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How to Use Prediction Markets for Lions vs Bills: Trade on Thursday Night Football

By Paul Lebowitz in NFL News

Published:


how to use prediction markets for thursday night football
Sep 13, 2026; Houston, Texas, USA; Buffalo Bills quarterback Josh Allen (17) passes the ball during the game against the Houston Texans at Reliant Stadium. Mandatory Credit: Troy Taormina-Imagn Images. IMAGN IMAGES via Reuters Connect.
  • It’s already NFL Week 2, and Thursday Night Football has a marquee matchup with the Detroit Lions visiting the Buffalo Bills
  • The Bills’ brand-new home, Highmark Stadium, will open in Orchard Park, NY; kickoff is scheduled for 8:25 PM ET on Amazon Prime Video
  • Fans can enjoy the action on multiple levels; that now includes using the available prediction markets to make trades and seek profit

For NFL Week 2’s Thursday Night Football matchup of Lions vs Bills in Orchard Park, NY, two top teams and early Super Bowl contenders clash. Before kickoff arrives, now is a great time to read up on how to use prediction markets for Lions-Bills on Thursday Night Football.

The game will be on Amazon Prime Video, and kickoff is scheduled for 8:25 PM ET. These same teams had what was arguably the game of the decade in 2024 when they engaged in a shootout in Detroit, with Buffalo ultimately emerging with a 48-42 win.

Despite both teams having been at the top of the league over the past three seasons, neither has broken through to the Super Bowl. In Week 1, the Lions held off the Saints with an overtime victory after New Orleans tried for a game-winning 2-point conversion and failed. The Bills won a seesaw affair with the Texans in Houston. Buffalo is led by megastar QB and former NFL MVP Josh Allen; Detroit’s transcendent running back Jahmyr Gibbs paces their offense.

This is a test game for both teams. Along with the on-field action, prediction markets give fans the chance to weigh in and try to profit on their knowledge and hunches.

How to Use Prediction Markets for Lions vs Bills

Prediction markets give NFL fans and observers the chance to invest in the Thursday Night Football clash between the Lions and Bills. It took no time at all for the NFL storylines to explode. In the context of other teams’ controversies, particularly the Packers’ Sunday collapse and the Browns being the Browns, the Lions and Bills had a very positive Week 1 with hard-fought victories.

Users can invest in the game winner, points scored, individual performances, and much more. These two teams boast high-powered offenses and questionable defenses. The Bills are working with a new head coach, hoping that after the change from Sean McDermott to former offensive coordinator and Josh Allen ally Joe Brady, they can stop knocking on the championship door and kick it in. The Lions had an underwhelming season in 2025 after again falling short in their Super Bowl dreams. Head coach Dan Campbell is pushing his troops for a rebound.

Currently, the markets suggest that investors are heavily in favor of the Bills, with about 70% leaning in that direction. More than half expect there to be a high-scoring affair. In their meeting two years ago, they combined for 90 points, so if it’s another slugfest, this could be a good market to invest in. There are player props, team props, game props, and game lines.

Trading on the NFL is simple. Find the market to trade on, make a pick, and buy a contract for the selection. That’s it. Making an accurate prediction will yield the full value ($1) for every contract. Contracts for the picks are priced from $0.01-$0.99 based on implied market probability. Even if it sounds a bit confusing, it’s easy to grasp after becoming accustomed to how it works.

Since prediction markets are available for the NFL and every area of life under the sun and even to the stars, there are infinite opportunities. There are offers and promos for Lions vs Bills and more linked below.

Polymarket

POLYMARKET
Deposit $10 & Get a $50 Trade Bonus!

18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading involves high risk and may result in loss of your entire investment. See polymarket.us/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated derivatives exchange and clearing organization.
SIGN UP
CODE: DIME
CODE: DIME
SIGNUP OFFER
DEPOSIT $10
GET $50 BONUS

TRADE NOW

Polymarket has almost become synonymous with prediction markets. It is available in more than 40 states and gives users the chance to make a pick for Lions vs Bills in so many ways that there’s something for everyone. Polymarket is a trusted outlet and lets users claim the Polymarket promo code to deposit $10 and get a $50 bonus.

Kalshi

KALSHI TRADING
Trade $25 at Kalshi & Get a $25 Bonus!
Must be 18+ years or older & residing in the United States. Other Terms & Conditions may apply.
LOCK IN PROMO
CODE: DIME
CODE: DIME
SIGNUP TODAY
TRADE $25
GET $25

GET OFFER

Kalshi is right up there in terms of recognizability. It too is available in more than 40 states. For fans who want to test their NFL knowledge for TNF, they can do it here. Think the Lions and Bills will come out firing and pile on the points? Kalshi has a market for that. Using the Kalshi referral code, new users can receive a $25 bonus once $25 in trades have been completed.

Novig

NOVIG PREDICTION
MARKET

Deposit $10 & Get $25 in Trade Credits!

Restrictions & requirements apply. Not available in all states. 21+. Event contract trading involves risk & is not appropriate for all. Consider if it's appropriate for you in light of financial circumstances. See novig.com/terms for information.
SIGN UP
CODE: DIME
CODE: DIME
SIGNUP OFFER
DEPOSIT $10
GET $25

IN TRADE CREDITS

TRADE NOW

It seems everyone is talking about Novig with the Sydney Sweeney ad campaign accruing global attention, understandably.

As for its technical benefits, it is available in over 40 states. In addition, users can access it in areas where sports betting is not yet allowed. With Novig, the name itself is telling (no vig), meaning a “house” isn’t trying to profit with every pick. This maximizes the odds for users.

With the Novig promo code, new users can deposit $10 and receive $25 in trade credits.

Underdog Predict

UNDERDOG PREDICT
Get a 50% First-Time Deposit Match Up to $1,000 & Play Keep Your Million!

Trading involves risk, including total loss on positions. Trading decisions and their consequences are your sole responsibility. Nothing on underdogexchange.com constitutes a recommendation, solicitation, or offer to buy or sell any financial instrument. UDX is subject to CFTC regulatory oversight. Promotion issued by affiliate.
PLAY NOW
CODE: SBD
CODE: SBD
PREDICTION MARKETS
50% MATCH
UP TO $1,000

TRADE NOW

Underdog Predict is available for users in more than 30 states across the nation as well as Washington D.C.

A major positive with this platform is that it is a Commodity Futures Trading Commission (CFTC) registered platform and is regulated by the Securities and Exchange Commission (SEC). So users who want to make a pick for Lions-Bills in any way can do so here.

The Underdog Predict promo code offers a 50% deposit match up to $1,000 and Keep Your Million for new users on the Underdog Sports app.

OG

OG TRADING
MARKET
Trade $25 & Get a $25 Welcome Offer at OG Trading Market!

Must be 18+ years or older & residing in the United States. Other Terms & Conditions may apply.
LOCK IN PROMO
CODE: DIME
CODE: DIME
SIGNUP TODAY
TRADE $25
GET $25

SIGN UP TODAY

OG is also regulated by the CFTC. Its platform lets users trade on a peer-to-peer basis. Users who are happy with how their prediction is going during the event but have concerns that the score or a player’s performance will not hold can sell or close the contract before the end of the game and walk away. So if the Lions build up a lead and the user has picked them to win, they can cash out before Allen has the chance to carry the Bills to a comeback victory.

Using the OG promo code gives users the chance to trade $10 and get a $10 bonus for using the platform.

ProphetX

PROPHETX


Trade $50 & Get a $75 Bonus at Prophet Exchange!

SIGN UP NOW
CODE: SBDIME
CODE: SBDIME
SIGN UP TODAY
TRADE $50
GET $75 BONUS

TRADE NOW

ProphetX has been approved by the CFTC and is available across the United States. It is the first federally regulated sports-native prediction market. With ProphetX, the market sets the price. The house does not. With that, it is a true peer-to-peer system.

Using the ProphetX promo code, new users can trade $50 and receive a $75 bonus.

Onyx Odds

ONYX ODDS


Spend $10 & Get $111 in Bonus Picks at Onyx Odds!

TRADE NOW
CODE: DIME
CODE: DIME
SIGNUP OFFER
SPEND $10
GET $111

IN BONUS PICKS

SIGN UP

Users in more than 30 states can use Onyx Odds. It has a unique sweepstakes system with virtual currencies. Users can test themselves with the free-to-play options and see how they do before they invest their money.

With the Onyx Odds promo code, users who spend $10 can get $111 in Bonus Picks.

FanDuel Predicts

  • FANDUEL PREDICTS (APPLE USERS)

    GET A $100 BONUS WHEN YOU TRADE $1 FOR 5 DAYS!

  • FANDUEL PREDICTS (ANDROID USERS)

    GET A $100 BONUS WHEN YOU TRADE $1 FOR 5 DAYS!

  • FANDUEL PREDICTS T&Cs: Offered by FanDuel Prediction Markets LLC, a registered futures commission merchant. 18+ and present in select states. First real money trade only. First-time deposit required. Min. $1 trade required for 5 consecutive days for max bonus. Bonus issued as non-withdrawable Predicts Bonus that expires 24 hours after receipt. Restrictions apply. Trading derivatives involves significant risk and may not be suitable for all investors. Manage your activity with our Consumer Protection tools. See terms, including eligible states, at http://fanduel.com/predicts/new-customer-offer

FanDuel is one of the most recognizable names in fan participation in sports. It now has a prediction market that is available in all 50 states. The name itself inspires trust. With FanDuel, user location is important, as there are limits to trading based on where the user is. Still, there are massive benefits.

The FanDuel promo code provides new users with $100 in bonuses after trading $1 daily for 5 days.

Crypto.com

CRYPTO.COM TRADING
Sign Up Today for $50 Bonus in CRO at Crypto.com!

Must be 18+ years or older & residing in the United States. Other Terms & Conditions may apply.
LOCK IN PROMO
SIGNUP TODAY
UP TO $50 BONUS IN CRO!

SIGN UP TODAY

Crypto.com is regulated by the CFTC. Its benefits include rapid payouts, an easy-to-understand structure, and letting users sell their contracts prior to the event’s conclusion. Users can make deposits with crypto and fiat currency. The Crypto.com promo code offers a bonus of up to $50 in CRO for new users.

The NFL has come out swinging, and this TNF matchup offers a star-studded battle between the Lions and Bills in Buffalo’s spankin’ new stadium. Prediction markets can add to the excitement starting now.

Paul Lebowitz

Paul Lebowitz is a novelist, columnist, social commentator, and the author of eight published books on baseball โ€“ one novel and seven baseball guide/previews. He covers sports, politics, and pop culture. Paul graduated from Hunter College with a degree in English. He lives in New York City.

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