Orleans.
The game total opens at 45.5 points (O -110 / U -110). Through three weeks, the under has been a strong trend for Las Vegas, with all three of their contests staying under 41 total points behind a defense allowing just 13.3 PPG. Meanwhile, Kansas City is averaging 29.3 PPG but also held Miami to 10 points last week, making this total a battle between Las Vegas’ grind-it-out defensive style and Patrick Mahomes’ explosive offense.
Opening Colts vs Commanders Odds
Week 4’s international slate heads across the pond to Tottenham Hotspur Stadium in London, where the Indianapolis Colts (1-2) are 3.5-point favorites (-110) over the Washington Commanders (1-2, -110). DraftKings has installed Indianapolis at -192 on the moneyline (65.8% implied win probability), with Washington priced at +160. Indianapolis captured its first win of the season in Week 3 with a 19-17 victory over Houston, while Washington outlasted Seattle 33-31 in a high-scoring thriller.
The total is set at 46.5 points with -110 juice on both sides. Both squads have leaned heavily toward high-scoring affairs to start 2026; Washington’s games have averaged a robust 55.7 combined points (with all three games seeing at least 46 points and two topping 56), while the Colts were involved in back-to-back 60+ point shootouts against Baltimore (64) and Kansas City (63) before last week’s lower-scoring divisional clash.
Opening Falcons vs Saints Odds
The Week 4 slate concludes on Monday Night Football at the Caesars Superdome, where the New Orleans Saints (1-1) are 2.5-point home favorites (-120) over the NFC South rival Atlanta Falcons (1-2, +100). DraftKings has installed New Orleans at -148 on the moneyline (59.7% implied win probability), with Atlanta returning at +124. The Falcons arrive with momentum after a dominant 35-14 primetime win over Green Bay on Thursday night in Week 3, while the Saints look to protect home turf in their first divisional matchup of the season.
The total is posted at 46.5 points, shaded slightly toward the over at -115 (Under -105). Atlanta’s offense broke out in a big way last week to push their Week 3 game well over the closing total after seeing their first two games average just 35.0 total points. New Orleans has shown high variance across its opening games, ranging from a 61-point shootout against Detroit in Week 1 to a 29-point defensive battle against Las Vegas, setting up an intriguing O/U benchmark for this heated divisional rivalry.
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Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
